{"id":"https://openalex.org/W2185015944","doi":"https://doi.org/10.1101/gad.1958410","title":"Constitutively active NF-\u03baB triggers systemic TNF\u03b1-dependent inflammation and localized TNF\u03b1-independent inflammatory disease","display_name":"Constitutively active NF-\u03baB triggers systemic TNF\u03b1-dependent inflammation and localized TNF\u03b1-independent inflammatory disease","publication_year":2010,"publication_date":"2010-08-15","ids":{"openalex":"https://openalex.org/W2185015944","doi":"https://doi.org/10.1101/gad.1958410","mag":"2185015944","pmid":"https://pubmed.ncbi.nlm.nih.gov/20713516","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922500"},"language":"en","primary_location":{"id":"doi:10.1101/gad.1958410","doi":"https://doi.org/10.1101/gad.1958410","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1958410","pdf_url":"http://genesdev.cshlp.org/content/24/16/1709.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/24/16/1709.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063863355","display_name":"Jie Dong","orcid":"https://orcid.org/0000-0003-0493-1665","observed_orcids":["https://orcid.org/0000-0003-0493-1665"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Dong","raw_affiliation_strings":["Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008014053","display_name":"Eijiro Jimi","orcid":"https://orcid.org/0000-0003-3616-5299","observed_orcids":["https://orcid.org/0000-0003-3616-5299"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eijiro Jimi","raw_affiliation_strings":["Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024405586","display_name":"Caroline J. Zeiss","orcid":"https://orcid.org/0000-0003-1181-3544","observed_orcids":["https://orcid.org/0000-0003-1181-3544"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Zeiss","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA;","Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA;","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030284090","display_name":"Matthew S. Hayden","orcid":"https://orcid.org/0000-0003-1670-6430","observed_orcids":["https://orcid.org/0000-0003-1670-6430"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Hayden","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, New York 10032,\n                           USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, New York 10032,\n                           USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044844412","display_name":"Sankar Ghosh","orcid":"https://orcid.org/0000-0002-3227-0588","observed_orcids":["https://orcid.org/0000-0002-3227-0588"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sankar Ghosh","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, New York 10032,\n                           USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, New York 10032,\n                           USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"16","first_page":"1709","last_page":"1717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8180000185966492},{"id":"https://openalex.org/keywords/knock-in-mice","display_name":"knock-in mice","score":0.6140000224113464},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/keratitis","display_name":"keratitis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sjogren-s-syndrome","display_name":"Sj\u00f6gren's syndrome","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.7889999747276306},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5590000152587891},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.817623496055603},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7376852035522461},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6290469765663147},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6289798021316528},{"id":"https://openalex.org/C2909898526","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Corneal inflammation","level":3,"score":0.5219218730926514},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.49896883964538574},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.4506523609161377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42628753185272217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3593907356262207}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055879","descriptor_name":"Gene Knock-In Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1101/gad.1958410","doi":"https://doi.org/10.1101/gad.1958410","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1958410","pdf_url":"http://genesdev.cshlp.org/content/24/16/1709.