{"id":"https://openalex.org/W2185441571","doi":null,"title":"HEMATOPOIETIC GROWTH FACTORS AS BIOPHARMACEUTICALS: AN OVERVIEW","display_name":"HEMATOPOIETIC GROWTH FACTORS AS BIOPHARMACEUTICALS: AN OVERVIEW","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2185441571","mag":"2185441571"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.735.8632","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.735.8632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.pharmacophorejournal.com/March-April2012-article1.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014101361","display_name":"Alemu Tekewe Mogus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4537092","display_name":"Addis Ababa University","ror":"https://ror.org/038b8e254","country_code":"ET","type":"education","lineage":["https://openalex.org/I4537092"]}],"countries":["ET"],"is_corresponding":true,"raw_author_name":"Alemu Tekewe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014101361"],"corresponding_institution_ids":["https://openalex.org/I4537092"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":1.0},{"id":"https://openalex.org/keywords/biopharmaceuticals","display_name":"biopharmaceuticals","score":0.9300000071525574},{"id":"https://openalex.org/keywords/recombinant-human-erythropoietin","display_name":"recombinant human erythropoietin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9810000061988831},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/therapeutic-use","display_name":"therapeutic applications","score":0.781000018119812},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.8454651832580566},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.7863896489143372},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7566291689872742},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.6083679795265198},{"id":"https://openalex.org/C2779958370","wikidata":"https://www.wikidata.org/wiki/Q5711176","display_name":"Hematopoietic growth factor","level":4,"score":0.4926043152809143},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4904927611351013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47706639766693115},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.44813284277915955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4464268386363983},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.42235875129699707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3905164897441864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33577483892440796},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3015702962875366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16815930604934692},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11633720993995667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08965829014778137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08944639563560486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06603792309761047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.735.8632","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.735.8632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.pharmacophorejournal.com/March-April2012-article1.pdf","raw_type":"text"},{"id":"mag:2185441571","doi":null,"is_oa":false,"landing_page_url":"http://www.pharmacophorejournal.com/March-April2012-article1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":118,"referenced_works":["https://openalex.org/W135664608","https://openalex.org/W560011515","https://openalex.org/W1509263437","https://openalex.org/W1964442822","https://openalex.org/W1966282629","https://openalex.org/W1966441019","https://openalex.org/W1966491512","https://openalex.org/W1966589434","https://openalex.org/W1969026212","https://openalex.org/W1970174884","https://openalex.org/W1971676333","https://openalex.org/W1971905226","https://openalex.org/W1972327301","https://openalex.org/W1972565961","https://openalex.org/W1975871632","https://openalex.org/W1979395058","https://openalex.org/W1979759645","https://openalex.org/W1982202983","https://openalex.org/W1982753930","https://openalex.org/W1987828803","https://openalex.org/W1988125179","https://openalex.org/W1988373179","https://openalex.org/W1989616697","https://openalex.org/W1991532167","https://openalex.org/W1994465803","https://openalex.org/W1995234557","https://openalex.org/W1997451316","https://openalex.org/W1997669708","https://openalex.org/W1998307883","https://openalex.org/W2001182608","https://openalex.org/W2001395360","https://openalex.org/W2002352686","https://openalex.org/W2002605289","https://openalex.org/W2003813764","https://openalex.org/W2004179421","https://openalex.org/W2004611408","https://openalex.org/W2007118810","https://openalex.org/W2008431257","https://openalex.org/W2008631422","https://openalex.org/W2008988352","https://openalex.org/W2009482658","https://openalex.org/W2011567131","https://openalex.org/W2011704747","https://openalex.org/W2011951268","https://openalex.org/W2012781