{"id":"https://openalex.org/W2185727768","doi":null,"title":"Antihyperlipidemic Activity of Rimonabant on High Cholesterol Diet Induced Hyperlipidemia in Rats","display_name":"Antihyperlipidemic Activity of Rimonabant on High Cholesterol Diet Induced Hyperlipidemia in Rats","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2185727768","mag":"2185727768"},"language":"en","primary_location":{"id":"mag:2185727768","doi":null,"is_oa":false,"landing_page_url":"https://pharmacologyonline.silae.it/files/archives/2011/vol1/124.arshad.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083511802","display_name":"Arshad Alioorani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arshad Alioorani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gaurav Dwivedi","orcid":"https://orcid.org/0000-0003-0681-0795","observed_orcids":["https://orcid.org/0000-0003-0681-0795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurav Dwivedi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0681-0795","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089919111","display_name":"Mayura A. Kale","orcid":"https://orcid.org/0000-0002-7124-6716","observed_orcids":["https://orcid.org/0000-0002-7124-6716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mayura Kale","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7124-6716","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4294,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71987179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rimonabant","display_name":"rimonabant","score":1.0},{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.9959999918937683},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.9179999828338623},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9509999752044678},{"id":"https://openalex.org/keywords/atherogenic-index","display_name":"atherogenic index","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aortic-plaque","display_name":"aortic plaque","score":0.8730000257492065},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.906000018119812},{"id":"https://openalex.org/keywords/cannabinoid-receptor-antagonists","display_name":"cannabinoid receptor antagonists","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.8658981323242188},{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.8298343420028687},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.716396152973175},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.7143741846084595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6838503479957581},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6604427695274353},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.5230584740638733},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.48219791054725647},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.45434945821762085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44534438848495483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42056798934936523},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.23885226249694824},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.19490253925323486},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.08089709281921387},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07278689742088318},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.06862536072731018}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185727768","doi":null,"is_oa":false,"landing_page_url":"https://pharmacologyonline.silae.it/files/archives/2011/vol1/124.arshad.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W165443073","https://openalex.org/W1964299529","https://openalex.org/W1966840102","https://openalex.org/W2025139995","https://openalex.org/W2041247294","https://openalex.org/W2074855794","https://openalex.org/W2085099697","https://openalex.org/W2087587748","https://openalex.org/W2155810130"],"related_works":["https://openalex.org/W2387061760","https://openalex.org/W7204246617","https://openalex.org/W2885816808","https://openalex.org/W417996154","https://openalex.org/W2163895712","https://openalex.org/W1997133986","https://openalex.org/W1968211286","https://openalex.org/W7095131872","https://openalex.org/W4404812098","https://openalex.org/W2887348019"],"abstract_inverted_index":{"Summary":[0],"Hyperlipidemia":[1,32],"is":[2],"defined":[3],"as":[4,137,152],"increase":[5,64,110],"in":[6,10,30,52,66,96,134],"the":[7,19,82,116,121,146],"lipid":[8],"content":[9],"blood.":[11],"The":[12,113],"present":[13],"study":[14,128,147],"was":[15,33,118],"conducted":[16],"to":[17,120,139],"evaluate":[18],"antihyperlipidemic":[20,154],"activity":[21,114],"of":[22,79,86,115],"rimonabant":[23,83,117,131,150],"on":[24,58],"high":[25,37,59,140],"cholesterol":[26,38,60,141],"diet":[27,39,61,142],"induced":[28,34],"hyperlipidemia":[29],"rats.":[31,144],"by":[35],"giving":[36],"(2%":[40],"cholesterol,":[41,68,103],"1%":[42],"sodium":[43],"cholate":[44],"and":[45,74,89,98,101,109],"2%":[46],"coconut":[47],"oil)":[48],"for":[49],"thirty":[50],"days":[51],"standard":[53,122],"rat":[54],"chow":[55],"diet.":[56],"Rats":[57],"showed":[62,92,129],"significant":[63,93],"(p<0.05)":[65,95],"serum":[67,97,100],"triglyceride":[69],"LDL-C,":[70,105],"VLDL-C,":[71,106],"atherogenic":[72,107],"index":[73,108],"decrease":[75,94,133],"HDL-C":[76,111],"levels.":[77,112],"Pretreatment":[78],"rats":[80],"with":[81],"at":[84],"doses":[85],"2.5,":[87],"5":[88],"10":[90],"mg/kg":[91],"tissue":[99,102],"triglyceride,":[104],"comparable":[119],"drug,":[123],"simvastatin":[124],"(4mg/kg,":[125],"p.o.).":[126],"Histological":[127],"that":[130,149],"caused":[132],"aortic":[135],"plaque":[136],"compared":[138],"fed":[143],"Thus":[145],"demonstrates":[148],"effective":[151],"an":[153],"agent.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}