{"id":"https://openalex.org/W2185266239","doi":null,"title":"Anxiolytic- and antidepressant-like effects of 7-OH-DPAT, preferential dopamine D3 receptor agonist, in rats.","display_name":"Anxiolytic- and antidepressant-like effects of 7-OH-DPAT, preferential dopamine D3 receptor agonist, in rats.","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2185266239","mag":"2185266239","pmid":"https://pubmed.ncbi.nlm.nih.gov/15591639"},"language":"en","primary_location":{"id":"pmid:15591639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15591639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035122641","display_name":"Zofia Rog\u00f3\u017c","orcid":"https://orcid.org/0000-0002-8538-3594","observed_orcids":["https://orcid.org/0000-0002-8538-3594"]},"institutions":[{"id":"https://openalex.org/I4210120768","display_name":"Maj Institute of Pharmacology","ror":"https://ror.org/0288swk05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Z Rog\u00f3z","raw_affiliation_strings":["Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Krak\u00f3w, Poland. rogoz@if-pan.krakow.pl","Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Sm\u00eatna 12, PL 31-343 Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Krak\u00f3w, Poland. rogoz@if-pan.krakow.pl","institution_ids":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Sm\u00eatna 12, PL 31-343 Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109368216","display_name":"Gra\u017cyna Skuza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Skuza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005161790","display_name":"A K\u0142lodzi\u0144ska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A K\u0142lodzi\u0144ska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5428,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.54200345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"56","issue":"5","first_page":"519","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/7-oh-dpat","display_name":"7-OH-DPAT","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dopamine-d3-receptor-agonist","display_name":"dopamine D3 receptor agonist","score":0.9549999833106995},{"id":"https://openalex.org/keywords/anxiolytic-like-effects","display_name":"anxiolytic-like effects","score":0.8500000238418579},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":1.0},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7009999752044678},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9980000257492065},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.8339999914169312},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9950000047683716},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9430000185966492},{"id":"https://openalex.org/keywords/drug-potentiation","display_name":"drug potentiation","score":0.597000002861023},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.8401126265525818},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.7380173802375793},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.6656754612922668},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6649910807609558},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6294147372245789},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6264089941978455},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5820461511611938},{"id":"https://openalex.org/C2776238416","wikidata":"https://www.wikidata.org/wiki/Q4644282","display_name":"8-OH-DPAT","level":5,"score":0.4977453052997589},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.4500456750392914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4358668327331543},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.42044320702552795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3923366069793701},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35427314043045044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3359946012496948},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.29615843296051025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2822420001029968},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2518739104270935},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.19589975476264954},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.04212954640388489},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013764","descriptor_name":"Tetrahydronaphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15591639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15591639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.377.7825","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