{"id":"https://openalex.org/W2185283754","doi":null,"title":"Genetic determinants of serum prostate-specific antigen levels in healthy men from a multiethnic cohort.","display_name":"Genetic determinants of serum prostate-specific antigen levels in healthy men from a multiethnic cohort.","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W2185283754","mag":"2185283754","pmid":"https://pubmed.ncbi.nlm.nih.gov/11401905"},"language":"en","primary_location":{"id":"pmid:11401905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11401905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020139155","display_name":"Wenmei Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W M Xue","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038379283","display_name":"Gerhard A. Coetzee","orcid":"https://orcid.org/0000-0001-8820-8364","observed_orcids":["https://orcid.org/0000-0001-8820-8364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G A Coetzee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150041","display_name":"Ronald K. Ross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K Ross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026527537","display_name":"Ryan A. Irvine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Irvine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060925344","display_name":"Laurence K. Kolonel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Kolonel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111890042","display_name":"Brian E. Henderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B E Henderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074503361","display_name":"Sue A. Ingles","orcid":"https://orcid.org/0000-0001-9181-8745","observed_orcids":["https://orcid.org/0000-0001-9181-8745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Ingles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8095,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.84798279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"6","first_page":"575","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.9549999833106995},{"id":"https://openalex.org/keywords/serum-psa-levels","display_name":"serum PSA levels","score":0.8550000190734863},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8190000057220459},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.6840000152587891},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.8759999871253967},{"id":"https://openalex.org/keywords/prostate-cancer-risk","display_name":"prostate cancer risk","score":0.8180000185966492},{"id":"https://openalex.org/keywords/multiethnic-cohort","display_name":"multi-ethnic cohort","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8189276456832886},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6346613764762878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5820841789245605},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5587079524993896},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4812428951263428},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4567774832248688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.437987357378006},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4275902211666107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35785675048828125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2584190368652344},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.180060476064682},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17041239142417908}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11401905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11401905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"mag:2185283754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11401905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4344742353","display_name":"MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER","funder_award_id":"R01CA054281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5257767066","display_name":"RISK FACTORS FOR ADVANCED PROSTATE CANCER","funder_award_id":"R01CA084979","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6863728073","display_name":"ANDROGEN RECEPTOR AND PROSTATE CANCER RISK IN CHINESE","funder_award_id":"R01CA084890","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1517827056","https://openalex.org/W1555159013","https://openalex.org/W1998476721","https://openalex.org/W2023396505","https://openalex.org/W2027066393","https://openalex.org/W2031314819","https://openalex.org/W2032432671","https://openalex.org/W2032548256","https://openalex.org/W2101065984","https://openalex.org/W2111051549","https://openalex.org/W2130538948","https://openalex.org/W2139366934","https://openalex.org/W2161103103","https://openalex.org/W2282666177","https://openalex.org/W2319972791"],"related_works":["https://openalex.org/W7100241783","https://openalex.org/W1910491382","https://openalex.org/W2099778808","https://openalex.org/W2162758968","https://openalex.org/W7097470365","https://openalex.org/W2089350191","https://openalex.org/W2107790140","https://openalex.org/W2102621990","https://openalex.org/W2156812459","https://openalex.org/W2096368473"],"abstract_inverted_index":{"We":[0],"recently":[1],"reported":[2],"an":[3],"association":[4],"between":[5,131],"prostate":[6],"cancer":[7],"risk":[8],"and":[9,16,35,47,61,74,135,209,225],"polymorphisms":[10],"in":[11,42,201,206,215],"the":[12,48,68,113,121,150,207,221],"prostate-specific":[13],"antigen":[14],"(PSA)":[15],"androgen":[17],"receptor":[18],"(AR)":[19],"genes.":[20],"The":[21,129],"purpose":[22],"of":[23,70,171,189],"this":[24],"study":[25],"is":[26],"to":[27,66,141,213],"test":[28],"whether":[29],"these":[30],"two":[31,49],"polymorphisms,":[32],"AR":[33,71,90,136,210,227],"CAG":[34,72,91,137,173,191,228],"PSA":[36,40,46,75,80,84,98,103,107,114,133,142,165,183,208,217,222,235],"ARE1,":[37],"influence":[38],"serum":[39,79,83,132,164,182,216,234],"levels":[41,108],"healthy":[43,55,202],"men.":[44],"Serum":[45,97],"genotypes":[50,125],"were":[51,64],"assayed":[52],"for":[53,147,161,179],"420":[54],"men":[56,111,119],"from":[57,156],"a":[58],"multiethnic":[59],"cohort,":[60],"regression":[62],"models":[63],"fit":[65],"estimate":[67],"effects":[69],"genotype":[73,77,116,143,148,162,180,224],"ARE1":[76,104],"on":[78,231],"levels.":[81,218,236],"Predicted":[82],"decreased":[85],"3.5%":[86],"with":[87,102,106,112,118,120,168,186,220],"each":[88,169,187],"additional":[89],"repeat":[92,174,192],"decile":[93,175,193],"(P":[94,126,144,158,176,194],"=":[95,127,145,159,177,195],"0.01).":[96],"was":[99,152],"also":[100],"associated":[101],"genotype,":[105],"higher":[109,233],"among":[110],"AA":[115,223],"compared":[117],"AG":[122],"or":[123],"GG":[124],"0.02).":[128,196],"relationship":[130],"level":[134],"length":[138],"differed":[139],"according":[140],"0.049):":[146],"GG,":[149],"slope":[151],"not":[153],"significantly":[154],"different":[155],"zero":[157],"0.74);":[160],"AG,":[163],"increased":[166,184],"4.5%":[167],"decrease":[170,188],"one":[172,190],"0.03);":[178],"AA,":[181],"7%":[185],"These":[197],"results":[198],"indicate":[199],"that":[200],"men,":[203],"genetic":[204],"variants":[205],"genes":[211],"contribute":[212],"variation":[214],"Men":[219],"short":[226],"alleles":[229],"have,":[230],"average,":[232]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
