{"id":"https://openalex.org/W2185790747","doi":null,"title":"Detection and Clinical Significance of a Potential Mediator of Airway Remodelling in Preschool Wheezy Children","display_name":"Detection and Clinical Significance of a Potential Mediator of Airway Remodelling in Preschool Wheezy Children","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2185790747","mag":"2185790747"},"language":"en","primary_location":{"id":"mag:2185790747","doi":null,"is_oa":false,"landing_page_url":"http://www.hkjpaed.org/pdf/2014;19;63-70.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090229741","display_name":"YY Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YY Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084177766","display_name":"Xe Bao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xe Bao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062483681","display_name":"Yu\u2010Shiuan Wang","orcid":"https://orcid.org/0000-0001-7204-1256","observed_orcids":["https://orcid.org/0000-0001-7204-1256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu\u2010Shiuan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7204-1256","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049399315","display_name":"Y Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/preschool-wheeze","display_name":"preschool wheeze","score":0.7059999704360962},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9610000252723694},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9750000238418579},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7829999923706055},{"id":"https://openalex.org/keywords/recurrent-wheezing","display_name":"recurrent wheezing","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pathogen-infection","display_name":"pathogen infection","score":0.7620000243186951},{"id":"https://openalex.org/keywords/immunoglobulin-e","display_name":"immunoglobulin E","score":0.847000002861023},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9520000219345093},{"id":"https://openalex.org/keywords/asthma-risk-factors","display_name":"asthma risk factors","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7383211851119995},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7349756956100464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.657114565372467},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5925353765487671},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5612756013870239},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5115176439285278},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.49782705307006836},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.48646971583366394},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4216781258583069},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763050436973572},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3408375680446625},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.063193678855896}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185790747","doi":null,"is_oa":false,"landing_page_url":"http://www.hkjpaed.org/pdf/2014;19;63-70.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W387031605","https://openalex.org/W1520017192","https://openalex.org/W1964069270","https://openalex.org/W1969193829","https://openalex.org/W1983403805","https://openalex.org/W1988277233","https://openalex.org/W1989501142","https://openalex.org/W1990544149","https://openalex.org/W1991344976","https://openalex.org/W1992870072","https://openalex.org/W1999604173","https://openalex.org/W2045404555","https://openalex.org/W2058957323","https://openalex.org/W2061575128","https://openalex.org/W2086977235","https://openalex.org/W2095076178","https://openalex.org/W2099429774","https://openalex.org/W2102175857","https://openalex.org/W2102416816","https://openalex.org/W2102997314","https://openalex.org/W2107663736","https://openalex.org/W2112162404","https://openalex.org/W2117080187","https://openalex.org/W2124127935","https://openalex.org/W2130608493","https://openalex.org/W2131770075","https://openalex.org/W2134902690","https://openalex.org/W2154369981","https://openalex.org/W2154562589","https://openalex.org/W2163738297"],"related_works":["https://openalex.org/W2051379395","https://openalex.org/W7063972759","https://openalex.org/W2328941418","https://openalex.org/W7097543260","https://openalex.org/W593559357","https://openalex.org/W2030869337","https://openalex.org/W7098596332","https://openalex.org/W2975773165","https://openalex.org/W2079893197","https://openalex.org/W2066326086"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"detect":[2],"levels":[3,32,55,68,111],"of":[4,10,33,45,56,62,69,85,100,141],"matrix":[5],"metalloproteinase":[6,11],"(MMP)-9,":[7],"tissue":[8],"inhibitors":[9],"(TIMP)-1":[12],"and":[13,20,26,36,47,60,131],"transforming":[14],"growth":[15],"factor":[16],"beta":[17],"1":[18],"(TGF-\u03b21),":[19],"analysis":[21],"the":[22,138],"relationship":[23],"among":[24],"wheezing":[25],"airway":[27,121],"remodelling-associated":[28],"factors.":[29],"Methods:":[30],"The":[31],"MMP-9,":[34],"TIMP-1":[35],"TGF-\u03b21":[37],"were":[38,50,64,71,102,112],"detected":[39],"by":[40],"enzyme-linked":[41],"immunosorbent":[42],"assay.":[43],"Samples":[44],"blood":[46],"nasopharyngeal":[48],"aspirates":[49],"analysed":[51],"for":[52,120],"pathogens.":[53],"Meanwhile,":[54],"immunoglobulin":[57],"E":[58],"(IgE)":[59],"percentage":[61],"eosinophils":[63],"measured.":[65],"Findings:":[66],"Serum":[67],"MMP-9":[70,101,110],"much":[72],"higher":[73,113],"in":[74,78,114,123],"wheezy":[75,115,124],"children":[76],"than":[77],"controls":[79],"(p":[80],"0.05).":[81],"No":[82],"significant":[83],"effects":[84],"recurrent":[86,127],"wheezing,":[87,128],"pathogen":[88,129],"infection,":[89],"IgE":[90],"level":[91,99,140],"or":[92],"asthma":[93],"high":[94],"risk":[95],"factors":[96],"on":[97,137],"serum":[98,109,139],"observed":[103],"(p>0.05).":[104],"Conclusion:":[105],"We":[106],"found":[107],"that":[108],"children,":[116],"indicating":[117],"a":[118],"possibility":[119],"remodelling":[122],"children.":[125],"However,":[126],"infection":[130],"hereditary":[132],"backgrounds":[133],"had":[134],"no":[135],"effect":[136],"MMP-9.":[142]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
