{"id":"https://openalex.org/W2185217807","doi":null,"title":"The FXIII Val34Leu polymorphism in venous and arterial thromboembolism.","display_name":"The FXIII Val34Leu polymorphism in venous and arterial thromboembolism.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2185217807","mag":"2185217807","pmid":"https://pubmed.ncbi.nlm.nih.gov/10702819"},"language":"en","primary_location":{"id":"pmid:10702819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10702819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000211435","display_name":"Javier Corral","orcid":"https://orcid.org/0000-0003-0288-1107","observed_orcids":["https://orcid.org/0000-0003-0288-1107"]},"institutions":[{"id":"https://openalex.org/I4210115362","display_name":"Centro Regional de Hemodonaci\u00f3n","ror":"https://ror.org/02a57s352","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210115362"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J Corral","raw_affiliation_strings":["Hematology and Clinical Oncology, Hospital General Universitario, Centro Regional de Hemodonaci\u00f3n, Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Clinical Oncology, Hospital General Universitario, Centro Regional de Hemodonaci\u00f3n, Murcia, Spain","institution_ids":["https://openalex.org/I4210115362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064868294","display_name":"Roc\u00edo G\u00f3nz\u00e1lez\u2010Conejero","orcid":"https://orcid.org/0000-0002-4772-9822","observed_orcids":["https://orcid.org/0000-0002-4772-9822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Gonz\u00e1lez-Conejero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112058858","display_name":"Juan Antonio Iniesta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Iniesta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047936186","display_name":"Jos\u00e9 Rivera","orcid":"https://orcid.org/0000-0003-4225-6840","observed_orcids":["https://orcid.org/0000-0003-4225-6840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Rivera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000429090","display_name":"Constantino Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0002-2976-2354","observed_orcids":["https://orcid.org/0000-0002-2976-2354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mart\u00ednez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033392955","display_name":"Vicente Vicente","orcid":"https://orcid.org/0000-0002-4278-3264","observed_orcids":["https://orcid.org/0000-0002-4278-3264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Vicente","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6091,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.95491697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"85","issue":"3","first_page":"293","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.18870000541210175,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-xiii","display_name":"factor XIII","score":0.7760000228881836},{"id":"https://openalex.org/keywords/val34leu-polymorphism","display_name":"Val34Leu polymorphism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9229999780654907},{"id":"https://openalex.org/keywords/arterial-thromboembolism","display_name":"arterial thromboembolism","score":0.9100000262260437},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.7630000114440918},{"id":"https://openalex.org/keywords/prothrombotic-factors","display_name":"prothrombotic factors","score":0.828000009059906},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5889999866485596},{"id":"https://openalex.org/keywords/spanish-population","display_name":"Spanish population","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7273637056350708},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.636939287185669},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5730947256088257},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5715676546096802},{"id":"https://openalex.org/C2779672106","wikidata":"https://www.wikidata.org/wiki/Q423712","display_name":"Factor XIII","level":3,"score":0.5631356239318848},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5451256036758423},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5156046748161316},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4951914846897125},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.4670400023460388},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4637409448623657},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45635417103767395},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.42861196398735046},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4199434220790863},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35531753301620483},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18577030301094055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1805192530155182},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.14104044437408447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09909573197364807},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10702819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10702819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3614144f625e416ba549d0c700ffa3db","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3614144f625e416ba549d0c700ffa3db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 85, Iss 3 (2000)","raw_type":"article"},{"id":"mag:2185217807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10702819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W33124927","https://openalex.org/W1594237533","https://openalex.org/W1825093578","https://openalex.org/W1975220725","https://openalex.org/W1990502944","https://openalex.org/W1993916708","https://openalex.org/W2015093314","https://openalex.org/W2019743809","https://openalex.org/W2061249415","https://openalex.org/W2097289395","https://openalex.org/W2130036963","https://openalex.org/W2137365180","https://openalex.org/W2144634347","https://openalex.org/W2220542540","https://openalex.org/W2284175756","https://openalex.org/W2285840630","https://openalex.org/W2330126172","https://openalex.org/W2400428232","https://openalex.org/W2401950536","https://openalex.org/W2407491529","https://openalex.org/W2414248457","https://openalex.org/W2416459134","https://openalex.org/W2916158257"],"related_works":["https://openalex.org/W2052306661","https://openalex.org/W2332360150","https://openalex.org/W2084345726","https://openalex.org/W1529952402","https://openalex.org/W2899161135","https://openalex.org/W2021210269","https://openalex.org/W2184661661","https://openalex.org/W2122898260","https://openalex.org/W1998773256","https://openalex.org/W2097289395"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,76,131],"OBJECTIVE:":[2],"Several":[3],"hereditary":[4],"disorders":[5,70],"affecting":[6],"coagulation":[7],"factors":[8],"have":[9],"been":[10,34],"identified":[11,35],"as":[12,36,98],"prothrombotic":[13],"risk":[14],"factors.":[15],"Recently,":[16],"the":[17,22,60,80,93,120,144,150],"common":[18],"Val34Leu":[19],"polymorphism":[20,64,84],"of":[21,54,62,82,89,95,122,146],"A-chain":[23],"factor":[24,30,40],"XIII":[25,31],"gene,":[26],"associated":[27],"with":[28],"high":[29],"activity,":[32],"has":[33],"a":[37,72],"protective":[38],"genetic":[39],"against":[41],"occlusive":[42],"arterial":[43,66],"and":[44,49,67,108,128],"venous":[45,68,110],"diseases":[46],"in":[47,65,71,85,119,143,149],"British":[48],"Finnish":[50],"populations.":[51],"The":[52,133],"aim":[53],"our":[55],"study":[56],"was":[57],"to":[58],"investigate":[59],"role":[61,142],"this":[63,83],"thromboembolic":[69,147],"distinct":[73],"population.":[74,152],"DESIGN":[75],"METHODS:":[77],"We":[78],"analyzed":[79],"prevalence":[81,121],"three":[86],"case/control":[87],"studies":[88],"consecutive":[90],"patients":[91,127],"from":[92],"south":[94],"Spain":[96],"diagnosed":[97],"having":[99],"acute":[100,104],"coronary":[101],"syndromes":[102],"(101),":[103],"cerebrovascular":[105],"events":[106],"(104),":[107],"deep":[109],"thrombosis":[111],"(97).":[112],"RESULTS:":[113],"No":[114],"significant":[115],"differences":[116],"were":[117],"detected":[118],"genotypes":[123],"or":[124],"alleles":[125],"between":[126],"controls.":[129],"INTERPRETATION":[130],"CONCLUSIONS:":[132],"Leu":[134],"34":[135],"allele":[136],"does":[137],"not":[138],"play":[139],"an":[140],"important":[141],"development":[145],"episodes":[148],"Spanish":[151]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
