{"id":"https://openalex.org/W2185086745","doi":null,"title":"Development of a Novel Bis-indole Lead Series Active Against Category A and B Pathogens","display_name":"Development of a Novel Bis-indole Lead Series Active Against Category A and B Pathogens","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2185086745","mag":"2185086745"},"language":"en","primary_location":{"id":"mag:2185086745","doi":null,"is_oa":false,"landing_page_url":"http://www.microbiotix.com/posters/Bowlin%202010%20ASM%20Biodefense%20poster.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036883783","display_name":"Terry L. Bowlin","orcid":"https://orcid.org/0000-0002-9184-5791","observed_orcids":["https://orcid.org/0000-0002-9184-5791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terry L. Bowlin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9184-5791","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075308780","display_name":"Michelle M. Butler","orcid":"https://orcid.org/0009-0003-2850-4841","observed_orcids":["https://orcid.org/0009-0003-2850-4841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle M. Butler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6894-8621","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018266807","display_name":"John David Williams","orcid":"https://orcid.org/0000-0001-6609-3842","observed_orcids":["https://orcid.org/0000-0001-6609-3842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Williams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6609-3842","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Son Nguyen","orcid":"https://orcid.org/0000-0002-0475-5158","observed_orcids":["https://orcid.org/0000-0002-0475-5158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Son Nguyen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0475-5158","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026833151","display_name":"Norton P. Peet","orcid":"https://orcid.org/0000-0002-1047-1477","observed_orcids":["https://orcid.org/0000-0002-1047-1477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norton P. Peet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1047-1477","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904758","display_name":"Richard A. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073886576","display_name":"Donald E. Woods","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald E. Woods","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034761589","display_name":"Rekha G. Panchal","orcid":"https://orcid.org/0000-0001-8621-9078","observed_orcids":["https://orcid.org/0000-0001-8621-9078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rekha G. Panchal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8621-9078","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068707910","display_name":"Sina Bavari","orcid":"https://orcid.org/0000-0001-8424-5635","observed_orcids":["https://orcid.org/0000-0001-8424-5635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sina Bavari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8424-5635","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073100121","display_name":"Takehiko Mima","orcid":"https://orcid.org/0000-0003-2116-1498","observed_orcids":["https://orcid.org/0000-0003-2116-1498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takehiko Mima","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2116-1498","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018324088","display_name":"Herbert P. Schweizer","orcid":"https://orcid.org/0000-0002-8847-335X","observed_orcids":["https://orcid.org/0000-0002-8847-335X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert P. Schweizer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027964140","display_name":"Gretchen Berg","orcid":"https://orcid.org/0000-0002-3295-0794","observed_orcids":["https://orcid.org/0000-0002-3295-0794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gretchen Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103581151","display_name":"Susan K. Weir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan C. Weir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110283204","display_name":"Megan Murphy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan K. Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011977345","display_name":"Jon D. Goguen","orcid":"https://orcid.org/0000-0002-1372-1697","observed_orcids":["https://orcid.org/0000-0002-1372-1697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon D. Goguen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1372-1697","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030132181","display_name":"Donald T. Moir","orcid":"https://orcid.org/0000-0002-8625-0312","observed_orcids":["https://orcid.org/0000-0002-8625-0312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald T. Moir","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8625-0312","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1906173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.1160999983549118,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yersinia-pestis","display_name":"Yersinia