{"id":"https://openalex.org/W2184854458","doi":null,"title":"INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES (Int. J. of Pharm. Life Sci.) A Study on the Effect of High Glucose on Osteoblasts like Cell Proliferation and Apoptosis","display_name":"INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES (Int. J. of Pharm. Life Sci.) A Study on the Effect of High Glucose on Osteoblasts like Cell Proliferation and Apoptosis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2184854458","mag":"2184854458"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.ijplsjournal.com:article/523","doi":null,"is_oa":true,"landing_page_url":"https://ijplsjournal.com/index.php/ijpls/article/view/523","pdf_url":"https://ijplsjournal.com/index.php/ijpls/article/download/523/499","source":{"id":"https://openalex.org/S5407055365","display_name":"International Journal of Pharmacy and Life Sciences","issn_l":"0976-7126","issn":["0976-7126"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0976-7126","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ijplsjournal.com/index.php/ijpls/article/download/523/499","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Madhu Gupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhu Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113365546","display_name":"Vineeta Rawat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vineeta Rawat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112210543","display_name":"Arshad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arshad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.9610000252723694},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9359999895095825},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.699999988079071},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mg-63-cells","display_name":"MG-63 cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bone-cells","display_name":"bone cells","score":0.5569999814033508},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.7899037599563599},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6357660889625549},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5286527276039124},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5235148072242737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5221964716911316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5131307244300842},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4595242440700531},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4529343247413635},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.410075306892395},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3134581446647644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30680930614471436},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1733078956604004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12770825624465942},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10322806239128113}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ojs2.ijplsjournal.com:article/523","doi":null,"is_oa":true,"landing_page_url":"https://ijplsjournal.com/index.php/ijpls/article/view/523","pdf_url":"https://ijplsjournal.com/index.php/ijpls/article/download/523/499","source":{"id":"https://openalex.org/S5407055365","display_name":"International Journal of Pharmacy and Life Sciences","issn_l":"0976-7126","issn":["0976-7126"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0976-7126","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2184854458","doi":null,"is_oa":false,"landing_page_url":"http://www.ijplsjournal.com/issues%20PDF%20files/2014/September-2014/10.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs2.ijplsjournal.com:article/523","doi":null,"is_oa":true,"landing_page_url":"https://ijplsjournal.com/index.php/ijpls/article/view/523","pdf_url":"https://ijplsjournal.com/index.php/ijpls/article/download/523/499","source":{"id":"https://openalex.org/S5407055365","display_name":"International Journal of Pharmacy and Life Sciences","issn_l":"0976-7126","issn":["0976-7126"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0976-7126","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2184854458.pdf","grobid_xml":"https://content.openalex.org/works/W2184854458.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1965960323","https://openalex.org/W1971400919","https://openalex.org/W1972416013","https://openalex.org/W1976221277","https://openalex.org/W1983484286","https://openalex.org/W2009416961","https://openalex.org/W2015418035","https://openalex.org/W2047557527","https://openalex.org/W2053543161","https://openalex.org/W2056611129","https://openalex.org/W2082735845","https://openalex.org/W2100190098","https://openalex.org/W2109244454","https://openalex.org/W2116288435","https://openalex.org/W2119551577","https://openalex.org/W2142820105","https://openalex.org/W2153101639","https://openalex.org/W2155821999","https://openalex.org/W2328256573"],"related_works":["https://openalex.org/W7217873422","https://openalex.org/W2358123307","https://openalex.org/W2036431532","https://openalex.org/W2383135261","https://openalex.org/W3112162977","https://openalex.org/W2077021884","https://openalex.org/W2049467938","https://openalex.org/W2388693315","https://openalex.org/W2380709429","https://openalex.org/W2083163940"],"abstract_inverted_index":{"Incidences":[0],"of":[1,19,24,57,110],"diabetes":[2,25,132],"(both":[3],"type":[4,7],"I":[5],"and":[6,32,68,72,95,136],"II)":[8],"are":[9],"increasing":[10,134],"worldwide.":[11],"The":[12,107],"increased":[13],"blood":[14,41],"glucose":[15,42,58,87,111,127],"affects":[16],"the":[17],"functioning":[18],"all":[20],"tissues.":[21],"Various":[22],"complications":[23,31],"include":[26],"neuropathy,":[27],"nephropathy,":[28],"retinopathy,":[29],"micro-vascular":[30],"osteopathy.":[33],"It":[34,82],"is":[35,83],"now":[36],"becoming":[37],"clear":[38],"that":[39,85,126],"high":[40,86],"have":[43],"an":[44],"osmotic":[45],"effect":[46,56],"on":[47,59],"bone":[48,60],"cells.":[49],"To":[50],"know":[51],"what":[52],"would":[53],"be":[54],"likely":[55],"cells,":[61,100],"MTT":[62],"assay":[63],"for":[64,77],"cell":[65,105,138],"proliferation,":[66],"haematoxylin":[67],"eosin":[69],"double":[70,75],"staining":[71,76],"Hoechst-propidium":[73],"iodide":[74],"apoptosis":[78,94,135],"was":[79],"carried":[80],"out.":[81],"reported":[84],"induces":[88],"in":[89,98,131],"a":[90,101],"concentration":[91],"dependent":[92],"manner":[93],"inhibits":[96],"proliferation":[97],"MG-63":[99],"human":[102],"osteoblasts":[103],"like":[104],"line.":[106],"harmful":[108],"effects":[109],"were":[112,118],"found":[113],"reduced":[114],"when":[115],"these":[116],"cells":[117],"exposed":[119],"to":[120],"insulin.":[121],"Thus":[122],"our":[123],"study":[124],"suggests":[125],"may":[128],"induce":[129],"osteopenia":[130],"by":[133],"reducing":[137],"proliferation.":[139]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}