.377.7825","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.if-pan.krakow.pl/pjp/pdf/2004/5_519.pdf","raw_type":"text"},{"id":"mag:2185266239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15591639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W104154165","https://openalex.org/W337748870","https://openalex.org/W1960639209","https://openalex.org/W1966092598","https://openalex.org/W1969107429","https://openalex.org/W1969484863","https://openalex.org/W1973386992","https://openalex.org/W1974116281","https://openalex.org/W1974595085","https://openalex.org/W1985582613","https://openalex.org/W1989850259","https://openalex.org/W1993971504","https://openalex.org/W2002421744","https://openalex.org/W2003085108","https://openalex.org/W2003261003","https://openalex.org/W2006240551","https://openalex.org/W2006566873","https://openalex.org/W2012353464","https://openalex.org/W2015025334","https://openalex.org/W2028936866","https://openalex.org/W2033146497","https://openalex.org/W2033284293","https://openalex.org/W2035089291","https://openalex.org/W2036218676","https://openalex.org/W2041780263","https://openalex.org/W2042491822","https://openalex.org/W2043107955","https://openalex.org/W2046100639","https://openalex.org/W2048149415","https://openalex.org/W2048937194","https://openalex.org/W2064893949","https://openalex.org/W2068993244","https://openalex.org/W2074773874","https://openalex.org/W2075385428","https://openalex.org/W2079322728","https://openalex.org/W2089734727","https://openalex.org/W2090535731","https://openalex.org/W2092953670","https://openalex.org/W2141167502","https://openalex.org/W2167487498","https://openalex.org/W2312417601","https://openalex.org/W2397444180","https://openalex.org/W2401446701","https://openalex.org/W2405264409","https://openalex.org/W2413611497"],"related_works":["https://openalex.org/W337748870","https://openalex.org/W2290954425","https://openalex.org/W2003261003","https://openalex.org/W2396244615","https://openalex.org/W4249442055","https://openalex.org/W1969484863","https://openalex.org/W2101290162","https://openalex.org/W2056967782","https://openalex.org/W2033017106","https://openalex.org/W2405264409"],"abstract_inverted_index":{"The":[0,47,60,70],"aim":[1],"of":[2,15,50,105,147,178,195,208],"the":[3,56,66,88,99,103,128,155,165,175,193,206],"present":[4],"study":[5],"was":[6,53,63,162],"to":[7,204],"examine":[8],"a":[9,19,29,139,190],"potential":[10],"anxiolytic-":[11],"and":[12,25,79,95,136],"antidepressant-like":[13,61,121,176],"action":[14],"(+)-7-hydroxy-2-(di-n-propylamino)tetralin":[16],"hydrobromide":[17],"(7-OH-DPAT),":[18],"preferential":[20,184],"dopamine":[21,31],"D(3)":[22,32,185],"receptor":[23,33,186],"agonist,":[24,34],"N-{4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl}-2-naphthylcarboxamide":[26],"(BP":[27],"897),":[28],"partial":[30],"in":[35,55,87,102,127,142,164,192],"male":[36],"Wistar":[37],"rats.":[38],"Diazepam":[39],"or":[40],"imipramine":[41,137],"were":[42],"used":[43],"as":[44],"reference":[45],"compounds.":[46],"anxiolytic-like":[48,85,106],"effect":[49,62,141,177],"those":[51],"drugs":[52],"tested":[54,97],"elevated":[57,89],"plus-maze":[58,90],"test.":[59,69,91,131],"estimated":[64],"using":[65],"forced":[67,129,166],"swimming":[68,130,167],"obtained":[71],"results":[72],"showed":[73,120],"that":[74,183],"7-OH-DPAT":[75,114,135],"at":[76,98,115],"low":[77],"doses":[78,100],"BP":[80,93,160],"897":[81,94,161],"(like":[82],"diazepam)":[83],"induced":[84,138],"effects":[86],"7-OH-DPAT,":[92],"diazepam,":[96],"effective":[101],"model":[104],"actions,":[107],"did":[108,152],"not":[109,153],"affect":[110],"motor":[111],"coordination.":[112],"Moreover,":[113],"higher":[116],"doses,":[117],"like":[118],"imipramine,":[119],"effect,":[122],"significantly":[123],"reducing":[124],"immobility":[125],"time":[126],"Combined":[132],"treatment":[133],"with":[134],"stronger":[140],"Porsolt's":[143],"test":[144,168],"than":[145],"administration":[146],"either":[148],"drug":[149],"alone,":[150],"but":[151,172],"increase":[154],"locomotor":[156],"activity.":[157],"In":[158],"contrast,":[159],"inactive":[163],"when":[169],"given":[170],"alone":[171],"it":[173],"potentiated":[174],"imipramine.":[179],"These":[180],"data":[181],"suggest":[182],"agonists":[187],"may":[188],"play":[189],"role":[191],"therapy":[194],"anxiety":[196],"and/or":[197],"depression,":[198],"however,":[199],"further":[200],"studies":[201],"are":[202],"necessary":[203],"elucidate":[205],"mechanism":[207],"these":[209],"actions.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}