{"id":"https://openalex.org/W2185569201","doi":null,"title":"Management of acute severe asthma.","display_name":"Management of acute severe asthma.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2185569201","mag":"2185569201","pmid":"https://pubmed.ncbi.nlm.nih.gov/25327055"},"language":"en","primary_location":{"id":"pmid:25327055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25327055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113094374","display_name":"A G Unnikrishnan","orcid":"https://orcid.org/0000-0001-7603-9639","observed_orcids":["https://orcid.org/0000-0001-7603-9639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A G Unnikrishnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049789523","display_name":"Ganapathi Bantwal","orcid":"https://orcid.org/0000-0003-4343-1719","observed_orcids":["https://orcid.org/0000-0003-4343-1719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ganapathi Bantwal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5141751493","display_name":"R K Sahay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K Sahay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8716,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7265044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"62","issue":"1 Suppl","first_page":"15","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.3416000008583069,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-severe-asthma","display_name":"status asthmaticus","score":0.8550000190734863},{"id":"https://openalex.org/keywords/asthma-management","display_name":"asthma management","score":0.9100000262260437},{"id":"https://openalex.org/keywords/insulin-degludec","display_name":"insulin degludec","score":0.925000011920929},{"id":"https://openalex.org/keywords/basal-insulin","display_name":"basal insulin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":0.7689999938011169},{"id":"https://openalex.org/keywords/insulin-pharmacokinetics","display_name":"insulin pharmacokinetics","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hypoglycemia-risk","display_name":"hypoglycemia risk","score":0.8930000066757202},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9020000100135803},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0}],"concepts":[{"id":"https://openalex.org/C2775927303","wikidata":"https://www.wikidata.org/wiki/Q16252338","display_name":"Insulin degludec","level":5,"score":0.9162602424621582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8100152015686035},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7941455841064453},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.7471630573272705},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.603652834892273},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5523562431335449},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5389208793640137},{"id":"https://openalex.org/C2909524832","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Basal insulin","level":4,"score":0.527141809463501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4915555417537689},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45827245712280273},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4018581211566925},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.2511833906173706}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013224","descriptor_name":"Status Asthmaticus","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013224","descriptor_name":"Status Asthmaticus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013224","descriptor_name":"Status Asthmaticus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:25327055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25327055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"},{"id":"pmid:25330627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25330627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"},{"id":"mag:2185569201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25330627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1565099151","https://openalex.org/W1967655470","https://openalex.org/W1974288288","https://openalex.org/W1976721638","https://openalex.org/W1991838831","https://openalex.org/W1995575266","https://openalex.org/W2009468057","https://openalex.org/W2050756416","https://openalex.org/W2054086723","https://openalex.org/W2105912552","https://openalex.org/W2136164787","https://openalex.org/W2204634826","https://openalex.org/W2319053745","https://openalex.org/W2332952334"],"related_works":["https://openalex.org/W2147715278","https://openalex.org/W2183729207","https://openalex.org/W1974288288","https://openalex.org/W1996750987","https://openalex.org/W2356750798","https://openalex.org/W6995628952","https://openalex.org/W2102619124","https://openalex.org/W1997529585","https://openalex.org/W2041226218","https://openalex.org/W2388140613"],"abstract_inverted_index":{"There":[0],"is":[1,33,139,152,172,203],"a":[2,15,21,38,53,156,200],"need":[3,13],"for":[4,26,91,198,248],"ideal":[5],"basal":[6,60,147,216],"insulin":[7,36,80,92,115,161,169,182,217],"which":[8,138],"can":[9],"overcome":[10],"the":[11,58,75,131,145,177,184,196,206,222,242],"unmet":[12],"of":[14,29,41,43,79,95,112,114,134,181,186,208,214,221,245,252],"truly":[16],"once":[17],"daily":[18],"insulin,":[19],"with":[20,37,64,69,144,160,228,241],"flat":[22,54,224],"peakless":[23],"profile.":[24],"Useful":[25],"all":[27],"types":[28],"patients":[30,63],"Insulin":[31],"degludec":[32,81,116,162],"next":[34],"generation":[35],"unique":[39,132],"mode":[40],"protraction":[42],"forming":[44],"soluble":[45],"multi-hexamers":[46],"and":[47,128,183,190,210,225,232],"slow":[48],"continuous":[49],"absorption":[50,209],"giving":[51],"it":[52,102],"profile":[55,227],"compared":[56],"to":[57,119],"existing":[59,146],"insulin.":[61,148],"In":[62,98],"type":[65,70],"1":[66],"diabetes":[67],"or":[68],"2":[71],"diabetes,":[72],"at":[73],"steady-state,":[74],"mean":[76],"terminal":[77],"half-life":[78],"was":[82,117],"25":[83],"hours,":[84],"i.e.,":[85],"approximately":[86,107],"twice":[87],"as":[88,90],"long":[89],"glargine":[93],"(half-life":[94],"12.1":[96],"hours).":[97],"once-daily":[99],"dosing":[100,137,158],"regimen":[101],"reaches":[103],"steady":[104],"state":[105],"after":[106],"3":[108],"days.":[109],"The":[110,149,219],"duration":[111],"action":[113],"estimated":[118],"be":[120],"beyond":[121],"42":[122],"hours":[123],"in":[124],"euglycaemic":[125],"clamp":[126],"studies":[127],"this":[129],"gives":[130],"opportunity":[133],"flexible":[135],"time":[136,189],"not":[140],"an":[141,173,229,237],"available":[142],"option":[143],"glucose-lowering":[150],"effect":[151],"evenly":[153],"distributed":[154],"across":[155],"24-hour":[157],"interval":[159],"having":[163],"4":[164],"times":[165],"lower":[166,211,243],"variability":[167,207,234],"than":[168],"glargine.":[170],"This":[171],"important":[174],"attribute":[175],"given":[176,205],"narrow":[178],"therapeutic":[179],"window":[180],"goal":[185,201],"achieving":[187],"night":[188],"inter-prandial":[191],"glycaemic":[192,253],"control":[193],"without":[194],"increasing":[195],"risk":[197,244],"hypoglycaemia,":[199,246],"that":[202],"challenging":[204],"PK":[212],"half-lives":[213],"current":[215],"products.":[218],"combination":[220],"ultra-long,":[223],"stable":[226],"improved":[230,238,250],"hour-to-hour":[231],"day-to-day":[233],"could":[235],"present":[236],"risk-benefit":[239],"trade-off":[240],"allowing":[247],"targeting":[249],"levels":[251],"control.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
