{"id":"https://openalex.org/W2185544520","doi":null,"title":"Pepsin Promotes Proliferation of Laryngeal and Pharyngeal","display_name":"Pepsin Promotes Proliferation of Laryngeal and Pharyngeal","publication_year":2016,"publication_date":"2016-09-16","ids":{"openalex":"https://openalex.org/W2185544520","mag":"2185544520"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.889.7936","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.889.7936","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Nikki_Johnston2/publication/224926204_Pepsin_promotes_proliferation_of_laryngeal_and_pharyngeal_epithelial_cells/links/0f317531752a4741a7000000.pdf","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022032922","display_name":"Nikki Johnston","orcid":"https://orcid.org/0000-0003-4750-7637","observed_orcids":["https://orcid.org/0000-0003-4750-7637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikki Johnston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078117282","display_name":"Tina L. Samuels","orcid":"https://orcid.org/0000-0002-7045-357X","observed_orcids":["https://orcid.org/0000-0002-7045-357X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina Samuels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032442574","display_name":"Gary D. Stoner","orcid":"https://orcid.org/0000-0002-7888-5609","observed_orcids":["https://orcid.org/0000-0002-7888-5609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary D Stoner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091771512","display_name":"Joel H. Blumin","orcid":"https://orcid.org/0000-0003-2927-4032","observed_orcids":["https://orcid.org/0000-0003-2927-4032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Blumin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Epithelial Cells","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Epithelial Cells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nikki Johnston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikki Johnston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Phd Justin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phd Justin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C. Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bs Craig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bs Craig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R. Hoekzema","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Hoekzema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bs Tina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bs Tina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L. Samuels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Samuels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00168936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pepsin","display_name":"pepsin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/laryngopharyngeal-reflux","display_name":"laryngopharyngeal reflux","score":0.9890000224113464},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pharyngeal-squamous-cell-carcinoma","display_name":"pharyngeal squamous cell carcinoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fadu-cells","display_name":"FaDu cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.871999979019165},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.8283692598342896},{"id":"https://openalex.org/C2780897648","wikidata":"https://www.wikidata.org/wiki/Q367616","display_name":"Laryngopharyngeal reflux","level":4,"score":0.8221262693405151},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6486891508102417},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4835667312145233},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4775272607803345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4597504436969757},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.45029354095458984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44610846042633057},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.43087801337242126},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42436981201171875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4068297743797302},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3822864592075348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37725093960762024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3240453004837036},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26242387294769287},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.24925589561462402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09737053513526917},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0807153582572937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07146784663200378},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.889.7936","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.889.7936","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Nikki_Johnston2/publication/224926204_Pepsin_promotes_proliferation_of_laryngeal_and_pharyngeal_epithelial_cells/links/0f317531752a4741a7000000.