{"id":"https://openalex.org/W2185805973","doi":null,"title":"Effects of central and peripheral administration of leptin on pain threshold in rats and mice.","display_name":"Effects of central and peripheral administration of leptin on pain threshold in rats and mice.","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2185805973","mag":"2185805973","pmid":"https://pubmed.ncbi.nlm.nih.gov/14523356"},"language":"en","primary_location":{"id":"pmid:14523356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14523356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11508/47930","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070614308","display_name":"Selim Kutlu","orcid":"https://orcid.org/0000-0001-9257-4797","observed_orcids":["https://orcid.org/0000-0001-9257-4797"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Selim Kutlu","raw_affiliation_strings":["Firat University, The Institute of Health Science, Department of Neuroendocrinology, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firat University, The Institute of Health Science, Department of Neuroendocrinology, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031755463","display_name":"Sinan Canpolat","orcid":"https://orcid.org/0000-0002-1951-3987","observed_orcids":["https://orcid.org/0000-0002-1951-3987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sinan Canpolat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031085901","display_name":"S\u00fcleyman Sandal","orcid":"https://orcid.org/0000-0002-8916-3329","observed_orcids":["https://orcid.org/0000-0002-8916-3329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suleyman Sandal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054598270","display_name":"Mete \u00d6zcan","orcid":"https://orcid.org/0000-0002-5551-4880","observed_orcids":["https://orcid.org/0000-0002-5551-4880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mete Ozcan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047740699","display_name":"Mustafa Sars\u0131lmaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustafa Sarsilmaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074125485","display_name":"Haluk Kele\u015ftimur","orcid":"https://orcid.org/0000-0001-9971-5716","observed_orcids":["https://orcid.org/0000-0001-9971-5716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haluk Kelestimur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3794,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.59148936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"3-4","first_page":"193","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/pain-threshold","display_name":"pain threshold","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7239999771118164},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.6830000281333923},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9210000038146973},{"id":"https://openalex.org/keywords/intraperitoneal-injection","display_name":"intraperitoneal injection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/circadian-variation","display_name":"circadian variation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/peripheral-administration","display_name":"peripheral administration","score":0.5320000052452087},{"id":"https://openalex.org/keywords/central-administration","display_name":"centralized management","score":0.6470000147819519},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6700000166893005},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9544922113418579},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6814274787902832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6621906161308289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5996353030204773},{"id":"https://openalex.org/C3673659","wikidata":"https://www.wikidata.org/wiki/Q1098125","display_name":"Threshold of pain","level":2,"score":0.4780500531196594},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.47012150287628174},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4511803388595581},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.19594469666481018}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:14523356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14523356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Comparative Study"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/47930","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/47930","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2185805973","doi":null,"is_oa":false,"landing_page_url":"https://www.nel.edu/pdf_w/24_34/NEL243403A07_Kutlu_wr.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2398785842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14523356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:openaccess.firat.edu.tr:11508/47930","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/47930","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1604789859","https://openalex.org/W1971558350","https://openalex.org/W1977129903","https://openalex.org/W1980722910","https://openalex.org/W1982319998","https://openalex.org/W2013905794","https://openalex.org/W2014769342","https://openalex.org/W2018901856","https://openalex.org/W2036396565","https://openalex.org/W2045522208","https://openalex.org/W2052679569","https://openalex.org/W2068633406","https://openalex.org/W2081342072","https://openalex.org/W2136634210","https://openalex.org/W2137346546","https://openalex.org/W2402841195","https://openalex.org/W2410795380","https://openalex.org/W2413951839","https://openalex.org/W2414691466","https://openalex.org/W2467209030"],"related_works":["https://openalex.org/W2398785842","https://openalex.org/W1989347345","https://openalex.org/W6991315663","https://openalex.org/W2104675986","https://openalex.org/W2042696369","https://openalex.org/W2357977536","https://openalex.org/W2771993202","https://openalex.org/W2978885204","https://openalex.org/W2091641626","https://openalex.org/W7164167574"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"study":[2],"was":[3,35,75,104],"planned":[4],"to":[5],"investigate":[6],"the":[7,13,68,87,110,132,142,169,183],"effects":[8],"of":[9,44,59,102,127,146,162],"exogenous":[10],"leptin":[11,55,130,150,163,175,194],"on":[12,198],"pain":[14,72,156,180,199],"threshold.":[15],"METHODS:":[16],"Adult":[17],"male":[18],"Wistar":[19],"rats":[20],"weighing":[21,26],"250-300":[22],"g":[23,28],"and":[24,89,134,171,185],"mice":[25],"25-30":[27],"were":[29,49,65,84,94,113],"used":[30],"in":[31,41,56,117,131,155,179,206],"this":[32],"study.":[33],"Leptin":[34],"intracerebroventricularly":[36],"(i.":[37,51],"c.":[38],"v.)":[39],"injected":[40,53,66],"a":[42,57,196],"dose":[43,58],"3.5":[45],"micro":[46,61],"g/rat.":[47],"Mice":[48],"intraperitoneally":[50],"p.)":[52],"with":[54,67],"25":[60],"g/mouse.":[62],"Control":[63],"animals":[64],"respective":[69],"vehicle.":[70],"The":[71,82,92],"threshold":[73,200],"test":[74],"performed":[76,85],"using":[77],"hot":[78,118],"plate":[79,119],"analgesia":[80],"meter.":[81],"experiments":[83],"during":[86,141,168,182],"day":[88,170,184],"at":[90,106,172,186],"night.":[91,173,187],"data":[93],"statistically":[95],"analysed":[96],"by":[97],"Mann-Whitney":[98],"U":[99],"test.":[100],"Level":[101],"significance":[103],"set":[105],"p<0.05.":[107],"RESULTS:":[108],"During":[109],"day,":[111,143],"there":[112],"no":[114],"significant":[115,153],"changes":[116],"latencies":[120,165],"half":[121],"an":[122,177],"hour":[123],"after":[124],"i.c.v.":[125,144],"injection":[126,145,161],"vehicle":[128,148],"or":[129],"control":[133],"leptin-treated":[135],"rats,":[136],"respectively.":[137],"At":[138],"night,":[139],"like":[140],"neither":[147],"nor":[149],"caused":[151,176],"any":[152],"change":[154],"sensitivity.":[157],"In":[158],"mice,":[159],"i.p.":[160],"decreased":[164],"significantly":[166],"(p<0.05)":[167],"Thus,":[174],"increase":[178],"sensitivity":[181],"CONCLUSION:":[188],"These":[189],"results":[190],"clearly":[191],"demonstrated":[192],"that":[193],"has":[195],"decreasing-effect":[197],"if":[201],"it":[202],"is":[203],"peripherally":[204],"administered":[205],"mice.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}