{"id":"https://openalex.org/W2184896499","doi":null,"title":"Hypoglycemia unawareness syndrome. Risk factors and treatment","display_name":"Hypoglycemia unawareness syndrome. Risk factors and treatment","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2184896499","mag":"2184896499"},"language":"en","primary_location":{"id":"mag:2184896499","doi":null,"is_oa":false,"landing_page_url":"https://www.sediabetes.org/gestor/upload/revistaAvances/25-4-4%20e.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018064279","display_name":"Francisco Javier Ampudia\u2010Blasco","orcid":"https://orcid.org/0000-0003-0221-0901","observed_orcids":["https://orcid.org/0000-0003-0221-0901"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Francisco Javier Ampudia\u2010Blasco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0221-0901","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018064279"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1977,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6434456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10508","display_name":"Patient Safety and Medication Errors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoglycemia-unawareness","display_name":"hypoglycemia unawareness","score":0.9639999866485596},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/neuroglycopenia","display_name":"neuroglycopenia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.5669999718666077},{"id":"https://openalex.org/keywords/counterregulatory-hormones","display_name":"counterregulatory hormones","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hypoglycemia-prevention","display_name":"hypoglycemia prevention","score":0.824999988079071},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/intensive-glycemic-control","display_name":"tight glycemic control","score":0.7960000038146973},{"id":"https://openalex.org/keywords/continuous-subcutaneous-insulin-infusion","display_name":"insulin pump therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insulin-analogs","display_name":"insulin analogues","score":0.996999979019165},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.9462398290634155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7379429340362549},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6138640642166138},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.599596381187439},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4639430046081543},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42796581983566284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41420888900756836},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3895801305770874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37871262431144714},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33927562832832336}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184896499","doi":null,"is_oa":false,"landing_page_url":"https://www.sediabetes.org/gestor/upload/revistaAvances/25-4-4%20e.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1931223844","https://openalex.org/W1946033027","https://openalex.org/W1964257289","https://openalex.org/W1973205654","https://openalex.org/W1974455520","https://openalex.org/W1991670137","https://openalex.org/W1992686377","https://openalex.org/W1998388840","https://openalex.org/W2004864567","https://openalex.org/W2008673024","https://openalex.org/W2010613471","https://openalex.org/W2013459424","https://openalex.org/W2036917835","https://openalex.org/W2067809855","https://openalex.org/W2068074025","https://openalex.org/W2070616275","https://openalex.org/W2074109861","https://openalex.org/W2075361652","https://openalex.org/W2079197462","https://openalex.org/W2092876947","https://openalex.org/W2109582726","https://openalex.org/W2112217619","https://openalex.org/W2113088354","https://openalex.org/W2120952370","https://openalex.org/W2138540710","https://openalex.org/W2144991899","https://openalex.org/W2145594694","https://openalex.org/W2147769512","https://openalex.org/W2160378554","https://openalex.org/W2165380524","https://openalex.org/W2165563030","https://openalex.org/W2167321173","https://openalex.org/W2169041612","https://openalex.org/W2177333643","https://openalex.org/W2186953567"],"related_works":["https://openalex.org/W2374165403","https://openalex.org/W3046631132","https://openalex.org/W2325811671","https://openalex.org/W4211014247","https://openalex.org/W2036917835","https://openalex.org/W4391646395","https://openalex.org/W4240758958","https://openalex.org/W2407779689","https://openalex.org/W2923586334","https://openalex.org/W1539583898"],"abstract_inverted_index":{"Hypoglycemia":[0,43],"unawareness":[1,44,63],"is":[2,31,45],"a":[3],"major":[4],"limiting":[5],"factor":[6],"in":[7,23,51,143],"the":[8,52],"management":[9],"of":[10,26,35,41,70,81,84,98,104,128],"type":[11,15],"1":[12],"and":[13,78],"advanced":[14],"2":[16],"diabetes.":[17],"This":[18],"common":[19],"problem,":[20],"which":[21],"occurs":[22],"about":[24],"25%":[25],"patients":[27],"treated":[28],"with":[29,48],"insulin,":[30],"characterized":[32],"by":[33],"loss":[34],"autonomic":[36],"warning":[37],"symptoms":[38],"before":[39],"development":[40],"neuroglycopenia.":[42],"also":[46],"associated":[47],"~7-fold":[49],"increase":[50],"risk":[53,59],"to":[54,88,113,140],"suffer":[55],"severe":[56],"hypoglycemia.":[57,82,105,115],"Several":[58],"factors":[60],"for":[61,93],"hypoglycemia":[62,89,94,99],"have":[64,110,137],"been":[65,111,138],"identified,":[66],"including":[67],"long":[68],"duration":[69],"diabetes,":[71],"tight":[72],"glycemic":[73],"control":[74],"(low":[75],"HbA1c":[76],"values),":[77],"repeated":[79],"episodes":[80],"Reduction":[83],"counterregulatory":[85],"hormone":[86],"responses":[87],"are":[90],"primarily":[91],"responsible":[92],"unawareness.":[95],"Strict":[96],"avoiding":[97],"restores":[100],"almost":[101],"completely":[102],"awareness":[103],"Therefore,":[106],"several":[107],"therapeutic":[108],"strategies":[109],"designed":[112],"prevent":[114],"Among":[116],"them,":[117],"evening":[118],"NPH":[119],"insulin":[120,124,129],"splitting,":[121],"continuous":[122,134],"subcutaneous":[123],"infusion,":[125],"preferential":[126],"use":[127],"analogues":[130],"and,":[131],"more":[132],"recently,":[133],"glucose":[135],"monitoring":[136],"proved":[139],"be":[141],"effective":[142],"most":[144],"cases.":[145]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
