{"id":"https://openalex.org/W2185652292","doi":"https://doi.org/10.1016/s0022-2275(20)39784-4","title":"Non-sterol regulation of low density lipoprotein receptor gene expression in T cells","display_name":"Non-sterol regulation of low density lipoprotein receptor gene expression in T cells","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2185652292","doi":"https://doi.org/10.1016/s0022-2275(20)39784-4","mag":"2185652292","pmid":"https://pubmed.ncbi.nlm.nih.gov/7852866"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)39784-4","doi":"https://doi.org/10.1016/s0022-2275(20)39784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)39784-4","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0022-2275(20)39784-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024470540","display_name":"Robert S.J. Makar","orcid":"https://orcid.org/0000-0001-7420-2631","observed_orcids":["https://orcid.org/0000-0001-7420-2631"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Makar","raw_affiliation_strings":["Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas 75235-8887"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas 75235-8887","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P E Lipsky","raw_affiliation_strings":["University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007342242","display_name":"Jennifer A. Cuthbert","orcid":"https://orcid.org/0000-0002-8413-2128","observed_orcids":["https://orcid.org/0000-0002-8413-2128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Cuthbert","raw_affiliation_strings":["Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.1743,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.88416544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"35","issue":"10","first_page":"1888","last_page":"1895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mitogenic-stimulation","display_name":"mitogen stimulation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anisomycin","display_name":"anisomycin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/puromycin","display_name":"puromycin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mrna-half-life","display_name":"mRNA half-life","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.7049999833106995},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8960000276565552},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sterol-regulation","display_name":"sterol regulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/ldl-receptor-mrna","display_name":"LDL receptor mRNA","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.6317795515060425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5816876292228699},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.5350149273872375},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4483463168144226},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.411819189786911},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38863322138786316},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.3820624351501465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37544727325439453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3353036642074585},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.32333648204803467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3012329638004303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29024264216423035}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015759","descriptor_name":"Ionomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)39784-4","doi":"https://doi.org/10.1016/s0022-2275(20)39784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)39784-4","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:7852866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7852866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:018229f7c2c242f4a53d8d4ed5667845","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/018229f7c2c242f4a53d8d4ed5667845","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 35, Iss 10, Pp 1888-1895 (1994)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)39784-4","doi":"https://doi.org/10.1016/s0022-2275(20)39784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)39784-4","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1578869400","display_name":"STEROL METABOLISM AND HUMAN MONONUCLEAR CELL FUNCTION","funder_award_id":"5r01ai017653-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5222145888","display_name":null,"funder_award_id":"AI-17653","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W216009453","https://openalex.org/W1488441381","https://openalex.org/W1520525371","https://openalex.org/W1543180486","https://openalex.org/W1549496586","https://openalex.org/W1549703942","https://openalex.org/W1597236414","https://openalex.org/W1605729052","https://openalex.org/W1625442594","https://openalex.org/W1627093987","https://openalex.org/W1631424226","https://openalex.org/W1657550065","https://openalex.org/W1658669968","https://openalex.org/W1760280961","https://openalex.org/W1910815336","https://openalex.org/W1939621698","https://openalex.org/W1965713890","https://openalex.org/W1965867424","https://openalex.org/W1982598173","https://openalex.org/W2010356985","https://openalex.org/W2063767041","https://openalex.org/W2065956596","https://openalex.org/W2081468422","https://openalex.org/W2107359522","https://openalex.org/W2134812217","https://openalex.org/W2161959951","https://openalex.org/W2406372236","https://openalex.org/W4294216491"],"related_works":["https://openalex.org/W2406372236","https://openalex.org/W2188779270","https://openalex.org/W2430766663","https://openalex.org/W1901961448","https://openalex.org/W1657550065","https://openalex.org/W1549496586","https://openalex.org/W2414456229","https://openalex.org/W2119665952","https://openalex.org/W2404641809","https://openalex.org/W1939621698"],"abstract_inverted_index":{"Non-sterol":[0],"regulation":[1,249],"of":[2,20,49,60,83,121,134,181,190,211,228,250],"low":[3],"density":[4],"lipoprotein":[5],"(LDL)":[6],"receptor":[7,45,62,72,103,123,136,153,167,206,214,252],"gene":[8,78,93,137,168,207,215,253],"expression":[9,94],"was":[10,95,109,129],"examined":[11],"in":[12,58,70,97,126,186,247],"a":[13,162,226],"mitogen-responsive":[14],"human":[15],"T":[16,23],"cell":[17,24],"line.":[18],"Stimulation":[19],"the":[21,28,36,114,197,212,232],"leukemic":[22],"line":[25],"Jurkat":[26,98,127],"with":[27,52,101],"phorbol":[29,31],"ester":[30],"12-myristate":[32],"13-acetate":[33],"(PMA)":[34],"and":[35,41,106,144,193,202],"calcium":[37],"ionophore":[38],"ionomycin":[39],"rapidly":[40],"transiently":[42],"increased":[43,77],"LDL":[44,61,71,102,122,135,152,166,205,213,251],"mRNA":[46,63,73,84,107,124,154],"levels.":[47],"Inhibition":[48],"protein":[50,140,182,191,198],"synthesis":[51,141,199],"cycloheximide":[53],"(CHX)":[54],"or":[55,236],"puromycin":[56],"resulted":[57,75],"superinduction":[59,120],"levels":[64,74,125],"by":[65,113,131,196,220,225],"mitogenic":[66,117],"stimulation.":[67],"The":[68,139],"increase":[69],"from":[76],"transcription":[79,210],"rather":[80],"than":[81],"stabilization":[82],"half-life.":[85],"Thus,":[86,209],"similar":[87],"results":[88],"were":[89],"obtained":[90],"when":[91],"reporter":[92],"assessed":[96],"cells":[99,128],"transfected":[100],"promoter":[104],"constructs":[105],"half-life":[108],"not":[110,147,217],"significantly":[111],"altered":[112],"stimuli.":[115],"Neither":[116],"induction":[118],"nor":[119],"prevented":[130],"sterol":[132],"downregulation":[133],"expression.":[138,208,254],"inhibitors":[142,200],"CHX":[143,201],"anisomycin,":[145,203],"but":[146,223],"puromycin,":[148],"also":[149,224],"directly":[150],"stimulated":[151],"levels,":[155],"suggesting":[156],"that":[157,175,230],"these":[158,172],"compounds":[159],"could":[160],"provide":[161],"signal":[163],"required":[164],"for":[165],"transcription.":[169],"Taken":[170],"together,":[171],"data":[173],"indicate":[174],"various":[176,233],"non-sterol":[177],"stimuli,":[178],"including":[179],"activation":[180],"kinase":[183],"C,":[184],"increases":[185],"intracellular":[187],"calcium,":[188],"inhibition":[189],"synthesis,":[192],"signals":[194],"generated":[195],"induce":[204],"is":[216],"only":[218],"regulated":[219],"ambient":[221],"sterols":[222],"variety":[227],"influences":[229],"govern":[231],"primary":[234],"response":[235],"immediate":[237],"early":[238],"genes.":[239],"These":[240],"stimuli":[241],"may":[242],"play":[243],"an":[244],"important":[245],"role":[246],"normal":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
