{"id":"https://openalex.org/W2184949593","doi":null,"title":"Zebrafish as a model for analysis of signaling pathways involved in cell growth, proliferation and development","display_name":"Zebrafish as a model for analysis of signaling pathways involved in cell growth, proliferation and development","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2184949593","mag":"2184949593"},"language":"en","primary_location":{"id":"pmh:oai:repository.bilkent.edu.tr:11693/15608","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11693/15608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11693/15608","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035992761","display_name":"Ceren Sucularl\u0131","orcid":"https://orcid.org/0000-0003-0627-7900","observed_orcids":["https://orcid.org/0000-0003-0627-7900"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ceren Sucularl\u0131","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035992761"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9990000128746033},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/development-biology","display_name":"development (biology)","score":0.6769999861717224},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8660448789596558},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6360946297645569},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5483159422874451},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5006663799285889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4152146577835083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33388638496398926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16560721397399902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06684723496437073}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.bilkent.edu.tr:11693/15608","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11693/15608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2184949593","doi":null,"is_oa":false,"landing_page_url":"http://www.thesis.bilkent.edu.tr/0006331.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.bilkent.edu.tr:11693/15608","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11693/15608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":177,"referenced_works":["https://openalex.org/W12917694","https://openalex.org/W1499500424","https://openalex.org/W1501975555","https://openalex.org/W1525939557","https://openalex.org/W1612352448","https://openalex.org/W1647597862","https://openalex.org/W1696199194","https://openalex.org/W1835059569","https://openalex.org/W1930957416","https://openalex.org/W1967815431","https://openalex.org/W1968077350","https://openalex.org/W1969491122","https://openalex.org/W1969886925","https://openalex.org/W1970156673","https://openalex.org/W1970731247","https://openalex.org/W1973164243","https://openalex.org/W1976261033","https://openalex.org/W1976687669","https://openalex.org/W1976726113","https://openalex.org/W1979312939","https://openalex.org/W1979403700","https://openalex.org/W1981805884","https://openalex.org/W1985847658","https://openalex.org/W1986304226","https://openalex.org/W1986515287","https://openalex.org/W1986885819","https://openalex.org/W1988739816","https://openalex.org/W1989076816","https://openalex.org/W1990228605","https://openalex.org/W1990639604","https://openalex.org/W1991294765","https://openalex.org/W1993836723","https://openalex.org/W1994833998","https://openalex.org/W1995979905","https://openalex.org/W1997554027","https://openalex.org/W2000054385","https://openalex.org/W2005463323","https://openalex.org/W2006195578","https://openalex.org/W2007080834","https://openalex.org/W2008394600","https://openalex.org/W2008932991","https://openalex.org/W2014092680","https://openalex.org/W2014238063","https://openalex.org/W2019574453","https://openalex.org/W2019796926","https://openalex.org/W2019926860","https://openalex.org/W2025358151","https://openalex.org/W2026162932","https://openalex.org/W2026694352","https://openalex.org/W2026728933","https://openalex.org/W2027021224","https://openalex.org/W2029815513","https://openalex.org/W2031435441","https://openalex.org/W2032208151","https://openalex.org