{"id":"https://openalex.org/W2185068768","doi":null,"title":"Interaction between genetic and dietary factors affecting cardiovascular risk","display_name":"Interaction between genetic and dietary factors affecting cardiovascular risk","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2185068768","mag":"2185068768"},"language":"en","primary_location":{"id":"mag:2185068768","doi":null,"is_oa":false,"landing_page_url":"https://apjcn.nhri.org.tw/server/APJCN/14/s/72.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034687856","display_name":"E Shyong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Shyong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tai MBChB","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tai MBChB","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110092070","display_name":"Chee Eng Tan","orcid":"https://orcid.org/0000-0003-1687-5867","observed_orcids":["https://orcid.org/0000-0003-1687-5867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chee Eng Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2877,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52886512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7300000190734863},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.671999990940094},{"id":"https://openalex.org/keywords/dietary-factors","display_name":"dietary factors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.6430000066757202},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8730000257492065},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.828000009059906},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9860000014305115},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7009999752044678},{"id":"https://openalex.org/keywords/urban-lifestyle","display_name":"urban lifestyle","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C137403100","wikidata":"https://www.wikidata.org/wiki/Q41710","display_name":"Ethnic group","level":2,"score":0.7278009057044983},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5991237163543701},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5555854439735413},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5227296948432922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4732542634010315},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4564421772956848},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.37421634793281555},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3315609395503998},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3074305057525635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2744062542915344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2738295793533325},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23332706093788147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1508910357952118},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2185068768","doi":null,"is_oa":false,"landing_page_url":"https://apjcn.nhri.org.tw/server/APJCN/14/s/72.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1926790482","https://openalex.org/W1971226909","https://openalex.org/W1982579882","https://openalex.org/W1986550414","https://openalex.org/W1988740624","https://openalex.org/W1998217994","https://openalex.org/W2001158939","https://openalex.org/W2005247682","https://openalex.org/W2007602954","https://openalex.org/W2007689102","https://openalex.org/W2056919254","https://openalex.org/W2058527397","https://openalex.org/W2061740349","https://openalex.org/W2074843721","https://openalex.org/W2075401586","https://openalex.org/W2080227700","https://openalex.org/W2086028454","https://openalex.org/W2087403702","https://openalex.org/W2094386887","https://openalex.org/W2094981066","https://openalex.org/W2096148819","https://openalex.org/W2100080260","https://openalex.org/W2103094551","https://openalex.org/W2103969784","https://openalex.org/W2107950372","https://openalex.org/W2112334970","https://openalex.org/W2113595490","https://openalex.org/W2115930787","https://openalex.org/W2119806364","https://openalex.org/W2123337267","https://openalex.org/W2125127017","https://openalex.org/W2129968563","https://openalex.org/W2135789853","https://openalex.org/W2140574698","https://openalex.org/W2140755927","https://openalex.org/W2143542161","https://openalex.org/W2144422677","https://openalex.org/W2146622197","https://openalex.org/W2152316341","https://openalex.org/W2154184102","https://openalex.org/W2158896434","https://openalex.org/W2160849920","https://openalex.org/W2160858945","https://openalex.org/W2162124573","https://openalex.org/W2164978843","https://openalex.org/W2185444021","https://openalex.org/W2296684237","https://openalex.org/W2596042202"],"related_works":["https://openalex.org/W2037841594","https://openalex.org/W1998879850","https://openalex.org/W2127088013","https://openalex.org/W2077857080","https://openalex.org/W2406532183","https://openalex.org/W2156081634","https://openalex.org/W2622839200","https://openalex.org/W2188830815","https://openalex.org/W2053895986","https://openalex.org/W2133452869"],"abstract_inverted_index":{"Socio-economic":[0],"development":[1],"and":[2,38,80,128,166,199],"progressive":[3],"urbanization":[4],"has":[5],"been":[6],"accompanied":[7],"by":[8,74],"an":[9,42,59,151],"increase":[10,25],"in":[11,18,34,83,174],"the":[12,75,91,113,145,177,184,190,208,218,228,234],"rates":[13,92],"of":[14,23,77,93,126,144,183,214,230],"cardiovascular":[15],"disease":[16],"(CVD)":[17],"developing":[19],"countries.":[20],"The":[21,45],"cause":[22],"this":[24],"is":[26,29,72,160],"multifactorial.":[27],"It":[28],"very":[30],"likely":[31],"that":[32,47,63,122,147,225],"changes":[33],"lifestyle":[35,222],"(particularly":[36],"diet":[37,159],"physical":[39],"activity)":[40],"play":[41],"important":[43],"role.":[44],"evidence":[46],"some":[48],"ethnic":[49,116,135],"groups":[50,117],"may":[51,66,216],"be":[52,68],"at":[53,180],"particular":[54],"risk":[55],"when":[56],"exposed":[57],"to":[58,97,101,111,133,141,150],"urban":[60,152],"environment":[61],"suggests":[62],"genetic":[64,106,129,138],"factors":[65,107,130],"also":[67],"involved.":[69],"This":[70],"situation":[71],"exemplified":[73],"experience":[76],"Chinese,":[78],"Malays":[79],"Asian":[81,86],"Indians":[82,87],"Singapore,":[84],"where":[85],"have":[88,195],"three":[89],"times":[90],"myocardial":[94],"infarction":[95],"compared":[96],"Chinese":[98],"despite":[99],"exposure":[100],"a":[102,123,156],"similar":[103],"environment.":[104],"However,":[105],"do":[108],"not":[109],"seem":[110],"explain":[112],"differences":[114],"between":[115],"either.":[118],"Rather,":[119],"it":[120],"appears":[121],"complex":[124],"interplay":[125],"environmental":[127],"give":[131],"rise":[132],"these":[134],"differences.":[136],"Some":[137],"variants":[139],"appear":[140],"identify":[142],"subgroups":[143],"population":[146],"are":[148],"maladapted":[149],"lifestyle.":[153],"For":[154],"example,":[155],"high":[157],"fat":[158],"associated":[161],"with":[162,176,189],"higher":[163,200],"serum":[164,197],"triglyceride":[165,198],"lower":[167,196],"HDL-cholesterol":[168],"concentrations":[169],"(a":[170,203],"more":[171],"atherogenic":[172,205],"phenotype)":[173,206],"those":[175,188],"TT":[178],"genotype":[179],"position":[181],"-514":[182],"LIPC":[185],"locus":[186],"while":[187],"CC":[191],"or":[192],"CT":[193],"genotypes":[194],"HDLcholesterol":[201],"concentration":[202],"less":[204],"under":[207],"same":[209],"dietary":[210],"conditions.":[211],"These":[212],"types":[213],"findings":[215],"provide":[217],"basis":[219],"for":[220,233],"personalized":[221],"modification":[223],"therapy":[224,232],"will":[226],"optimize":[227],"benefits":[229],"such":[231],"individual":[235],"concerned.":[236]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}