{"id":"https://openalex.org/W2184919699","doi":null,"title":"The Global Hepatic Transcriptional Response of Male Fisher Rats to Dietary Aroclor 1254 Exposure","display_name":"The Global Hepatic Transcriptional Response of Male Fisher Rats to Dietary Aroclor 1254 Exposure","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2184919699","mag":"2184919699"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.wmich.edu:dissertations-1833","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.wmich.edu/dissertations/831","pdf_url":"https://scholarworks.wmich.edu/dissertations/831","source":{"id":"https://openalex.org/S4377196527","display_name":"ScholarWorks - WMU (Western Michigan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141649380","host_organization_name":"Western Michigan University","host_organization_lineage":["https://openalex.org/I141649380"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.wmich.edu/dissertations/831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022251385","display_name":"Trisha M. Basford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Trisha M. Basford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022251385"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aroclor-1254","display_name":"Aroclor 1254","score":0.9890000224113464},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dietary-exposure","display_name":"dietary exposure","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.9549999833106995},{"id":"https://openalex.org/keywords/liver-transcriptome","display_name":"liver transcriptome","score":0.7979999780654907},{"id":"https://openalex.org/keywords/subacute-exposure","display_name":"subacute exposure","score":0.6930000185966492},{"id":"https://openalex.org/keywords/subchronic-exposure","display_name":"subchronic exposure","score":0.9430000185966492},{"id":"https://openalex.org/keywords/exposure-duration","display_name":"exposure duration","score":0.6990000009536743},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.7369999885559082},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.699999988079071},{"id":"https://openalex.org/keywords/small-gtpase-signaling","display_name":"small GTPase signaling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.8169999718666077},{"id":"https://openalex.org/keywords/met","display_name":"MET","score":0.8040000200271606},{"id":"https://openalex.org/keywords/rab11a","display_name":"Rab11a","score":0.953000009059906},{"id":"https://openalex.org/keywords/fisher-rats","display_name":"Fisher rats","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.42417415976524353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39231979846954346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3865501880645752},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3628801107406616},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3337913751602173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28166258335113525}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.wmich.edu:dissertations-1833","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.wmich.edu/dissertations/831","pdf_url":"https://scholarworks.wmich.edu/dissertations/831","source":{"id":"https://openalex.org/S4377196527","display_name":"ScholarWorks - WMU (Western Michigan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141649380","host_organization_name":"Western Michigan University","host_organization_lineage":["https://openalex.org/I141649380"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},{"id":"mag:2184919699","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.wmich.edu/cgi/viewcontent.cgi?article=1833&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.wmich.edu:dissertations-1833","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.wmich.edu/dissertations/831","pdf_url":"https://scholarworks.wmich.edu/dissertations/831","source":{"id":"https://openalex.org/S4377196527","display_name":"ScholarWorks - WMU (Western Michigan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141649380","host_organization_name":"Western Michigan University","host_organization_lineage":["https://openalex.org/I141649380"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2184919699.pdf","grobid_xml":"https://content.openalex.org/works/W2184919699.