{"id":"https://openalex.org/W2184997641","doi":"https://doi.org/10.33549/physiolres.931739","title":"Orexins Activates Protein Kinase C-Mediated Ca2+ Signaling in Isolated Rat Primary Sensory Neurons","display_name":"Orexins Activates Protein Kinase C-Mediated Ca2+ Signaling in Isolated Rat Primary Sensory Neurons","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2184997641","doi":"https://doi.org/10.33549/physiolres.931739","mag":"2184997641","pmid":"https://pubmed.ncbi.nlm.nih.gov/19537922"},"language":"en","primary_location":{"id":"doi:10.33549/physiolres.931739","doi":"https://doi.org/10.33549/physiolres.931739","is_oa":true,"landing_page_url":"https://doi.org/10.33549/physiolres.931739","pdf_url":"https://doi.org/10.33549/physiolres.931739","source":{"id":"https://openalex.org/S4210199525","display_name":"Physiological Research","issn_l":"0862-8408","issn":["0862-8408","1802-9973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314155","host_organization_name":"Institute of Physiology of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314155","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Physiology of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.33549/physiolres.931739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054598270","display_name":"Mete \u00d6zcan","orcid":"https://orcid.org/0000-0002-5551-4880","observed_orcids":["https://orcid.org/0000-0002-5551-4880"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M Ozcan","raw_affiliation_strings":["Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","Department of Biophysics, Firat University Faculty of Medicine, Elazig, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]},{"raw_affiliation_string":"Department of Biophysics, Firat University Faculty of Medicine, Elazig, Turkey,","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044320853","display_name":"Ahmet Ayar","orcid":"https://orcid.org/0000-0002-9449-9564","observed_orcids":["https://orcid.org/0000-0002-9449-9564"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A Ayar","raw_affiliation_strings":["Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016928554","display_name":"\u0130hsan Serhatlio\u011flu","orcid":"https://orcid.org/0000-0002-2384-7971","observed_orcids":["https://orcid.org/0000-0002-2384-7971"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]},{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"I Serhatlioglu","raw_affiliation_strings":["Department of Biophysics, Firat University Faculty of Medicine, Elazig, Turkey,","Karadeniz Technical University , Faculty of Medicine (TIP FAKULTESI) , Department of Physiology TR-61080 , Trabzon , Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Firat University Faculty of Medicine, Elazig, Turkey,","institution_ids":["https://openalex.org/I143396566"]},{"raw_affiliation_string":"Karadeniz Technical University , Faculty of Medicine (TIP FAKULTESI) , Department of Physiology TR-61080 , Trabzon , Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081173844","display_name":"Erg\u00fcl Al\u00e7in","orcid":"https://orcid.org/0000-0002-0927-0491","observed_orcids":["https://orcid.org/0000-0002-0927-0491"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"E Alcin","raw_affiliation_strings":["Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106225696","display_name":"Zafer \u015eahin","orcid":"https://orcid.org/0000-0001-7982-7155","observed_orcids":["https://orcid.org/0000-0001-7982-7155"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Z Sahin","raw_affiliation_strings":["Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","Prague , Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]},{"raw_affiliation_string":"Prague , Czech Republic","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074125485","display_name":"Haluk Kele\u015ftimur","orcid":"https://orcid.org/0000-0001-9971-5716","observed_orcids":["https://orcid.org/0000-0001-9971-5716"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H Kelestimur","raw_affiliation_strings":["Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":800,"currency":"EUR","value_usd":862},"apc_paid":{"value":800,"currency":"EUR","value_usd":862},"fwci":2.5965,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.88847765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"59","issue":"2","first_page":"255","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.6970000267028809},{"id":"https://openalex.org/keywords/orexin-a","display_name":"orexin-A","score":0.9210000038146973},{"id":"https://openalex.org/keywords/orexin-b","display_name":"orexin B","score":1.0},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9869999885559082},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.8930000066757202},{"id":"https://openalex.org/keywords/primary-sensory-neurons","display_name":"primary sensory neurons","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/orexin-1-receptor","display_name":"orexin-1 receptor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chelerythrine","display_name":"chelerythrine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2776108454","wikidata":"https://www.wikidata.org/wiki/Q5089853","display_name":"Chelerythrine","level":4,"score":0.8656258583068848},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.7769957780838013},{"id":"https://openalex.org/C2776119998","wikidata":"https://www.wikidata.org/wiki/Q1070023","display_name":"Orexin-A","level":5,"score":0.7525773048400879},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6996182799339294},{"id":"https://openalex.org/C2779605129","wikidata":"https://www.wikidata.org/wiki/Q24785218","display_name":"Orexin