{"id":"https://openalex.org/W2185285396","doi":null,"title":"Activation of Innate Immunity Regression through an HMGB1-Mediated DNA Alkylating Therapy Induces Tumor","display_name":"Activation of Innate Immunity Regression through an HMGB1-Mediated DNA Alkylating Therapy Induces Tumor","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2185285396","mag":"2185285396"},"language":"en","primary_location":{"id":"mag:2185285396","doi":null,"is_oa":false,"landing_page_url":"https://www.mgm.stonybrook.edu/zong/pdf/15.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Colin L. Crawford","orcid":"https://orcid.org/0000-0001-7154-5698","observed_orcids":["https://orcid.org/0000-0001-7154-5698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin L. Crawford","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7154-5698","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091798101","display_name":"Wei\u2010Xing Zong","orcid":"https://orcid.org/0000-0002-3129-8220","observed_orcids":["https://orcid.org/0000-0002-3129-8220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei\u2010Xing Zong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3129-8220","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055114112","display_name":"Gregory J. Sabino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory J. Sabino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111886652","display_name":"Martha B. Furie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martha B. Furie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039857347","display_name":"Richard R. Kew","orcid":"https://orcid.org/0000-0002-4482-7179","observed_orcids":["https://orcid.org/0000-0002-4482-7179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard R. Kew","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4482-7179","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017046089","display_name":"Luana Guerriero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luana Guerriero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073794395","display_name":"Dara Ditsworth","orcid":"https://orcid.org/0000-0002-1086-9426","observed_orcids":["https://orcid.org/0000-0002-1086-9426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dara Ditsworth","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1086-9426","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048543554","display_name":"Joseph M. Catanzaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph M. Catanzaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16962547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6899999976158142},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5170000195503235},{"id":"https://openalex.org/keywords/chemoresistance-reversal","display_name":"chemoresistance reversal","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7688230276107788},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5962827801704407},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5462401509284973},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44529300928115845},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44252216815948486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37464189529418945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32090550661087036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23670485615730286},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2300964593887329}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185285396","doi":null,"is_oa":false,"landing_page_url":"https://www.mgm.stonybrook.edu/zong/pdf/15.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W398325","https://openalex.org/W294896987","https://openalex.org/W1595815978","https://openalex.org/W1655415402","https://openalex.org/W1845459216","https://openalex.org/W1921745771","https://openalex.org/W1942388905","https://openalex.org/W1945598588","https://openalex.org/W1965037168","https://openalex.org/W1969305254","https://openalex.org/W1972442585","https://openalex.org/W1985271970","https://openalex.org/W1987224284","https://openalex.org/W1991825448","https://openalex.org/W2004266769","https://openalex.org/W2004273407","https://openalex.org/W2005749687","https://openalex.org/W2016000295","https://openalex.org/W2018653121","https://openalex.org/W2019412595","https://openalex.org/W2025110778","https://openalex.org/W2038781914","https://openalex.org/W2040898123","https://openalex.org/W2047022250","https://openalex.org/W2047902191","https://openalex.org/W2049856484","https://openalex.org/W2052094075","https://openalex.org/W2058648826","https://openalex.org/W2064104050","https://openalex.org/W2080208339","https://openalex.org/W2083080666","https://openalex.org/W2084623259","https://openalex.org/W2093424661","https://openalex.org/W2099325042","https://openalex.org/W2104061060","https://openalex.org/W2106917466","https://openalex.org/W2106949373","https://openalex.org/W2108767527","https://openalex.org/W2109590683","https://openalex.org/W2115293825","https://openalex.org/W2116126240","https://openalex.org/W2120909020","https://openalex.org/W2131523916","https://openalex.org/W2133000461","https://openalex.org/W2133669258","https://openalex.org/W2141778744","https://openalex.org/W2142730895","https://openalex.org/W2147426561","https://openalex.org/W2153917851","https://openalex.org/W2159882838","https://openalex.org/W2160369507","https://openalex.org/W2164714222","https://openalex.org/W2165372425","https://openalex.org/W2166601968","https://openalex.org/W2171028311"],"related_works":["https://openalex.org/W1486665165","https://openalex.org/W2126526380","https://openalex.org/W2767753260","https://openalex.org/W2019773562","https://openalex.org/W2377138717","https://openalex.org/W4403256704","https://openalex.org/W7098620745","https://openalex.org/W2093424661","https://openalex.org/W2018905044","https://openalex.org/W2051032415"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}