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W20311902","https://openalex.org/W56957918","https://openalex.org/W145010144","https://openalex.org/W1487779296","https://openalex.org/W1497801799","https://openalex.org/W1507384014","https://openalex.org/W1532432516","https://openalex.org/W1563659068","https://openalex.org/W1628693640","https://openalex.org/W1696199194","https://openalex.org/W1786911182","https://openalex.org/W1838484704","https://openalex.org/W1875294959","https://openalex.org/W1964895626","https://openalex.org/W1966635260","https://openalex.org/W1966989001","https://openalex.org/W1967179667","https://openalex.org/W1968761316","https://openalex.org/W1970118868","https://openalex.org/W1971203821","https://openalex.org/W1972002682","https://openalex.org/W1974253904","https://openalex.org/W1976846448","https://openalex.org/W1977138379","https://openalex.org/W1977957456","https://openalex.org/W1980708125","https://openalex.org/W1984525361","https://openalex.org/W1985444988","https://openalex.org/W1986509703","https://openalex.org/W1987414296","https://openalex.org/W1989698144","https://openalex.org/W1991325701","https://openalex.org/W1992066987","https://openalex.org/W1993104325","https://openalex.org/W1996881038","https://openalex.org/W1997937449","https://openalex.org/W1999026128","https://openalex.org/W2000076586","https://openalex.org/W2001326655","https://openalex.org/W2001342889","https://openalex.org/W2002466608","https://openalex.org/W2002799332","https://openalex.org/W2003464391","https://openalex.org/W2004352153","https://openalex.org/W2005580407","https://openalex.org/W2009896818","https://openalex.org/W2011639873","https://openalex.org/W2011678217","https://openalex.org/W2012121526","https://openalex.org/W2012211548","https://openalex.org/W2016267605","https://openalex.org/W2017280548","https://openalex.org/W2017805288","https://openalex.org/W2017997169","https://openalex.org/W2024219755","https://openalex.org/W2024911097","https://openalex.org/W2025492442","https://openalex.org/W2025894136","https://openalex.org/W2028796178","https://openalex.org/W2030508628","https://openalex.org/W2032635061","https://openalex.org/W2033834901","https://openalex.org/W2038846465","https://openalex.org/W2042926174","https://openalex.org/W2044172471","https://openalex.org/W2044911368","https://openalex.org/W2045625866","https://openalex.org/W2045931107","https://openalex.org/W2048433180","https://openalex.org/W2049946453","https://openalex.org/W2050652978","https://openalex.org/W2050925466","https://openalex.org/W2051033404","https://openalex.org/W2051746949","https://openalex.org/W2052713990","https://openalex.org/W2053094488","https://openalex.org/W2054534506","https://openalex.org/W2062156204","https://openalex.org/W2062827640","https://openalex.org/W2062867109","https://openalex.org/W2070180569","https://openalex.org/W2070936807","https://openalex.org/W2073417234","https://openalex.org/W2082589589","https://openalex.org/W2082606221","https://openalex.org/W2083882115","https://openalex.org/W2086971054","https://openalex.org/W2086971483","https://openalex.org/W2087826013","https://openalex.org/W2088916380","https://openalex.org/W2089291803","https://openalex.org/W2093208156","https://openalex.org/W2093390692","https://openalex.org/W2095093689","https://openalex.org/W2099206288","https://openalex.org/W2099727427","https://openalex.org/W2099824652","https://openalex.org/W2100541220","https://openalex.org/W2100776437","https://openalex.org/W2101939270","https://openalex.org/W2104257008","https://openalex.org/W2107277218","https://openalex.org/W2107726313","https://openalex.org/W2108244474","https://openalex.org/W2109109397","https://openalex.org/W2110664610","https://openalex.org/W2110856690","https://openalex.org/W2111329465","https://openalex.org/W2111909451","https://openalex.org/W2113353518","https://openalex.org/W2113750680","https://openalex.org/W2116378614","https://openalex.org/W2116815663","https://openalex.org/W2122025963","https://openalex.org/W2122749842","https://openalex.org/W2125098787","https://openalex.org/W2125608517","https://openalex.org/W2130821715","https://openalex.org/W2133585947","https://openalex.org/W2133707700","https://openalex.org/W2136217316","https://openalex.org/W2137252935","https://openalex.org/W2139905874","https://openalex.org/W2139945563","https://openalex.org/W2140816112","https://openalex.org/W2146074529","https://openalex.org/W2152377123","https://openalex.org/W2152522761","https://openalex.org/W2155314738","https://