{"id":"https://openalex.org/W2185315324","doi":null,"title":"Approach of Fixed Dose Combination in Formulation and Development of Dispersible Tablets for Migraine Therapy","display_name":"Approach of Fixed Dose Combination in Formulation and Development of Dispersible Tablets for Migraine Therapy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2185315324","mag":"2185315324"},"language":"en","primary_location":{"id":"mag:2185315324","doi":null,"is_oa":false,"landing_page_url":"http://ijpi.org/wp-content/uploads/sep2013/5.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111885869","display_name":"CHINMAY ANAND","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHINMAY ANAND","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034771235","display_name":"Gali Vidyasagar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Vidyasagar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.996999979019165},{"id":"https://openalex.org/keywords/dispersible-tablets","display_name":"dispersible tablets","score":0.9359999895095825},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tolfenamic-acid","display_name":"tolfenamic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":1.0},{"id":"https://openalex.org/keywords/disintegrants","display_name":"disintegrants","score":0.9869999885559082},{"id":"https://openalex.org/keywords/taste-masking","display_name":"taste masking","score":0.9670000076293945},{"id":"https://openalex.org/keywords/polymer-coatings","display_name":"polymer coatings","score":0.9509999752044678},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/solubility-enhancement","display_name":"solubility enhancement","score":0.8140000104904175},{"id":"https://openalex.org/keywords/analgesic-formulation","display_name":"analgesic formulation","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C86178769","wikidata":"https://www.wikidata.org/wiki/Q1130789","display_name":"Micronization","level":3,"score":0.5896918773651123},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.5857168436050415},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.5783870220184326},{"id":"https://openalex.org/C2776623344","wikidata":"https://www.wikidata.org/wiki/Q5456317","display_name":"Fixed-dose combination","level":2,"score":0.564111590385437},{"id":"https://openalex.org/C2779252780","wikidata":"https://www.wikidata.org/wiki/Q582687","display_name":"Antipyretic","level":3,"score":0.5613721609115601},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4961441457271576},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.4358757436275482},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.43343690037727356},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4108608365058899},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40312162041664124},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3746342957019806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3512265682220459},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33582037687301636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.318040668964386},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31752732396125793},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12422233819961548},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.09016594290733337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185315324","doi":null,"is_oa":false,"landing_page_url":"http://ijpi.org/wp-content/uploads/sep2013/5.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1514223003","https://openalex.org/W1515459678","https://openalex.org/W1566408227","https://openalex.org/W2040656207","https://openalex.org/W2057408169","https://openalex.org/W2078814811","https://openalex.org/W2094590592","https://openalex.org/W2099236418","https://openalex.org/W2125350651","https://openalex.org/W2136921249","https://openalex.org/W2152240524","https://openalex.org/W2159269801","https://openalex.org/W2166473230","https://openalex.org/W2166808901"],"related_works":["https://openalex.org/W2212294904","https://openalex.org/W1972241691","https://openalex.org/W2094590592","https://openalex.org/W7214445672","https://openalex.org/W2112533118","https://openalex.org/W2027495164","https://openalex.org/W7127330267","https://openalex.org/W4405961819","https://openalex.org/W3082032796","https://openalex.org/W2416925008"],"abstract_inverted_index":{"Concept":[0],"of":[1,10,33,49,84,91,107,121,133,137,149],"fixed":[2,25],"dose":[3,26],"combination":[4,27],"can":[5],"be":[6],"defined":[7],"as":[8],"formulation":[9,111,148],"two":[11],"or":[12],"more":[13],"active":[14],"ingredients":[15],"formulated":[16],"in":[17,30],"a":[18,58,81,104,130],"single":[19],"dosage":[20],"form.":[21],"There":[22],"are":[23,28],"server":[24],"available":[29],"the":[31,47],"treatment":[32],"migraine":[34],"but":[35],"having":[36],"its":[37],"own":[38],"limitations.":[39],"Tolfenamic":[40,85],"acid":[41],"(TA)":[42],"is":[43,57],"used":[44,60,146],"to":[45,79],"treat":[46],"symptoms":[48],"migraine.":[50],"Paracetamol":[51],"(4'-hydroxyacetanilide,":[52],"N-acetyl":[53],"paminophenol,":[54],"acetaminophen,":[55],"PAR)":[56],"widely":[59],"over-the-counter":[61],"analgesic":[62],"and":[63,70,87,118,135,143],"antipyretic":[64],"drug":[65],"without":[66],"any":[67],"gastric":[68],"irritation":[69],"ulcerative":[71],"effects.":[72],"The":[73,110],"current":[74],"research":[75],"work":[76],"was":[77,112,129],"set":[78],"formulate":[80],"dispersible":[82,122],"Tablets":[83],"Acid":[86],"Paracetamol.":[88],"Various":[89],"formulations":[90],"FDCs":[92],"were":[93],"manufactured":[94],"by":[95,102,140],"using":[96],"different":[97],"disintegrants":[98],"than":[99,113],"taste":[100],"masked":[101],"applying":[103],"thin":[105],"layer":[106],"polymer":[108],"coating.":[109],"evaluated":[114],"for":[115],"various":[116],"physical":[117],"analytical":[119],"properties":[120],"tablets.":[123],"Results":[124],"obtained":[125],"showed":[126],"that":[127],"there":[128],"significant":[131],"impact":[132],"disintegrants,":[134],"application":[136],"solubility":[138],"enhancement":[139],"solid":[141],"dispersion":[142],"co":[144],"micronization":[145],"during":[147],"FDCs.":[150]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}