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W102196872","https://openalex.org/W217485724","https://openalex.org/W1460451554","https://openalex.org/W1501958067","https://openalex.org/W1565457160","https://openalex.org/W1568175950","https://openalex.org/W1596561915","https://openalex.org/W1910791907","https://openalex.org/W1974486888","https://openalex.org/W1975903826","https://openalex.org/W1976522267","https://openalex.org/W1983359495","https://openalex.org/W1992921775","https://openalex.org/W1993865814","https://openalex.org/W1997013285","https://openalex.org/W2003579259","https://openalex.org/W2004569804","https://openalex.org/W2011310913","https://openalex.org/W2014640407","https://openalex.org/W2022827269","https://openalex.org/W2028609150","https://openalex.org/W2031107250","https://openalex.org/W2035386878","https://openalex.org/W2036743876","https://openalex.org/W2059142153","https://openalex.org/W2075008048","https://openalex.org/W2083966895","https://openalex.org/W2102888413","https://openalex.org/W2105260398","https://openalex.org/W2117566166","https://openalex.org/W2132751868","https://openalex.org/W2133061403","https://openalex.org/W2134906059","https://openalex.org/W2154559208","https://openalex.org/W2156945612","https://openalex.org/W2162578510","https://openalex.org/W2164158213","https://openalex.org/W2331927466"],"related_works":["https://openalex.org/W2125543848","https://openalex.org/W2322928624","https://openalex.org/W4414812168","https://openalex.org/W3000613737","https://openalex.org/W2996379046","https://openalex.org/W3044139737","https://openalex.org/W2524712537","https://openalex.org/W3012884465","https://openalex.org/W4292987203","https://openalex.org/W2090947706"],"abstract_inverted_index":{"Objective/Hypothesis:":[0],"Laryngopharyngeal":[1],"reflux":[2,29,70],"(LPR)":[3],"is":[4,25],"thought":[5],"to":[6,65,99,116,170],"be":[7,171],"a":[8,204,231],"significant":[9],"risk":[10,43],"factor":[11],"for":[12,54,137,233],"laryngeal":[13,87,190,217],"squamous":[14],"cell":[15,90],"carcinoma":[16],"(SCC),":[17],"but":[18,47],"causality":[19],"has":[20],"never":[21],"been":[22,52],"proven.":[23],"It":[24],"accepted":[26],"that":[27,69,149],"chronic":[28],"into":[30,73],"the":[31,67,74,118,138,153,164,237,245],"esophagus":[32],"can":[33,76],"induce":[34],"metaplastic":[35],"changes":[36],"in":[37,159,173,182,203,213,221,236],"esophageal":[38,45],"mucosa":[39],"with":[40],"subsequent":[41],"increased":[42,180],"of":[44,61,71,120,140,155,166,239,244],"adenocarcinoma,":[46],"no":[48],"similar":[49],"associations":[50],"have":[51],"established":[53],"LPR":[55],"and":[56,92,102,108,113,131,161,176,187,206,242,247],"laryngopharyngeal":[57],"SCC.":[58],"The":[59],"objective":[60],"this":[62],"study":[63],"was":[64,211],"test":[66],"hypothesis":[68],"pepsin":[72,101,121,141,150,210,235],"laryngopharynx":[75],"promote":[77],"carcinogenesis.":[78,123],"Study":[79],"Design:":[80],"Translational":[81],"research":[82],"study.":[83],"Methods:":[84],"Normal":[85],"human":[86,100,174,216],"primary":[88,192],"epithelial":[89,191,240],"cultures":[91],"hypopharyngeal":[93],"FaDu":[94,184],"SCC":[95,185],"cells":[96,186,193],"were":[97,135],"exposed":[98],"analyzed":[103,136],"by":[104,142,194],"Human":[105],"Cancer":[106],"PathwayFinder":[107],"miRNA":[109],"Superarrays,":[110],"flow":[111,200],"cytometry,":[112],"Western":[114,143],"blot":[115],"determine":[117],"effect":[119],"on":[122,199],"Laryngeal":[124],"biopsy":[125],"specimens":[126],"taken":[127],"from":[128],"cancer":[129,218],"patients":[130],"normal":[132,189,224],"control":[133,225],"subjects":[134],"presence":[139],"blot.":[144],"Results:":[145],"Microarray":[146],"analysis":[147,202],"demonstrated":[148],"significantly":[151],"altered":[152,172],"expression":[154,165],"27":[156],"genes":[157],"implicated":[158],"carcinogenesis":[160,243],"also":[162],"affected":[163],"22":[167],"microRNAs":[168],"known":[169],"head":[175],"neck":[177],"cancers.":[178],"Pepsin":[179],"proliferation":[181,241],"both":[183],"cultured":[188],"increasing":[195],"S":[196],"phase":[197],"distribution":[198],"cytometry":[201],"time-":[205],"dose-dependent":[207],"manner.":[208],"Furthermore,":[209],"detected":[212],"60%":[214],"(3/5)":[215],"biopsies,":[219],"absent":[220],"all":[222],"(0/5)":[223],"specimens.":[226],"Conclusions:":[227],"These":[228],"data":[229],"support":[230],"role":[232],"refluxed":[234],"promotion":[238],"larynx":[246],"pharynx.":[248]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-27T00:00:00"}
