{"id":"https://openalex.org/W2185438359","doi":null,"title":"Otoacoustic emissions analysers for monitoring aminoglycosides ototoxicity.","display_name":"Otoacoustic emissions analysers for monitoring aminoglycosides ototoxicity.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2185438359","mag":"2185438359","pmid":"https://pubmed.ncbi.nlm.nih.gov/20446443"},"language":"en","primary_location":{"id":"pmid:20446443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20446443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of internal medicine = Revue roumaine de medecine interne","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025035737","display_name":"Ruxandra Moroti Constantinescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruxandra Moroti Constantinescu","raw_affiliation_strings":["Matei Bal\u015f National Institute for Infectious Diseases, Bucharest, Romania. ruxandra_moroti@yahoo.com","Matei Bal\u015f National Institute for Infectious Diseases, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matei Bal\u015f National Institute for Infectious Diseases, Bucharest, Romania. ruxandra_moroti@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Matei Bal\u015f National Institute for Infectious Diseases, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081661125","display_name":"Madalina Gabriela Georgescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u0103d\u0103lina Georgescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Pascu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pascu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072431506","display_name":"Adriana Hristea","orcid":"https://orcid.org/0000-0002-6505-1699","observed_orcids":["https://orcid.org/0000-0002-6505-1699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana Hristea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111379628","display_name":"Victoria Aram\u0103","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Aram\u0103","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015911274","display_name":"Cristian B\u0103icu\u015f","orcid":"https://orcid.org/0000-0002-7954-0098","observed_orcids":["https://orcid.org/0000-0002-7954-0098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C B\u0103icu\u015f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007756311","display_name":"Ruxandra C\u00e2lin","orcid":"https://orcid.org/0000-0001-6516-9825","observed_orcids":["https://orcid.org/0000-0001-6516-9825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruxandra Oana C\u0103lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Eugenia Kovacs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugenia Kovacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"47","issue":"3","first_page":"273","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoglycoside-ototoxicity","display_name":"aminoglycoside ototoxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/otoacoustic-emissions","display_name":"otoacoustic emissions","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hearing-loss-monitoring","display_name":"hearing loss monitoring","score":0.722000002861023},{"id":"https://openalex.org/keywords/high-frequency-hearing-loss","display_name":"high-frequency hearing loss","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.9314054250717163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7489020228385925},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.733106255531311},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5620403289794922},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5465438961982727},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.5283589959144592},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5151799917221069},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.4731786549091339},{"id":"https://openalex.org/C2780941679","wikidata":"https://www.wikidata.org/wiki/Q912019","display_name":"Otoacoustic emission","level":3,"score":0.4335891306400299},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.4196937084197998},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.4128107726573944},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.33657121658325195},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29236459732055664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2254161238670349},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.17715707421302795},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017084","descriptor_name":"Otoacoustic Emissions, Spontaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20446443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20446443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of