{"id":"https://openalex.org/W2184938697","doi":"https://doi.org/10.1016/j.chroma.2015.07.037","title":"Development of an achiral supercritical fluid chromatography method with ultraviolet absorbance and mass spectrometric detection for impurity profiling of drug candidates. Part I: Optimization of mobile phase composition","display_name":"Development of an achiral supercritical fluid chromatography method with ultraviolet absorbance and mass spectrometric detection for impurity profiling of drug candidates. Part I: Optimization of mobile phase composition","publication_year":2015,"publication_date":"2015-07-13","ids":{"openalex":"https://openalex.org/W2184938697","doi":"https://doi.org/10.1016/j.chroma.2015.07.037","mag":"2184938697","pmid":"https://pubmed.ncbi.nlm.nih.gov/26195034"},"language":"en","primary_location":{"id":"doi:10.1016/j.chroma.2015.07.037","doi":"https://doi.org/10.1016/j.chroma.2015.07.037","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.chroma.2015.07.037","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079260157","display_name":"Elise Lemasson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elise Lemasson","raw_affiliation_strings":["Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041552166","display_name":"Sophie Bertin","orcid":"https://orcid.org/0000-0002-0074-9607","observed_orcids":["https://orcid.org/0000-0002-0074-9607"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Bertin","raw_affiliation_strings":["Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077344389","display_name":"Philippe Hennig","orcid":"https://orcid.org/0000-0002-1987-5646","observed_orcids":["https://orcid.org/0000-0002-1987-5646"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Hennig","raw_affiliation_strings":["Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048215675","display_name":"H\u00e9l\u00e8ne Boiteux","orcid":"https://orcid.org/0000-0002-1778-8266","observed_orcids":["https://orcid.org/0000-0002-1778-8266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Boiteux","raw_affiliation_strings":["Waters Corporation, 5 rue Jacques Monod, 78280 Guyancourt, France"],"raw_orcid":"https://orcid.org/0000-0002-1778-8266","affiliations":[{"raw_affiliation_string":"Waters Corporation, 5 rue Jacques Monod, 78280 Guyancourt, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004849300","display_name":"\u00c9ric Lesellier","orcid":"https://orcid.org/0000-0002-8816-0492","observed_orcids":["https://orcid.org/0000-0002-8816-0492"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Lesellier","raw_affiliation_strings":["Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054424329","display_name":"Caroline West","orcid":"https://orcid.org/0000-0001-7595-6777","observed_orcids":["https://orcid.org/0000-0001-7595-6777"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Caroline West","raw_affiliation_strings":["Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France. Electronic address: caroline.west@univ-orleans.fr","Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France"],"raw_orcid":"https://orcid.org/0000-0001-7595-6777","affiliations":[{"raw_affiliation_string":"Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France. Electronic address: caroline.west@univ-orleans.fr","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]},{"raw_affiliation_string":"Universit\u00e9 d'Orl\u00e9ans, Institut de Chimie Organique et Analytique (ICOA), CNRS UMR 7311, P\u00f4le de Chimie, rue de Chartres, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054424329"],"corresponding_institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":null,"fwci":5.9745,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.97584984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"1408","issue":null,"first_page":"217","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/supercritical-fluid-chromatography","display_name":"supercritical fluid chromatography","score":0.9179999828338623},{"id":"https://openalex.org/keywords/impurity-profiling","display_name":"impurity profiling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/drug-candidates","display_name":"drug candidates","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mobile-phase-additives","display_name":"mobile phase additives","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ammonium-acetate","display_name":"ammonium acetate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ammonium-hydroxide","display_name":"ammonium hydroxide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stationary-phase-selection","display_name":"stationary phase selection","score":0.5680000185966492},{"id":"https://openalex.org/keywords/derringer-desirability-function","display_name":"Derringer desirability function","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gradient-elution","display_name":"gradient elution","score":0.5860000252723694},{"id":"https://openalex.org/keywords/method-optimization","display_name":"method optimization","score":0.3709999918937683},{"id":"https://openalex.org/keywords/silica-support","display_name":"silica support","score":0.3449999988079071},{"id":"https://openalex.org/keywords/methanol-co-solvent","display_name":"methanol co-solvent","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9321783185005188},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8577080965042114},{"id":"https://openalex.org/C203147553","wikidata":"https://www.wikidata.org/wiki/Q332584","display_name":"Supercritical fluid chromatography","level":3,"score":0.6838957071304321},{"id":"https://openalex.org/C71987851","wikidata":"https://www.wikidata.org/wiki/Q7216430","display_name":"Impurity","level":2,"score":0.6034545302391052},{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.5951426029205322},{"id":"https://openalex.org/C118419359","wikidata":"https://www.wikidata.org/wiki/Q682585","display_name":"Supercritical fluid","level":2,"score":0.5063766241073608},{"id":"https://openalex.org/C2776798109","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet","level":2,"score":0.49880075454711914},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4506641626358032},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.39272138476371765},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.3463616371154785},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06277981400489807},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004340","descriptor_name":"Drug Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025924","descriptor_name":"Chromatography, Supercritical Fluid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.chroma.2015.07.037","doi":"https://doi.org/10.1016/j.chroma.2015.07.037","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.chroma.2015.07.037","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"pmid:26195034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26195034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1966102963","https://openalex.org/W1968098666","https://openalex.org/W1984390213","https://openalex.org/W1985323818","https://openalex.org/W1987572231","https://openalex.org/W1989471173","https://openalex.org/W2000013475","https://openalex.org/W2008782061","https://openalex.org/W2011238731","https://openalex.org/W2016442685","https://openalex.org/W2029505132","https://openalex.org/W2045667587","https://openalex.org/W2049630264","https://openalex.org/W2050553751","https://openalex.org/W2067755568","https://openalex.org/W2070424256","https://openalex.org/W2074900191","https://openalex.org/W2076545826","https://openalex.org/W2079623712","https://openalex.org/W2129751060","https://openalex.org/W2130618459"],"related_works":["https://openalex.org/W913526031","https://openalex.org/W2074900191","https://openalex.org/W2780855144","https://openalex.org/W2762809145","https://openalex.org/W1988729219","https://openalex.org/W2160306427","https://openalex.org/W2535102840","https://openalex.org/W2065902035","https://openalex.org/W1980944871","https://openalex.org/W2029538765"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}