openalex.org/W2157064056","https://openalex.org/W2157795344","https://openalex.org/W2158003822","https://openalex.org/W2165201727","https://openalex.org/W2167944618","https://openalex.org/W2170360953","https://openalex.org/W2222120260","https://openalex.org/W2253050644","https://openalex.org/W2255058389","https://openalex.org/W2321716269","https://openalex.org/W2405099207","https://openalex.org/W2461975442","https://openalex.org/W2488800968","https://openalex.org/W2490318366"],"related_works":["https://openalex.org/W1994059131","https://openalex.org/W2059810778","https://openalex.org/W2013494752","https://openalex.org/W2093837741","https://openalex.org/W2092352193","https://openalex.org/W2049604151","https://openalex.org/W2084129330","https://openalex.org/W2144060660","https://openalex.org/W1492507809","https://openalex.org/W1967864412"],"abstract_inverted_index":{"Dietary":[0],"intake":[1],"is":[2,24,60],"a":[3,20,27,315],"primary":[4],"route":[5],"for":[6,137,150,216,290,294,300],"biomagnification":[7],"of":[8,22,29,43,65,69,76,120,177,193,196,220,239,255,271],"environmentally":[9],"persistent":[10],"polychlorinated":[11],"biphenyls":[12],"(PCBs)":[13],"within":[14],"humans":[15],"and":[16,36,39,59,67,92,98,105,155,158,164,172,202,205,247,252,288,298,303,312],"animals.":[17],"Aroclor":[18],"1254,":[19],"mixture":[21],"PCBs,":[23,66],"associated":[25,71],"with":[26,72],"variety":[28],"toxic":[30],"responses":[31,46],"including":[32],"alterations":[33],"in":[34,83,113,185,188,199,209,237,242,269,282,310],"blood":[35],"lipid":[37],"biochemistry":[38],"tumor":[40],"promotion.":[41],"Measurement":[42],"the":[44,63,111,221],"transcriptional":[45,101],"to":[47,51,57,80,90,96,99,109,118,266,279,307],"low-level":[48],"dietary":[49,94],"exposure":[50,95,107],"A1254":[52],"has":[53],"not":[54],"been":[55],"reported":[56],"date,":[58],"important":[61,283],"given":[62],"persistence":[64],"range":[68],"effects":[70],"exposure.":[73,121],"The":[74],"aims":[75],"this":[77],"study":[78],"were":[79,124,145,160,187,207,234,264,305],"characterize":[81,110],"changes":[82,184,233,268,281,324],"rat":[84],"hepatic":[85],"global":[86],"gene":[87,114,173,322],"expression":[88,115,186,270,323],"due":[89,117],"sub-acute":[91,104],"sub-chronic":[93,106],"A1254,":[97,136],"compare":[100],"profiles":[102],"at":[103,167,226],"times":[108],"shift":[112],"profile":[116],"duration":[119],"Fisher":[122],"rats":[123,166],"fed":[125],"control":[126],"diet":[127,129],"or":[128,133,139],"containing":[130],"5.6":[131],"ppm":[132,135],"18":[134],"7":[138],"84":[140],"days.":[141],"Affymetrix":[142],"microarrays":[143],"(RGU34A)":[144],"prepared":[146],"from":[147],"liver":[148],"mRNA":[149],"each":[151,168],"treatment":[152],"group":[153],"(n=3)":[154],"time":[156],"point,":[157],"comparisons":[159],"made":[161],"between":[162],"controls":[163],"treated":[165,210],"time.":[169,228],"Class":[170],"comparison":[171],"ontology":[174],"(GO)":[175],"analysis":[176],"microarray":[178],"data":[179],"showed":[180],"that":[181,227],"most":[182],"significant":[183],"animals":[189,211],"consuming":[190],"high":[191],"doses":[192],"A1254.":[194],"Upregulation":[195],"genes":[197,240,273],"involved":[198,241],"sulfur":[200],"redox,":[201],"PCB":[203],"metabolism":[204],"detoxification":[206],"seen":[208],"after":[212],"1":[213],"week,":[214],"accounting":[215],"more":[217],"than":[218],"50%":[219],"significantly":[222,256],"changed":[223,257],"GO":[224,258,284],"categories":[225,285],"After":[229],"12":[230],"weeks":[231],"exposure,":[232],"also":[235],"observed":[236],"transcription":[238],"fatty":[243],"acid":[244],"(FA)":[245],"transport":[246],"metabolism,":[248,297],"small":[249],"GTPase-mediated":[250],"signaling,":[251],"transcription---approximately":[253],"40%":[254],"categories.":[259],"Quantitative":[260,319],"RT-PCR":[261],"Taqman":[262],"assays":[263],"used":[265],"verify":[267,308],"some":[272],"measured":[274,325],"by":[275,326],"microarray.":[276,327],"Genes":[277],"chosen":[278,306],"represent":[280],"include":[286],"Cd36":[287],"Met":[289],"FA-related":[291],"changes,":[292],"Cyp2b15":[293],"Phase":[295],"I":[296],"Rab11a":[299],"GTP-related.":[301],"Ca3":[302],"Hmgcs2":[304],"decreases":[309],"expression,":[311],"Ceacam10":[313],"as":[314],"unique,":[316],"AhR-responsive":[317],"gene.":[318],"PCR":[320],"confirmed":[321]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}