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},{"id":"pmid:20713516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20713516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2922500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2922500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"},{"id":"mag:2185015944","doi":null,"is_oa":false,"landing_page_url":"http://genesdev.cshlp.org/content/24/16/1709.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1101/gad.1958410","doi":"https://doi.org/10.1101/gad.1958410","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1958410","pdf_url":"http://genesdev.cshlp.org/content/24/16/1709.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6565038846","display_name":"Regulation of NF-kB and 1kB Proteins","funder_award_id":"R37AI033443","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7428659700","display_name":"Regulation of NF-kB transcriptional activity","funder_award_id":"R01AI066109","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2185015944.pdf","grobid_xml":"https://content.openalex.org/works/W2185015944.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W25872690","https://openalex.org/W71637011","https://openalex.org/W1535444616","https://openalex.org/W1977707794","https://openalex.org/W1984860462","https://openalex.org/W1985118687","https://openalex.org/W1993524190","https://openalex.org/W2002926183","https://openalex.org/W2006470470","https://openalex.org/W2011083985","https://openalex.org/W2040389158","https://openalex.org/W2066032479","https://openalex.org/W2067938485","https://openalex.org/W2073415262","https://openalex.org/W2087634948","https://openalex.org/W2088344821","https://openalex.org/W2094863064","https://openalex.org/W2117817795","https://openalex.org/W2122343048","https://openalex.org/W2123105952","https://openalex.org/W2129819015","https://openalex.org/W2131162745","https://openalex.org/W2140323371","https://openalex.org/W2148119611","https://openalex.org/W2151146904","https://openalex.org/W2152152362","https://openalex.org/W2159087408","https://openalex.org/W2163625494"],"related_works":["https://openalex.org/W1912988777","https://openalex.org/W2171945340","https://openalex.org/W7098958697","https://openalex.org/W2064711537","https://openalex.org/W3149021305","https://openalex.org/W3127391586","https://openalex.org/W3119653669","https://openalex.org/W2257595925","https://openalex.org/W7095461268","https://openalex.org/W4407772475"],"abstract_inverted_index":{"NF-kappaB":[0,18,33,48,152],"is":[1,178],"well":[2],"established":[3],"as":[4,171],"a":[5,38,43,61,104,175],"key":[6],"component":[7],"of":[8,32,47,79,107,127,190],"the":[9,13,30,108],"inflammatory":[10,22,167],"response.":[11],"However,":[12,111,165],"precise":[14],"mechanisms":[15],"through":[16,161],"which":[17],"activation":[19],"contributes":[20],"to":[21,103,118,133],"disease":[23,168],"states":[24],"remain":[25],"poorly":[26],"defined.":[27],"To":[28],"test":[29],"role":[31],"in":[34,68,86,136,180],"inflammation,":[35,156],"we":[36],"created":[37],"knock-in":[39,81],"mouse":[40],"that":[41,66,134,177],"expresses":[42],"constitutively":[44,150],"active":[45,151],"form":[46],"p65":[49],"dimers.":[50],"These":[51],"mice":[52,82,96,116],"are":[53,183,188],"born":[54],"at":[55],"normal":[56],"Mendelian":[57],"ratios,":[58],"but":[59,187],"display":[60,119],"progressive,":[62],"systemic":[63,155],"hyperinflammatory":[64,109],"condition":[65,176],"results":[67,146],"severe":[69],"runting":[70],"and,":[71],"typically,":[72],"death":[73],"8-20":[74],"d":[75],"after":[76],"birth.":[77],"Examination":[78],"homozygous":[80],"demonstrates":[83],"significant":[84],"increases":[85],"proinflammatory":[87],"cytokines":[88],"and":[89,130],"chemokines.":[90],"Remarkably,":[91],"crossing":[92],"this":[93],"strain":[94],"with":[95],"lacking":[97],"TNF":[98,163],"receptor":[99],"1":[100],"(TNFR1)":[101],"leads":[102],"complete":[105],"rescue":[106],"phenotype.":[110],"upon":[112],"aging,":[113],"these":[114],"rescued":[115],"begin":[117],"chronic":[120],"keratitis":[121,172],"accompanied":[122],"by":[123],"increased":[124,162],"corneal":[125],"expression":[126],"TNFalpha,":[128],"IL-1beta,":[129],"MMP-9,":[131],"similar":[132],"seen":[135,179],"human":[137],"keratoconjunctivitis":[138],"sicca":[139],"(KCS)":[140],"or":[141,173],"\"dry":[142],"eyes.\"":[143],"Therefore,":[144],"our":[145],"show":[147],"that,":[148],"while":[149],"can":[153],"trigger":[154],"it":[157],"does":[158],"so":[159],"indirectly,":[160],"production.":[164],"certain":[166],"states,":[169],"such":[170],"KCS,":[174],"Sjogren's":[181],"syndrome,":[182],"dependent":[184],"on":[185],"NF-kappaB,":[186],"independent":[189],"TNFR1":[191],"signaling.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}