/W2032211729","https://openalex.org/W2032863484","https://openalex.org/W2033661426","https://openalex.org/W2035029345","https://openalex.org/W2037745220","https://openalex.org/W2039215669","https://openalex.org/W2039758892","https://openalex.org/W2040217725","https://openalex.org/W2040588918","https://openalex.org/W2040653256","https://openalex.org/W2041041342","https://openalex.org/W2044108092","https://openalex.org/W2044814271","https://openalex.org/W2045463072","https://openalex.org/W2048566663","https://openalex.org/W2050192518","https://openalex.org/W2050658915","https://openalex.org/W2055248589","https://openalex.org/W2058991502","https://openalex.org/W2059328178","https://openalex.org/W2062211706","https://openalex.org/W2065735233","https://openalex.org/W2066125587","https://openalex.org/W2067541661","https://openalex.org/W2068169334","https://openalex.org/W2068265240","https://openalex.org/W2068966513","https://openalex.org/W2069272954","https://openalex.org/W2069906795","https://openalex.org/W2069929898","https://openalex.org/W2070329840","https://openalex.org/W2070681399","https://openalex.org/W2072780644","https://openalex.org/W2073904743","https://openalex.org/W2074939483","https://openalex.org/W2075292318","https://openalex.org/W2075380061","https://openalex.org/W2076172881","https://openalex.org/W2076379150","https://openalex.org/W2076796285","https://openalex.org/W2078274906","https://openalex.org/W2078840238","https://openalex.org/W2080589169","https://openalex.org/W2081083020","https://openalex.org/W2083187335","https://openalex.org/W2084112513","https://openalex.org/W2084544581","https://openalex.org/W2084680019","https://openalex.org/W2085511966","https://openalex.org/W2086145996","https://openalex.org/W2087524026","https://openalex.org/W2087673629","https://openalex.org/W2093909277","https://openalex.org/W2096223419","https://openalex.org/W2097214643","https://openalex.org/W2099057598","https://openalex.org/W2099345094","https://openalex.org/W2103381667","https://openalex.org/W2104381422","https://openalex.org/W2104455852","https://openalex.org/W2104850613","https://openalex.org/W2106787509","https://openalex.org/W2106882534","https://openalex.org/W2108244474","https://openalex.org/W2108274213","https://openalex.org/W2109193695","https://openalex.org/W2110577277","https://openalex.org/W2111849727","https://openalex.org/W2111874221","https://openalex.org/W2114918609","https://openalex.org/W2116815663","https://openalex.org/W2117539939","https://openalex.org/W2117848358","https://openalex.org/W2118030557","https://openalex.org/W2120441165","https://openalex.org/W2121863068","https://openalex.org/W2124386744","https://openalex.org/W2125121305","https://openalex.org/W2126736765","https://openalex.org/W2126882473","https://openalex.org/W2127068319","https://openalex.org/W2129756867","https://openalex.org/W2130024105","https://openalex.org/W2130916990","https://openalex.org/W2131179850","https://openalex.org/W2131660936","https://openalex.org/W2134138119","https://openalex.org/W2136526854","https://openalex.org/W2137476312","https://openalex.org/W2137672139","https://openalex.org/W2138667048","https://openalex.org/W2139473428","https://openalex.org/W2139478238","https://openalex.org/W2141735759","https://openalex.org/W2142162357","https://openalex.org/W2142506125","https://openalex.org/W2145868971","https://openalex.org/W2147131744","https://openalex.org/W2148911704","https://openalex.org/W2149079106","https://openalex.org/W2149139293","https://openalex.org/W2149783560","https://openalex.org/W2151812144","https://openalex.org/W2152288672","https://openalex.org/W2154903097","https://openalex.org/W2155400170","https://openalex.org/W2155616315","https://openalex.org/W2156643308","https://openalex.org/W2157741655","https://openalex.org/W2158612356","https://openalex.org/W2159516023","https://openalex.org/W2159686118","https://openalex.org/W2163210901","https://openalex.org/W2164671256","https://openalex.org/W2169162266","https://openalex.org/W2169790726","https://openalex.org/W2170973713","https://openalex.org/W2172249054","https://openalex.org/W2323769589","https://openalex