{"id":"https://openalex.org/W2185092016","doi":null,"title":"Basi neurobiologiche e farmacologiche di una innovativa terapia antidepressiva Neurobiology and pharmacology of a new antidepressant therapy","display_name":"Basi neurobiologiche e farmacologiche di una innovativa terapia antidepressiva Neurobiology and pharmacology of a new antidepressant therapy","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2185092016","mag":"2185092016"},"language":"it","primary_location":{"id":"mag:2185092016","doi":null,"is_oa":false,"landing_page_url":"http://www.jpsychopathol.it/issues/2011/vol17-3/10Biggio.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090509427","display_name":"Giovanni Biggio","orcid":"https://orcid.org/0000-0003-2333-5535","observed_orcids":["https://orcid.org/0000-0003-2333-5535"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giovanni Biggio","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2333-5535","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090509427"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17581631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agomelatine","display_name":"agomelatine","score":1.0},{"id":"https://openalex.org/keywords/antidepressant-mechanism-of-action","display_name":"antidepressant mechanism","score":0.6439999938011169},{"id":"https://openalex.org/keywords/melatonin-receptors","display_name":"melatonin receptors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mt1-melatonin-receptor","display_name":"MT1 receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mt2-melatonin-receptor","display_name":"MT2 receptor","score":1.0},{"id":"https://openalex.org/keywords/circadian-synchronization","display_name":"circadian synchronization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7120000123977661},{"id":"https://openalex.org/keywords/5-ht2c-receptor-antagonism","display_name":"5-HT2C receptor antagonism","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.796999990940094},{"id":"https://openalex.org/keywords/monoamine-synthesis","display_name":"monoamine synthesis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/trophic-factors","display_name":"trophic factors","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2780798758","wikidata":"https://www.wikidata.org/wiki/Q395229","display_name":"Agomelatine","level":4,"score":0.8082062005996704},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6876852512359619},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6204624176025391},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5984870195388794},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5548238158226013},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.48739391565322876},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.45806553959846497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.443753182888031},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.41275596618652344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3956606090068817},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3942638039588928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3536306917667389},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.35136693716049194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32962265610694885},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28510403633117676},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2258378565311432}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185092016","doi":null,"is_oa":false,"landing_page_url":"http://www.jpsychopathol.it/issues/2011/vol17-3/10Biggio.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1867335213","https://openalex.org/W1965355495","https://openalex.org/W1987755278","https://openalex.org/W1993093741","https://openalex.org/W1999919402","https://openalex.org/W2003625071","https://openalex.org/W2003762546","https://openalex.org/W2003856043","https://openalex.org/W2030325164","https://openalex.org/W2035421865","https://openalex.org/W2047397850","https://openalex.org/W2072472304","https://openalex.org/W2106106014","https://openalex.org/W2106623141","https://openalex.org/W2115714588","https://openalex.org/W2122352230","https://openalex.org/W2129579709","https://openalex.org/W2161731199"],"related_works":["https://openalex.org/W136011305","https://openalex.org/W2052808361","https://openalex.org/W2009338054","https://openalex.org/W2101832118","https://openalex.org/W4230113980","https://openalex.org/W2139919471","https://openalex.org/W2011253374","https://openalex.org/W2070631875","https://openalex.org/W98812629","https://openalex.org/W1544997337"],"abstract_inverted_index":{"Summary":[0],"Agomelatine,":[1],"a":[2,7,26,58,92,97],"new":[3],"antidepressant":[4],"agent,":[5],"is":[6],"selective":[8,59],"agonist":[9],"of":[10,49,82,85,91,118],"the":[11,47,62,73,89,119,122],"MT1":[12],"and":[13,42,46,68,103,116,124],"MT2":[14],"melatonin":[15,55],"receptors.":[16],"Through":[17],"this":[18,21],"peculiar":[19],"action":[20],"drug,":[22],"like":[23],"melatonin,":[24],"has":[25],"key":[27],"role":[28,99],"in":[29,39,72,79,100,112,121,129],"synchronizing":[30,113],"circadian":[31,114],"rhythms,":[32],"which":[33],"are":[34],"known":[35],"to":[36,43,54],"be":[37],"perturbed":[38],"depressed":[40],"patients,":[41],"increase":[44,81],"neurogenesis":[45],"synthesis":[48],"trophic":[50],"factors.":[51],"In":[52],"contrast":[53],"Agomelatine":[56],"exerts":[57],"antagonism":[60],"on":[61,66],"5HT2c":[63],"receptors":[64],"localized":[65],"dopamine":[67],"noradrenaline":[69],"nerve":[70],"terminals":[71],"prefrontal":[74],"cortex.":[75],"This":[76],"mechanism":[77],"results":[78,111],"an":[80],"synaptic":[83],"concentration":[84],"both":[86],"monoamines":[87],"at":[88],"level":[90],"brain":[93],"area":[94],"that":[95],"plays":[96],"crucial":[98],"modulating":[101],"cognitive":[102,123],"emotional":[104],"function.":[105],"The":[106],"synergy":[107],"between":[108],"these":[109],"mechanisms":[110],"rhythms":[115],"improvement":[117],"decline":[120],"affective":[125],"symptoms":[126],"often":[127],"present":[128],"severe":[130],"unipolar":[131],"depression.":[132]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