internal medicine = Revue roumaine de medecine interne","raw_type":"Journal Article"},{"id":"mag:2185438359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20446443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1908839387","https://openalex.org/W1991289698","https://openalex.org/W2047770131","https://openalex.org/W2054187553","https://openalex.org/W2073696812","https://openalex.org/W2090785276","https://openalex.org/W2097950833","https://openalex.org/W2112756982","https://openalex.org/W2157614840","https://openalex.org/W2163290033","https://openalex.org/W2169765696","https://openalex.org/W2410233975"],"related_works":["https://openalex.org/W2012077160","https://openalex.org/W2010036821","https://openalex.org/W1983128175","https://openalex.org/W2945247008","https://openalex.org/W2125458392","https://openalex.org/W2033015375","https://openalex.org/W2891831923","https://openalex.org/W2058650983","https://openalex.org/W2001368307","https://openalex.org/W2008254668"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Aminoglycosides":[1],"(AG)":[2],"are":[3],"widely":[4],"prescribed":[5],"despite":[6],"their":[7],"notorious":[8],"toxicity.":[9],"These":[10],"antibiotics":[11],"cause":[12],"irreversible":[13],"hearing":[14,271,303],"loss,":[15],"starting":[16],"with":[17,96,219,241,278],"high":[18,226],"frequencies":[19,24,227],"and":[20,64,113,130,146,194,208,259,294,323],"progressing":[21],"toward":[22],"conversational":[23,309],"(0.5-2":[25],"kHz),":[26],"by":[27,45],"destroying":[28],"the":[29,34,58,67,71,109,115,127,134,138,211,215,242,255,260,270,308,316],"acoustic":[30,68,238,296],"hair":[31],"cells":[32,41],"in":[33,204,214,231,276],"inner":[35],"ear.":[36],"The":[37,55,122,140,237,311],"integrity":[38],"of":[39,57,70,83,117,137,178,222,234,244,257,265,284,307],"these":[40],"could":[42,300],"be":[43],"analysed":[44],"recording":[46],"faint":[47],"sounds":[48],"that":[49,228],"they":[50],"produce":[51],"otoacoustic":[52],"emissions":[53],"(OAE).":[54],"aim":[56],"present":[59],"study":[60,82],"was":[61,159,202,273],"to":[62,65,315,325],"monitor":[63],"characterise":[66],"toxicity":[69],"AG":[72,285],"using":[73,161],"an":[74,97,150],"OAE":[75,94,282],"analyser.":[76],"METHOD:":[77],"We":[78,91,153,170,247],"performed":[79,125],"a":[80,220,251,288],"prospective":[81],"49":[84,172],"patients":[85,155,173,193,206],"receiving":[86],"gentamicin":[87],"(G),":[88],"during":[89,111,210],"2007-2008.":[90],"made":[92],"serial":[93],"recordings":[95,123],"ILO":[98],"92":[99],"analyser":[100],"(1-8":[101],"kHz)":[102],"on":[103],"at":[104,108,126],"least":[105],"3":[106,217],"occasions:":[107],"start,":[110],"treatment":[112,286],"after":[114],"cessation":[116],"G":[118,185,245],"therapy":[119,212],"(1-6":[120],"months).":[121],"were":[124],"patient's":[128],"bedside":[129],"did":[131,248],"not":[132,148,249],"require":[133],"active":[135],"participation":[136],"patient.":[139],"method":[141],"is":[142,287,313,321],"fast,":[143],"non-invasive,":[144],"accurate":[145],"does":[147],"request":[149],"ENT":[151],"specialist.":[152],"included":[154],"presenting":[156],"OAE.":[157],"Ototoxicity":[158],"defined":[160],"adapted":[162],"ASHA":[163],"(American":[164],"Speech":[165],"Hearing":[166,200],"Association)":[167],"criteria.":[168],"RESULTS:":[169],"studied":[171],"(24/25":[174],"female/male),":[175],"mean":[176],"age":[177],"37.24":[179],"(3-70":[180],"years":[181],"old),":[182],"who":[183],"received":[184],"for":[186,292],"4-42":[187],"days:":[188],"less":[189],"than":[190,196],"10":[191,197,205,235],"days--24":[192],"more":[195],"days--25":[198],"patients.":[199],"impairment":[201,258],"observed":[203],"(20.4%)":[207],"appeared":[209],"or":[213,224,263],"next":[216],"months,":[218],"loss":[221,272,304],"one":[223],"2":[225],"occurred":[229],"unilaterally":[230],"9":[232],"out":[233],"cases.":[236],"damage":[239,306],"correlates":[240],"length":[243],"treatment.":[246],"find":[250],"statistical":[252],"correlation":[253],"between":[254],"degree":[256],"age,":[261],"regimen":[262],"addition":[264],"another":[266],"ototoxic":[267],"drug,":[268],"although":[269],"slightly":[274],"higher":[275],"those":[277],"concomitant":[279],"exposure.":[280],"CONCLUSION:":[281],"monitoring":[283],"very":[289],"useful":[290],"way":[291],"detecting":[293],"preventing":[295],"toxicity,":[297],"because":[298],"it":[299,320],"warn":[301],"about":[302],"before":[305],"frequencies.":[310],"accuracy":[312],"similar":[314],"classical":[317],"methods,":[318],"but":[319],"faster":[322],"easier":[324],"perform.":[326]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}