pestis","score":0.921999990940094},{"id":"https://openalex.org/keywords/francisella-tularensis","display_name":"Francisella tularensis","score":1.0},{"id":"https://openalex.org/keywords/bacillus-anthracis","display_name":"Bacillus anthracis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/burkholderia-mallei","display_name":"Burkholderia mallei","score":0.9549999833106995},{"id":"https://openalex.org/keywords/burkholderia-pseudomallei","display_name":"Burkholderia pseudomallei","score":1.0},{"id":"https://openalex.org/keywords/ciprofloxacin-resistance","display_name":"ciprofloxacin resistance","score":0.7369999885559082},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7200000286102295},{"id":"https://openalex.org/keywords/in-vivo-efficacy","display_name":"in vivo efficacy","score":0.6620000004768372},{"id":"https://openalex.org/keywords/mouse-model-of-infection","display_name":"mouse infection model","score":0.8840000033378601},{"id":"https://openalex.org/keywords/anthrax","display_name":"anthrax","score":0.5740000009536743},{"id":"https://openalex.org/keywords/tularemia","display_name":"tularemia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/melioidosis","display_name":"melioidosis","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2779110727","wikidata":"https://www.wikidata.org/wiki/Q140475","display_name":"Burkholderia pseudomallei","level":3,"score":0.7804446220397949},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7510355710983276},{"id":"https://openalex.org/C2780239966","wikidata":"https://www.wikidata.org/wiki/Q614156","display_name":"Bacillus anthracis","level":3,"score":0.6528723239898682},{"id":"https://openalex.org/C2778222588","wikidata":"https://www.wikidata.org/wiki/Q153875","display_name":"Yersinia pestis","level":4,"score":0.55916827917099},{"id":"https://openalex.org/C2780467176","wikidata":"https://www.wikidata.org/wiki/Q1003460","display_name":"Francisella tularensis","level":4,"score":0.5509844422340393},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5258508324623108},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5048335194587708},{"id":"https://openalex.org/C2779775996","wikidata":"https://www.wikidata.org/wiki/Q963944","display_name":"Melioidosis","level":2,"score":0.4724105894565582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43097180128097534},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.39637845754623413},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3752426505088806},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31953972578048706},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.14948409795761108},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.068980872631073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185086745","doi":null,"is_oa":false,"landing_page_url":"http://www.microbiotix.com/posters/Bowlin%202010%20ASM%20Biodefense%20poster.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2150754866","https://openalex.org/W2126149426","https://openalex.org/W7125637438","https://openalex.org/W2807157229","https://openalex.org/W2094106788","https://openalex.org/W4405255812","https://openalex.org/W2135836078","https://openalex.org/W2185316526","https://openalex.org/W2467034182","https://openalex.org/W2142719763"],"abstract_inverted_index":{"SUMMARY":[0],"Methods:":[1],"Minimal":[2],"Inhibitory":[3],"Concentration":[4],"(MIC)":[5],"assays":[6],"were":[7,54,65,95],"performed":[8],"against":[9,87,98,110],"3":[10,91],"Category":[11,22,114],"A":[12,118,134],"(Yersinia":[13],"pestis,":[14],"Francisella":[15],"tularensis":[16],"and":[17,20,26,45,62,90,154],"B.":[18,27,43,46,88,152,155],"anthracis)":[19],"2":[21],"B":[23,136],"(Burkholderia":[24],"pseudomallei":[25,47,156],"mallei)":[28],"bacterial":[29,52],"species":[30],"using":[31],"CLSI-recommended":[32],"protocols.":[33],"In":[34],"vivo":[35],"efficacy":[36],"was":[37,108],"determined":[38],"in":[39,49,148],"murine":[40,149],"models":[41,150],"of":[42,92,120,151],"mallei":[44,153],"infection":[48,157],"which":[50,129],"the":[51,68,93,111],"strains":[53,116],"administered":[55,159],"by":[56,67,160],"intraperitoneal":[57],"(ip)":[58],"or":[59,70,163],"intranasal":[60],"routes":[61],"test":[63],"compounds":[64,94,143],"dispensed":[66],"ip":[69,162],"intravenous":[71],"(IV)":[72],"routes.":[73,165],"Results:":[74],"The":[75],"4":[76,112],"original":[77],"bI":[78,124],"derivatives":[79],"displayed":[80],"antibacterial":[81,106],"potencies":[82],"ranging":[83],"from":[84],"0.1-1.3":[85],"\u00b5g/mL":[86],"anthracis,":[89],"equally":[96],"potent":[97,123],"a":[99,135,145],"high":[100,105],"level":[101],"cipro-resistant":[102],"strain.":[103],"Similarly":[104],"potency":[107],"observed":[109],"Gram-negative":[113],"A/B":[115],"tested.":[117],"series":[119],"new":[121],"more":[122],"analogs":[125],"have":[126],"been":[127],"synthesized":[128],"exhibit":[130],"broad":[131],"spectrum":[132],"category":[133],"activity":[137],"(MIC":[138],"\u2264":[139],"0.1":[140],"\u00b5g/mL).":[141],"Finally,":[142],"demonstrated":[144],"protective":[146],"effect":[147],"when":[158],"either":[161],"IV":[164]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