.org/W2473366480","https://openalex.org/W2517054293","https://openalex.org/W2552318961","https://openalex.org/W7140264777"],"related_works":["https://openalex.org/W2071575146","https://openalex.org/W2035486835","https://openalex.org/W2772984479","https://openalex.org/W2003579713","https://openalex.org/W6921047432","https://openalex.org/W2064476385","https://openalex.org/W2041576008","https://openalex.org/W2158455617","https://openalex.org/W2742259223","https://openalex.org/W7130246818"],"abstract_inverted_index":{"Zebrafish":[0],"is":[1],"an":[2,93],"emerging":[3],"and":[4,16,25,32,39,97,157,163,236,264,273,323],"promising":[5],"model":[6,312],"organism":[7],"to":[8,70,108,189,193,256,277,313],"study":[9,286,304,315],"cancer":[10],"formation,":[11,297],"organogenesis,":[12],"development,":[13],"cell":[14,29,133,187,320],"signaling,":[15],"drug":[17],"screening":[18],"applications.":[19],"Cellular":[20],"signaling":[21,316],"driven":[22],"by":[23,138],"E2F":[24,37,62,148],"TOR":[26,43,292],"proteins":[27],"regulate":[28],"proliferation,":[30,321],"growth":[31,322],"development;":[33],"yet":[34],"expression":[35,65,173,201,217],"of":[36,42,61,95,111,146,174,178,202,218,271],"targets":[38],"downstream":[40],"effectors":[41],"inhibition":[44],"have":[45],"not":[46],"been":[47],"studied":[48],"in":[49,51,66,68,78,104,118,131,180,196,205,209,216,253,265,269,293,301,319],"zebrafish":[50,67,80,102,162,210,251],"detail.":[52],"In":[53,250],"this":[54,221],"study,":[55],"we":[56,99,168],"first":[57],"demonstrated":[58,169],"the":[59,79,85,132,294],"conservation":[60],"target":[63,149],"ortholog":[64],"response":[69,145],"serum;":[71],"second":[72],"our":[73],"results":[74],"revealed":[75],"significant":[76,260],"changes":[77],"fibroblast":[81],"cells":[82,122,182,309],"(ZF4)":[83],"at":[84,128],"whole":[86],"transcriptome":[87],"level":[88],"upon":[89],"treatment":[90,199,245],"with":[91,183,226],"rapamycin,":[92],"inhibitor":[94],"TOR;":[96],"third":[98],"phenotypically":[100],"screened":[101],"embryos":[103],"vivo":[105,254],"when":[106],"exposed":[107],"different":[109],"doses":[110],"rapamycin.":[112],"Our":[113,207,285,303],"studies":[114,230],"showed":[115,142],"that":[116,143,170],"as":[117,238,310],"mammalian":[119,227],"cells,":[120],"ZF4":[121,181,308],"entered":[123],"into":[124],"a":[125,175,213,247,259,288,311],"quiescent":[126],"state":[127],"G1/S":[129],"phase":[130],"cycle,":[134],"which":[135],"was":[136],"reversed":[137],"serum":[139,144],"stimulation.":[140],"We":[141],"selected":[147],"gene":[150],"orthologs,":[151],"namely":[152],"pcna,":[153],"mybl2,":[154],"tyms,":[155],"mcm7":[156],"ctgf,":[158],"were":[159],"conserved":[160],"between":[161],"mammals.":[164],"Using":[165],"microarray":[166],"analysis,":[167],"rapamycin":[171,198,244,257],"modulated":[172],"large":[176],"number":[177],"genes":[179],"functions":[184],"ranging":[185],"from":[186,280],"cycle":[188],"protein":[190],"synthesis.":[191],"Similar":[192],"previous":[194],"findings":[195,208],"mammals,":[197],"downregulated":[200],"proteasomal":[203],"subunits":[204],"zebrafish.":[206,302],"also":[211,305],"implicated":[212],"moderate":[214],"increase":[215],"ribosomal":[219],"subunits;":[220],"finding":[222],"warrants":[223],"further":[224,314],"comparison":[225],"studies.":[228],"qRT-PCR":[229],"confirmed":[231],"dkk1b,":[232],"pah,":[233],"dcc,":[234],"cyp26b1":[235],"wif1":[237],"being":[239],"significantly":[240],"differentially":[241],"expressed":[242],"under":[243],"using":[246],"time-course":[248],"experiment.":[249],"embryos,":[252],"exposure":[255],"caused":[258],"dose-dependent":[261],"developmental":[262],"delay":[263],"particular":[266],"prominent":[267],"reductions":[268],"formation":[270],"pigments":[272],"cartilage,":[274],"tissues":[275],"known":[276],"be":[278],"derived":[279],"embryonic":[281],"neural":[282,295],"crest":[283,296],"cells.":[284],"implicates":[287],"potential":[289],"role":[290],"for":[291],"differentiation":[298],"or":[299],"migration":[300],"clearly":[306],"establish":[307],"pathways":[317],"involved":[318],"development.":[324]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