921","https://openalex.org/W2017702900","https://openalex.org/W2020602778","https://openalex.org/W2021467368","https://openalex.org/W2025086383","https://openalex.org/W2034196461","https://openalex.org/W2036236332","https://openalex.org/W2038148110","https://openalex.org/W2045181918","https://openalex.org/W2048509719","https://openalex.org/W2048765632","https://openalex.org/W2049322319","https://openalex.org/W2049578196","https://openalex.org/W2052188108","https://openalex.org/W2052829077","https://openalex.org/W2053203479","https://openalex.org/W2056426485","https://openalex.org/W2057592439","https://openalex.org/W2060832204","https://openalex.org/W2061302713","https://openalex.org/W2064607395","https://openalex.org/W2064635248","https://openalex.org/W2065035248","https://openalex.org/W2065194672","https://openalex.org/W2068868898","https://openalex.org/W2069498258","https://openalex.org/W2069937695","https://openalex.org/W2069943302","https://openalex.org/W2070169917","https://openalex.org/W2073929484","https://openalex.org/W2075553774","https://openalex.org/W2076836963","https://openalex.org/W2076893351","https://openalex.org/W2076955936","https://openalex.org/W2079689214","https://openalex.org/W2081153769","https://openalex.org/W2081786869","https://openalex.org/W2082281829","https://openalex.org/W2083780169","https://openalex.org/W2084046603","https://openalex.org/W2085602292","https://openalex.org/W2086108159","https://openalex.org/W2086486213","https://openalex.org/W2087784094","https://openalex.org/W2090519754","https://openalex.org/W2093775751","https://openalex.org/W2102607365","https://openalex.org/W2107995406","https://openalex.org/W2109197670","https://openalex.org/W2116047361","https://openalex.org/W2119568588","https://openalex.org/W2120615618","https://openalex.org/W2141624030","https://openalex.org/W2142984634","https://openalex.org/W2143977369","https://openalex.org/W2147092831","https://openalex.org/W2153903059","https://openalex.org/W2153989822","https://openalex.org/W2155325844","https://openalex.org/W2157564301","https://openalex.org/W2162703233","https://openalex.org/W2165311757","https://openalex.org/W2168576401","https://openalex.org/W2169203358","https://openalex.org/W2169282371","https://openalex.org/W2171896200","https://openalex.org/W2185123273","https://openalex.org/W2338763359","https://openalex.org/W2344996637","https://openalex.org/W2413547524","https://openalex.org/W2415780251","https://openalex.org/W4237682739","https://openalex.org/W4243226078","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7097639239","https://openalex.org/W155992435","https://openalex.org/W2418807451","https://openalex.org/W2413617251","https://openalex.org/W4248042361","https://openalex.org/W104218886","https://openalex.org/W2419296202","https://openalex.org/W2226858624","https://openalex.org/W1965805605","https://openalex.org/W2395479920"],"abstract_inverted_index":{"For":[0],"the":[1,5,18,35,46,55,97,107,140,151,156,168,173,179],"past":[2],"four":[3],"decades,":[4],"application":[6],"of":[7,22,37,57,60,102,110,155,167,172,176,178],"recombinant":[8,108,174],"DNA":[9],"technology":[10],"and":[11,52,82,100,113,126,144,164],"other":[12,145],"novel":[13],"allied":[14],"technologies":[15],"has":[16],"opened":[17],"door":[19],"for":[20,34,54,88,93,118],"production":[21],"many":[23,38,119],"proteins":[24],"in":[25,96,121,124,139],"large":[26],"quantities":[27],"that":[28,49,132],"have":[29,50,85,115,134],"become":[30],"important":[31,136],"new":[32],"biopharmaceuticals":[33,48],"treatment":[36,56],"diseases.":[39,61],"Hematopoietic":[40],"growth":[41],"factors":[42],"(HGFs)":[43],"are":[44],"among":[45],"newer":[47],"approved":[51],"commercialized":[53],"different":[58,152,169],"types":[59],"The":[62],"HGFs":[63,133],"including":[64],"erythropoietin":[65],"(EPO),":[66],"granulocyte":[67,72],"macrophage":[68,76],"colony-stimulating":[69,73,77],"factor":[70,74,78],"(GMCSF),":[71],"(GCSF),":[75],"(MCSF),":[79],"thrombopoietin":[80],"(TPO)":[81],"interleukin-3":[83],"(IL-3)":[84],"been":[86,116],"known":[87],"over":[89],"25":[90],"years,":[91],"named":[92],"their":[94],"role":[95],"proliferation,":[98],"differentiation":[99],"survival":[101],"hematopoietic":[103],"progenitor":[104],"cells.":[105],"Especially,":[106],"forms":[109,175],"EPO,":[111],"GMCSF":[112],"GCSF":[114],"used":[117],"years":[120],"clinical":[122],"practice":[123],"oncological":[125],"hematological":[127],"pathology.":[128],"Recent":[129],"studies":[130],"suggest":[131],"also":[135,160],"non-hematopoietic":[137],"functions":[138,154],"brain,":[141],"heart,":[142],"kidney":[143],"organs.":[146],"This":[147],"review":[148],"briefly":[149],"summarizes":[150],"physiological":[153],"major":[157],"HGFs.":[158,180],"It":[159],"provides":[161],"a":[162],"critical":[163],"comprehensive":[165],"overview":[166],"therapeutic":[170],"applications":[171],"some":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}