receptor","level":5,"score":0.6975966095924377},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.6820149421691895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5952763557434082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5695470571517944},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5454117655754089},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.5292878746986389},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.48389944434165955},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.46441027522087097},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.44032496213912964},{"id":"https://openalex.org/C2778470358","wikidata":"https://www.wikidata.org/wiki/Q908761","display_name":"Fura-2","level":4,"score":0.41325563192367554},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39033716917037964},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3896626830101013},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3556444048881531},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.32867544889450073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24705862998962402},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2301601767539978},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.20407873392105103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1809697151184082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1521688997745514},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.09854206442832947},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009287","descriptor_name":"Naphthyridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.33549/physiolres.931739","doi":"https://doi.org/10.33549/physiolres.931739","is_oa":true,"landing_page_url":"https://doi.org/10.33549/physiolres.931739","pdf_url":"https://doi.org/10.33549/physiolres.931739","source":{"id":"https://openalex.org/S4210199525","display_name":"Physiological Research","issn_l":"0862-8408","issn":["0862-8408","1802-9973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314155","host_organization_name":"Institute of Physiology of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314155","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Physiology of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Research","raw_type":"journal-article"},{"id":"pmid:19537922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19537922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological research","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/42186","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/42186","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/54130","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/54130","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.33549/physiolres.931739","doi":"https://doi.org/10.33549/physiolres.931739","is_oa":true,"landing_page_url":"https://doi.org/10.33549/physiolres.931739","pdf_url":"https://doi.org/10.33549/physiolres.931739","source":{"id":"https://openalex.org/S4210199525","display_name":"Physiological Research","issn_l":"0862-8408","issn":["0862-8408","1802-9973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314155","host_organization_name":"Institute of Physiology of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314155","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Physiology of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2184997641.pdf","grobid_xml":"https://content.openalex.org/works/W2184997641.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W152287137","https://openalex.org/W339414464","https://openalex.org/W1570969286","https://openalex.org/W1764472238","https://openalex.org/W1838211711","https://openalex.org/W1855586171","https://openalex.org/W1959892192","https://openalex.org/W1965055739","https://openalex.org/W1984033377","https://openalex.org/W1997744254","https://openalex.org/W2008099612","https://openalex.org/W2017200167","https://openalex.org/W2027740042","https://openalex.org/W2033547042","https://openalex.org/W2036325467","https://openalex.org/W2042847772","https://openalex.org/W2047094134","https://openalex.org/W2051408504","https://openalex.org/W2070390515","https://openalex.org/W2071633080","https://openalex.org/W2072044677","https://openalex.org/W2083489519","https://openalex.org/W2104631706","https://openalex.org/W2115902692","https://openalex.org/W2116847572","https://openalex.org/W2130717252","https://openalex.org/W2152211310","https://openalex.org/W2163650198","https://openalex.org/W2165346507","https://openalex.org/W2295420473","https://openalex.org/W2413248623","https://openalex.org/W2738716652","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1979669476","https://openalex.org/W756349189","https://openalex.org/W7143618542","https://openalex.org/W2763834246","https://openalex.org/W2996347227","https://openalex.org/W4249746134","https://openalex.org/W2294831597","https://openalex.org/W2165346507","https://openalex.org/W1496388851","https://openalex.org/W6998973"],"abstract_inverted_index":{"Previous":[0],"results":[1,158],"have":[2,176],"suggested":[3],"that":[4,144,160],"orexins":[5,161],"causes":[6],"a":[7,23],"rise":[8],"of":[9,36],"intracellular":[10,163],"free":[11],"calcium":[12,89,164],"([Ca(2+)](i))":[13],"in":[14,25,51,73,166],"cultured":[15,167],"rat":[16,168],"dorsal":[17],"root":[18],"ganglion":[19],"(DRG)":[20],"neurons,":[21],"implicating":[22],"role":[24],"nociception,":[26],"but":[27],"the":[28,34,37,44,48,71,88,121,148],"underlying":[29],"mechanism":[30],"is":[31],"unknown.":[32],"Hence,":[33],"aim":[35],"present":[38],"study":[39],"was":[40,141],"to":[41,91,138,151],"investigate":[42],"whether":[43],"orexins-mediated":[45],"signaling":[46,165],"involves":[47],"PKC":[49,112],"pathways":[50],"these":[52],"sensory":[53,169],"neurons.":[54],"Cultured":[55],"DRG":[56],"neurons":[57,170],"were":[58,68],"loaded":[59],"with":[60],"1":[61],"micromol":[62],"Fura-2":[63],"AM":[64],"and":[65,93,102,116,131,182],"[Ca(2+)](i)":[66,125,149],"responses":[67,90],"quantified":[69],"by":[70],"changes":[72],"340/380":[74],"ratio":[75],"using":[76],"fluorescence":[77],"imaging":[78],"system.":[79],"The":[80,111],"orexin-1":[81],"receptor":[82],"antagonist":[83],"SB-334867-A":[84],"(1":[85],"microM)":[86,118],"inhibited":[87,147],"orexin-A":[92,122],"orexin-B":[94],"(59.1+/-5.1":[95],"%":[96,104,128],"vs.":[97,105],"200":[98,106,152],"nM":[99,107,153],"orexin-A,":[100],"n=8,":[101],"67+/-3.8":[103],"orexin-B,":[108],"n=12,":[109],"respectively).":[110],"inhibitor":[113],"chelerythrine":[114,145],"(10":[115],"100":[117],"significantly":[119],"decreased":[120],"(200":[123],"nM)-induced":[124],"increase":[126],"(59.4+/-4.8":[127],"P<0.01,":[129,134],"n=10":[130],"4.9+/-1.6":[132],"%,":[133],"n=9)":[135],"versus":[136],"response":[137,150],"orexin-A).":[139],"It":[140],"also":[142],"found":[143],"dose-dependently":[146],"orexin-B.":[154],"In":[155],"conclusion,":[156],"our":[157],"suggest":[159],"activate":[162],"through":[171],"PKC-dependent":[172],"pathway,":[173],"which":[174],"may":[175],"important":[177],"implications":[178],"for":[179],"nociceptive":[180],"modulation":[181],"pain.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}