{"id":"https://openalex.org/W2185544995","doi":null,"title":"Antitumor-promoting activity of lignans: inhibition of human cytomegalovirus IE gene expression.","display_name":"Antitumor-promoting activity of lignans: inhibition of human cytomegalovirus IE gene expression.","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2185544995","mag":"2185544995","pmid":"https://pubmed.ncbi.nlm.nih.gov/20332453"},"language":"en","primary_location":{"id":"pmid:20332453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20332453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011398185","display_name":"Roz\u00e1lia Pusztai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Roz\u00e1lia Pusztai","raw_affiliation_strings":["Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marta Abrantes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Abrantes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Julianna Serly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julianna Serly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091047165","display_name":"Julia Sherly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Sherly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004467608","display_name":"No\u00e9lia Duarte","orcid":"https://orcid.org/0000-0003-3119-8745","observed_orcids":["https://orcid.org/0000-0003-3119-8745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"No\u00e9lia Duarte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058006275","display_name":"Joseph Andrew Molnar","orcid":"https://orcid.org/0000-0003-2254-6269","observed_orcids":["https://orcid.org/0000-0003-2254-6269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Molnar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024790937","display_name":"Maria\u2010Jos\u00e9 U. Ferreira","orcid":"https://orcid.org/0000-0002-8742-1486","observed_orcids":["https://orcid.org/0000-0002-8742-1486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria-Jos\u00e9 U Ferreira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5308,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.57899474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"2","first_page":"451","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11208","display_name":"Lignin and Wood Chemistry","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1508","display_name":"Process Chemistry and Technology"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lignans","display_name":"lignans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-tumor-promoting-activity","display_name":"antitumor-promoting activity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9129999876022339},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lung-cancer-cells","display_name":"lung cancer cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hinokinin","display_name":"hinokinin","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7626476883888245},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6337999105453491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5988247990608215},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46208783984184265},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46083906292915344},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.45125094056129456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42573392391204834},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4166179299354553},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38663339614868164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32261642813682556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21983659267425537},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18066391348838806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1310553252696991}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026324","descriptor_name":"Myristicaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20332453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20332453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9923999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1965965261","https://openalex.org/W2009449595","https://openalex.org/W2013877689","https://openalex.org/W2023650844","https://openalex.org/W2046704995","https://openalex.org/W2049693838","https://openalex.org/W2055123928","https://openalex.org/W2065883537","https://openalex.org/W2091025707","https://openalex.org/W2098816998","https://openalex.org/W2113999888","https://openalex.org/W2123000264","https://openalex.org/W2130272830","https://openalex.org/W2145145182","https://openalex.org/W2150793976","https://openalex.org/W2152723616"],"related_works":["https://openalex.org/W1988716468","https://openalex.org/W2557867929","https://openalex.org/W2079611140","https://openalex.org/W2885621202","https://openalex.org/W2140201275","https://openalex.org/W2025808503","https://openalex.org/W2072792139","https://openalex.org/W179874853","https://openalex.org/W6997994080","https://openalex.org/W2063911901"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chemoprevention":[1],"is":[2],"a":[3,87],"promising":[4],"new":[5],"approach":[6],"to":[7,56],"cancer":[8,65,117],"prevention.":[9],"Since":[10],"the":[11,22,30,71,79,97],"beginning":[12],"of":[13,24,32,70,77,91,103,109],"chemoprevention":[14],"studies,":[15],"short-term":[16],"in":[17,21,29,63],"vitro":[18],"models":[19],"used":[20],"study":[23,105],"carcinogenesis":[25],"have":[26],"been":[27],"applied":[28],"identification":[31],"antitumor-promoting":[33],"agents.":[34,119],"MATERIALS":[35],"AND":[36],"METHODS:":[37],"The":[38,101],"lignans":[39,111],"threo-4,4'-dihydroxy-3-methoxylignan,":[40],"(-)-dihydroguaiaretic":[41],"acid,":[42],"4'-hydroxy-3,3',4-trimethoxylignan,":[43],"3,3',4,4'-tetramethoxylignan,":[44],"4,4'-diacetyl-3,3'-dimethoxylignan,":[45],"talaumidin,":[46],"heliobuphthalmin,":[47],"(-)-dihydro-cubebin,":[48],"and":[49],"hinokinin":[50],"were":[51],"evaluated":[52,72],"for":[53,96],"their":[54],"ability":[55],"inhibit":[57],"human":[58],"cytomegalovirus":[59],"(HCMV)":[60],"IE-antigen":[61,75,92],"expression":[62,76,93],"lung":[64],"cells":[66],"(A549).":[67],"RESULTS:":[68],"Most":[69],"compounds":[73],"reduced":[74],"HCMV,":[78],"best":[80],"result":[81],"being":[82],"obtained":[83],"with":[84],"4,4'-dihydroxy-3-methoxylignan.":[85],"However,":[86],"dose-dependent":[88],"significant":[89],"increase":[90],"was":[94],"found":[95],"derivative":[98],"(-)-dihydrocubebin.":[99],"CONCLUSION:":[100],"results":[102],"this":[104],"suggest":[106],"that":[107],"some":[108],"these":[110],"might":[112],"be":[113],"valuable":[114],"as":[115],"potential":[116],"chemopreventive":[118]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}