{"id":"https://openalex.org/W2184904480","doi":null,"title":"Osteoblastic cell attachment to hydroxyapatite-coated implant surfaces in vitro.","display_name":"Osteoblastic cell attachment to hydroxyapatite-coated implant surfaces in vitro.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2184904480","mag":"2184904480","pmid":"https://pubmed.ncbi.nlm.nih.gov/10212541"},"language":"en","primary_location":{"id":"pmid:10212541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10212541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of oral & maxillofacial implants","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113703127","display_name":"Yu Liang Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Y L Chang","raw_affiliation_strings":["School of Dentistry, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022721108","display_name":"Clark M. Stanford","orcid":"https://orcid.org/0000-0001-5449-1210","observed_orcids":["https://orcid.org/0000-0001-5449-1210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M Stanford","raw_affiliation_strings":["Bioengineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108418218","display_name":"James S. Wefel","orcid":"https://orcid.org/0000-0003-3584-023X","observed_orcids":["https://orcid.org/0000-0003-3584-023X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Wefel","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111865561","display_name":"John C. Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Keller","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4958,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.88381435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"2","first_page":"239","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyapatite-coating","display_name":"hydroxyapatite coating","score":0.9259999990463257},{"id":"https://openalex.org/keywords/osteoblast-adhesion","display_name":"osteoblast adhesion","score":0.800000011920929},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hydroxyapatite-crystallinity","display_name":"hydroxyapatite crystallinity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/surface-preparation","display_name":"surface preparation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/coating-dissolution","display_name":"coating dissolution","score":0.6150000095367432},{"id":"https://openalex.org/keywords/surface-topography","display_name":"surface topography","score":0.8700000047683716},{"id":"https://openalex.org/keywords/calcium-and-phosphate","display_name":"calcium and phosphate","score":0.5839999914169312},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C46275449","wikidata":"https://www.wikidata.org/wiki/Q2458815","display_name":"Crystallinity","level":2,"score":0.8873750567436218},{"id":"https://openalex.org/C506065880","wikidata":"https://www.wikidata.org/wiki/Q716","display_name":"Titanium","level":2,"score":0.5912443995475769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5715309381484985},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.5700174570083618},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.5644893646240234},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4830687344074249},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4821310043334961},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4556666910648346},{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.44057151675224304},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4170435667037964},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3813822269439697},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3740580081939697},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3200242817401886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09990108013153076},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09889256954193115},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.09636998176574707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07470831274986267},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10212541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10212541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of oral & maxillofacial implants","raw_type":"Journal Article"},{"id":"mag:2184904480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10212541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1990485571","https://openalex.org/W1997491556","https://openalex.org/W1997868095","https://openalex.org/W2013039163","https://openalex.org/W2015266821","https://openalex.org/W2030592102","https://openalex.org/W2032625729","https://openalex.org/W2036994913","https://openalex.org/W2045438670","https://openalex.org/W2046919954","https://openalex.org/W2058721292","https://openalex.org/W2075259322","https://openalex.org/W2092015310","https://openalex.org/W2094222302","https://openalex.org/W2103215318","https://openalex.org/W2108923529","https://openalex.org/W2143237072","https://openalex.org/W2143950663","https://openalex.org/W2158593785","https://openalex.org/W2166635785","https://openalex.org/W2240595894","https://openalex.org/W2344090145","https://openalex.org/W2404806970","https://openalex.org/W2409583769","https://openalex.org/W2411593623","https://openalex.org/W2414357166","https://openalex.org/W2917161007","https://openalex.org/W3025174573"],"related_works":["https://openalex.org/W2088935167","https://openalex.org/W2145508492","https://openalex.org/W2312239804","https://openalex.org/W2059113779","https://openalex.org/W2156869779","https://openalex.org/W2009178887","https://openalex.org/W2075795892","https://openalex.org/W2021646633","https://openalex.org/W2557664923","https://openalex.org/W3094490742"],"abstract_inverted_index":{"Hydroxyapatite":[0],"(HA)":[1],"used":[2],"as":[3,97],"a":[4,37],"coating":[5,23,165],"for":[6],"implants":[7],"can":[8],"exhibit":[9],"varying":[10],"levels":[11,115,120,143],"of":[12,20,31,72,85,116,121,162],"interaction":[13,43],"with":[14,44],"the":[15,21,29,40,45,57,100,110,113,163,169,181,187],"biologic":[16],"environment.":[17],"The":[18,177],"crystallinity":[19],"HA-based":[22],"has":[24],"been":[25],"shown":[26],"to":[27,35,55,60,99,191],"control":[28],"rate":[30],"dissolution":[32],"and":[33,62,69,77,93,141],"appears":[34],"play":[36],"role":[38],"in":[39,109,144,168],"initial":[41,188],"cellular":[42],"implant":[46],"surfaces.":[47,193],"An":[48],"osteoblastic":[49],"cell":[50,58,86,153,189],"attachment":[51,59,87,190],"assay":[52],"was":[53,89],"employed":[54],"examine":[56],"untreated":[61,92,131],"pretreated":[63,94,126],"(pH":[64,173],"5.2,":[65,174],"24":[66,175],"hours)":[67],"titanium":[68,101],"HA":[70,95,127,132,164,192],"coatings":[71],"low":[73],"(50%),":[74],"medium":[75,146],"(75%),":[76],"high":[78],"(90%)":[79],"crystallinity.":[80,117],"A":[81],"slightly":[82],"higher":[83,119],"percentage":[84],"(%CA)":[88],"found":[90,108],"on":[91,125,130,152],"surfaces":[96,128,133],"compared":[98],"surface.":[102],"No":[103],"significant":[104],"difference":[105],"could":[106],"be":[107],"%CA":[111,122],"between":[112],"3":[114],"However,":[118],"were":[123],"observed":[124],"than":[129],"(t":[134],"test,":[135],"P":[136],"<":[137],".05).":[138],"Elevated":[139],"calcium":[140],"phosphate":[142],"culture":[145],"did":[147],"not":[148],"have":[149],"any":[150],"effect":[151],"attachment.":[154],"Scanning":[155],"electron":[156],"microscopic":[157],"examinations":[158],"revealed":[159],"surface":[160,183],"degradation":[161],"following":[166],"pretreatment":[167],"simulated":[170],"inflammatory":[171],"media":[172],"hours).":[176],"results":[178],"suggest":[179],"that":[180],"altered":[182],"topography":[184],"may":[185],"influence":[186]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}