{"id":"https://openalex.org/W2184875004","doi":"https://doi.org/10.23861/ejbm2006229","title":"The Pathogenesis of HIV-Associated Dementia: Recent Advances Using a SCID Mouse Model of HIV-Encephalitis","display_name":"The Pathogenesis of HIV-Associated Dementia: Recent Advances Using a SCID Mouse Model of HIV-Encephalitis","publication_year":2016,"publication_date":"2016-03-02","ids":{"openalex":"https://openalex.org/W2184875004","doi":"https://doi.org/10.23861/ejbm2006229","mag":"2184875004"},"language":"en","primary_location":{"id":"doi:10.23861/ejbm2006229","doi":"https://doi.org/10.23861/ejbm2006229","is_oa":true,"landing_page_url":"https://doi.org/10.23861/ejbm2006229","pdf_url":null,"source":{"id":"https://openalex.org/S2764736541","display_name":"Einstein Journal of Biology and Medicine","issn_l":"1559-5498","issn":["1559-5498","1559-5501"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Einstein Journal of Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.23861/ejbm2006229","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000408535","display_name":"Jennifer E. Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Cook","raw_affiliation_strings":["Department of Microbiology and Immunology#R##N#Medical University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology#R##N#Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058209103","display_name":"William R. Tyor","orcid":"https://orcid.org/0000-0002-0661-4842","observed_orcids":["https://orcid.org/0000-0002-0661-4842"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Tyor","raw_affiliation_strings":["Department of Microbiology and Immunology#R##N#Department of Neuroscience#R##N#Medical University of South Carolina#R##N##R##N#96 Jonathan Lucas Street #R##N#Chief, Neurology Service #R##N#Ralph H. Johnson VAMC#R##N#Charleston, SC 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology#R##N#Department of Neuroscience#R##N#Medical University of South Carolina#R##N##R##N#96 Jonathan Lucas Street #R##N#Chief, Neurology Service #R##N#Ralph H. Johnson VAMC#R##N#Charleston, SC 29425","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2301,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.665141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-dementia","display_name":"HIV-associated dementia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hiv-encephalitis","display_name":"HIV encephalitis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.718999981880188},{"id":"https://openalex.org/keywords/scid-mouse-model","display_name":"SCID mouse model","score":0.9829999804496765},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.4560000002384186},{"id":"https://openalex.org/keywords/virus-strains","display_name":"virus strains","score":0.5920000076293945},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.6209999918937683},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8331934213638306},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.7695767879486084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5815994739532471},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5772379636764526},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.5182135701179504},{"id":"https://openalex.org/C140933497","wikidata":"https://www.wikidata.org/wiki/Q7933606","display_name":"Viral pathogenesis","level":4,"score":0.5085440874099731},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4966791272163391},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41314879059791565},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.41202688217163086},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39072713255882263},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3017256259918213},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2890823185443878},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26811105012893677},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2677531838417053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07264989614486694}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23861/ejbm2006229","doi":"https://doi.org/10.23861/ejbm2006229","is_oa":true,"landing_page_url":"https://doi.org/10.23861/ejbm2006229","pdf_url":null,"source":{"id":"https://openalex.org/S2764736541","display_name":"Einstein Journal of Biology and Medicine","issn_l":"1559-5498","issn":["1559-5498","1559-5501"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Einstein Journal of Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.23861/ejbm2006229","doi":"https://doi.org/10.23861/ejbm2006229","is_oa":true,"landing_page_url":"https://doi.org/10.23861/ejbm2006229","pdf_url":null,"source":{"id":"https://openalex.org/S2764736541","display_name":"Einstein Journal of Biology and Medicine","issn_l":"1559-5498","issn":["1559-5498","1559-5501"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Einstein Journal of Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W101448748","https://openalex.org/W161653917","https://openalex.org/W197077816","https://openalex.org/W1042014336","https://openalex.org/W1481355729","https://openalex.org/W1576895063","https://openalex.org/W1613383360","https://openalex.org/W1965569942","https://openalex.org/W1973108297","https://openalex.org/W1980131626","https://openalex.org/W1986433721","https://openalex.org/W1990410878","https://openalex.org/W1991556620","https://openalex.org/W1992735212","https://openalex.org/W1993201898","https://openalex.org/W1996719502","https://openalex.org/W1999320884","https://openalex.org/W2000366874","https://openalex.org/W2000684605","https://openalex.org/W2008258216","https://openalex.org/W2008373701","https://openalex.org/W2011740000","https://openalex.org/W2018073475","https://openalex.org/W2028925744","https://openalex.org/W2029097526","https://openalex.org/W2031029696","https://openalex.org/W2043736935","https://openalex.org/W2044360533","https://openalex.org/W2045939131","https://openalex.org/W2048662892","https://openalex.org/W2049163289","https://openalex.org/W2061846866","https://openalex.org/W2062384458","https://openalex.org/W2064192790","https://openalex.org/W2068494868","https://openalex.org/W2071125722","https://openalex.org/W2077012020","https://openalex.org/W2077548100","https://openalex.org/W2077968305","https://openalex.org/W2078993207","https://openalex.org/W2080704165","https://openalex.org/W2092841915","https://openalex.org/W2093530590","https://openalex.org/W2096997912","https://openalex.org/W2097972613","https://openalex.org/W2106695034","https://openalex.org/W2113282092","https://openalex.org/W2114994968","https://openalex.org/W2119866405","https://openalex.org/W2120606210","https://openalex.org/W2131286622","https://openalex.org/W2132586158","https://openalex.org/W2133655326","https://openalex.org/W2133968571","https://openalex.org/W2138902434","https://openalex.org/W2142102457","https://openalex.org/W2143465147","https://openalex.org/W2144414931","https://openalex.org/W2149484912","https://openalex.org/W2149949545","https://openalex.org/W2150886578","https://openalex.org/W2158096469","https://openalex.org/W2159047279","https://openalex.org/W2164317596","https://openalex.org/W2167786748","https://openalex.org/W2169211575","https://openalex.org/W2311639754","https://openalex.org/W2314439984","https://openalex.org/W2315453370","https://openalex.org/W2316630134","https://openalex.org/W2339922662","https://openalex.org/W2415882964","https://openalex.org/W2416801520","https://openalex.org/W2417315706"],"related_works":["https://openalex.org/W2015354583","https://openalex.org/W126888180","https://openalex.org/W2004895789","https://openalex.org/W2048919465","https://openalex.org/W2085514277","https://openalex.org/W2149484912","https://openalex.org/W2026731803","https://openalex.org/W1576895063","https://openalex.org/W2145141193","https://openalex.org/W4388360272"],"abstract_inverted_index":{"In":[0],"the":[1,51,62,98,120,135,139,153,161],"era":[2],"of":[3,37,53,86,100,105,122,155,163],"highly":[4],"active":[5],"antiretroviral":[6],"therapy":[7],"(HAART)":[8],"there":[9,46],"has":[10],"been":[11],"a":[12,19,79,142],"decrease":[13],"in":[14,21,43,74,119,134,160],"AIDS":[15],"death":[16],"rates":[17],"and":[18,57,67,108,137,158],"reduction":[20],"HIV-related":[22],"neurological":[23],"complications.":[24],"However,":[25],"Human":[26,107],"Immunodeficiency":[27],"Virus-1":[28],"(HIV)-associated":[29],"dementia":[30],"(HAD)":[31],"still":[32,48],"affects":[33],"at":[34],"least":[35],"7%":[36],"HIV-positive":[38],"individuals.":[39],"Despite":[40],"significant":[41],"advances":[42],"HIV":[44],"research":[45,147],"are":[47,69],"questions":[49],"surrounding":[50],"pathogenesis":[52,121,162],"HAD.":[54,75,123,164],"Clinical":[55],"information":[56],"pathological":[58],"studies":[59,77,110],"suggest":[60,111],"that":[61,90,112,128],"frontal":[63],"cortex,":[64],"basal":[65],"ganglia,":[66],"hippocampus":[68],"important":[70,103,118],"neuroanatomical":[71],"areas":[72],"involved":[73],"Recent":[76],"utilizing":[78],"severe":[80],"combined":[81],"immunodeficiency":[82],"(SCID)":[83],"mouse":[84],"model":[85],"HIV-encephalitis":[87],"(HIVE)":[88],"indicate":[89],"central":[91],"nervous":[92],"system":[93],"(CNS)":[94],"viral":[95,113,156],"load":[96],"determines":[97],"severity":[99],"astrogliosis,":[101],"an":[102],"feature":[104],"HIVE.":[106],"animal":[109],"strains":[114],"may":[115],"also":[116],"be":[117],"A":[124],"recent":[125],"study":[126],"suggests":[127],"HAART":[129],"does":[130],"not":[131],"eradicate":[132],"virus":[133],"brain,":[136],"therefore,":[138],"CNS":[140],"is":[141],"reservoir":[143],"for":[144],"HIV.":[145],"Future":[146],"efforts":[148],"need":[149],"to":[150],"focus":[151],"on":[152],"role":[154],"strain":[157],"mutations":[159]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2016-06-24T00:00:00"}
