{"id":"https://openalex.org/W2184968367","doi":null,"title":"Comparative efficacy of Choline vs Clitoria ternatea Aqueous root extract supplements in attenuating maternal separation stress induced alterations in postnatal rat hippocampus","display_name":"Comparative efficacy of Choline vs Clitoria ternatea Aqueous root extract supplements in attenuating maternal separation stress induced alterations in postnatal rat hippocampus","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2184968367","mag":"2184968367"},"language":"en","primary_location":{"id":"mag:2184968367","doi":null,"is_oa":false,"landing_page_url":"https://eprints.manipal.edu/141997/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112274178","display_name":"Prathibha Maria D Almeida","orcid":"https://orcid.org/0000-0003-3707-3564","observed_orcids":["https://orcid.org/0000-0003-3707-3564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prathibha Maria D Almeida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001363452","display_name":"K. Dilip Murthy","orcid":"https://orcid.org/0000-0002-5853-2654","observed_orcids":["https://orcid.org/0000-0002-5853-2654"]},"institutions":[{"id":"https://openalex.org/I161371597","display_name":"Universiti of Malaysia Sabah","ror":"https://ror.org/040v70252","country_code":"MY","type":"education","lineage":["https://openalex.org/I161371597"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"K. Dilip Murthy","raw_affiliation_strings":["\u2020Universiti Malaysia Sabah"],"raw_orcid":"https://orcid.org/0000-0002-5853-2654","affiliations":[{"raw_affiliation_string":"\u2020Universiti Malaysia Sabah","institution_ids":["https://openalex.org/I161371597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104727865","display_name":"Shobha Ullas Kamath","orcid":"https://orcid.org/0000-0002-9896-0872","observed_orcids":["https://orcid.org/0000-0002-9896-0872"]},"institutions":[{"id":"https://openalex.org/I76414455","display_name":"Kasturba Medical College, Manipal","ror":"https://ror.org/05hg48t65","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I76414455"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shobha Kamath","raw_affiliation_strings":["Kasturba Medical College, Manipal"],"raw_orcid":"https://orcid.org/0000-0002-9896-0872","affiliations":[{"raw_affiliation_string":"Kasturba Medical College, Manipal","institution_ids":["https://openalex.org/I76414455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062263634","display_name":"S. Kiranmai","orcid":"https://orcid.org/0000-0002-4888-7056","observed_orcids":["https://orcid.org/0000-0002-4888-7056"]},"institutions":[{"id":"https://openalex.org/I4210093039","display_name":"Melaka Manipal Medical College","ror":"https://ror.org/00g2cf802","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210093039"]},{"id":"https://openalex.org/I4210121274","display_name":"Manipal University College Malaysia","ror":"https://ror.org/02z88n164","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210121274"]}],"countries":["IN","MY"],"is_corresponding":false,"raw_author_name":"S. Kiranmai","raw_affiliation_strings":["Department of Physiology, Melaka Manipal Medical College, Manipal"],"raw_orcid":"https://orcid.org/0000-0002-4888-7056","affiliations":[{"raw_affiliation_string":"Department of Physiology, Melaka Manipal Medical College, Manipal","institution_ids":["https://openalex.org/I4210093039","https://openalex.org/I4210121274"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8002,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77424529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"6","first_page":"662","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choline-supplementation","display_name":"choline supplementation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ca1","display_name":"CA1","score":0.5920000076293945},{"id":"https://openalex.org/keywords/ca3","display_name":"CA3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.6299999952316284},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.814011812210083},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.8001061677932739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5355510711669922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5172424912452698},{"id":"https://openalex.org/C2776794632","wikidata":"https://www.wikidata.org/wiki/Q312265","display_name":"Clitoria ternatea","level":3,"score":0.4582771956920624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4420391917228699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27076035737991333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1201925277709961},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184968367","doi":null,"is_oa":false,"landing_page_url":"https://eprints.manipal.edu/141997/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1593448845","https://openalex.org/W1624170337","https://openalex.org/W2075404405","https://openalex.org/W2136352610","https://openalex.org/W2562643285"],"related_works":["https://openalex.org/W3211093813","https://openalex.org/W2198661605","https://openalex.org/W2896038684","https://openalex.org/W7052822907","https://openalex.org/W7214967944","https://openalex.org/W2034634766","https://openalex.org/W1521972708","https://openalex.org/W4381166293","https://openalex.org/W1924491814","https://openalex.org/W2068734125"],"abstract_inverted_index":{"Perinatal":[0],"maternal":[1],"separation":[2],"stress":[3],"(PMSS)":[4],"causes":[5],"brain":[6,16],"deficits":[7,54,118,202],"that":[8],"last":[9],"through":[10],"ageing.":[11],"Choline":[12,102],"is":[13,25,37,196],"essential":[14],"for":[15,89],"development.":[17],"Alternately,":[18],"Clitorea":[19],"ternatea":[20],"aqueous":[21],"root":[22],"extract":[23],"(CTR)":[24],"proved":[26],"to":[27,39,87,97,107,125,135,180,191],"enhance":[28],"neural":[29,52,153,163,201],"plasticity":[30],"in":[31,48,55,119,128,143,156,165,174,183,199,203],"rat":[32,65],"hippocampus.":[33,62,204],"The":[34],"present":[35],"study":[36],"designed":[38],"elucidate":[40],"the":[41,100,111,126,181],"comparative":[42],"efficacy":[43],"of":[44,61,122,133,146,162,188],"choline":[45,149,192],"and":[46,58,103,158,168],"CTR":[47,80,104,134,177],"attenuating":[49,200],"PMSS":[50,75,78,88,114,175],"induced":[51],"cell":[53],"CA1,":[56],"CA3":[57,157],"DG":[59,169],"sub-regions":[60,121,145],"Inbred":[63],"Wistar":[64],"pups":[66,84],"were":[67,85,105],"divided":[68],"into":[69],"4":[70],"groups":[71,109],"-":[72],"Control,":[73],"PMSS,":[74],"+":[76,79,176],"Choline,":[77],"[n=6":[81],"pups/group].":[82],"All":[83],"subjected":[86],"6":[90],"hours/day":[91],"from":[92],"postnatal":[93],"day":[94],"(PND)":[95],"2":[96],"21":[98],"except":[99],"controls.":[101],"supplemented":[106],"appropriate":[108],"during":[110,193],"same":[112,127,182],"period.":[113],"caused":[115],"significant":[116],"neura":[117],"all":[120,144],"hippocampus":[123],"compared":[124,179,190],"normal":[129],"controls,":[130],"whereas":[131],"supplementation":[132,150,187],"these":[136,141],"rats":[137],"significantly":[138,172],"preserved":[139,151],"(p<0.001)":[140,152],"cells":[142,154,164],"hippocampus,":[147],"while":[148],"only":[155],"DG.":[159],"Moreover":[160],"preservation":[161],"CA1":[166],"(p<0.05)":[167],"(p<0.01)":[170],"was":[171],"greater":[173],"as":[178],"PMSS+":[184],"choline.":[185],"Thus,":[186],"CTR,":[189],"developmental":[194],"periods":[195],"more":[197],"effective":[198]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}