{"id":"https://openalex.org/W2184845795","doi":null,"title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphanates.","display_name":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphanates.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2184845795","mag":"2184845795","pmid":"https://pubmed.ncbi.nlm.nih.gov/21258276"},"language":"en","primary_location":{"id":"pmid:21258276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21258276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prilozi","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019484935","display_name":"Marica Pavkovic","orcid":"https://orcid.org/0000-0002-2692-5365","observed_orcids":["https://orcid.org/0000-0002-2692-5365"]},"institutions":[{"id":"https://openalex.org/I76245029","display_name":"Ss. Cyril and Methodius University in Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"M Pavkovic","raw_affiliation_strings":["Department of Haematology, Medical Faculty, Skopje, R. Macedonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Medical Faculty, Skopje, R. Macedonia","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041430778","display_name":"Gordana Petrushevska","orcid":"https://orcid.org/0000-0003-4502-5351","observed_orcids":["https://orcid.org/0000-0003-4502-5351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Petrushevska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041397826","display_name":"Rubens Jovanovi\u0107","orcid":"https://orcid.org/0000-0002-6574-9333","observed_orcids":["https://orcid.org/0000-0002-6574-9333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Jovanovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079273722","display_name":"\u041e\u043b\u0438\u0432\u0435\u0440 \u041a\u0430\u0440\u0430\u043d\u0444\u0438\u043b\u0441\u043a\u0438","orcid":"https://orcid.org/0000-0002-2807-4242","observed_orcids":["https://orcid.org/0000-0002-2807-4242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Karanfilski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112253645","display_name":"Lidija A. Cevreska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Cevreska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072633634","display_name":"Svetlana Stankovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Stankovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003277595","display_name":"Alexander Stojanovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Stojanovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4866,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66305926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"2","first_page":"39","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.9959999918937683},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":1.0},{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/zolendronate","display_name":"zolendronate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ibandronate","display_name":"ibandronate","score":0.8009999990463257},{"id":"https://openalex.org/keywords/clodronate","display_name":"clodronate","score":0.996999979019165},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6050000190734863},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tooth-extraction","display_name":"tooth extraction","score":0.5339999794960022},{"id":"https://openalex.org/keywords/osteoclast-inhibition","display_name":"osteoclast inhibition","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9526280164718628},{"id":"https://openalex.org/C2777556957","wikidata":"https://www.wikidata.org/wiki/Q2377991","display_name":"Osteonecrosis of the jaw","level":4,"score":0.910615861415863},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7047849893569946},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.661716878414154},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.6300642490386963},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5184178352355957},{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.5178556442260742},{"id":"https://openalex.org/C2779921893","wikidata":"https://www.wikidata.org/wiki/Q866622","display_name":"Bisphosphonate-associated osteonecrosis of the jaw","level":5,"score":0.492019385099411},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.42929643392562866},{"id":"https://openalex.org/C2779360543","wikidata":"https://www.wikidata.org/wiki/Q849893","display_name":"Dental extraction","level":2,"score":0.42858651280403137},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3890991806983948},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.3875459134578705},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38229209184646606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34259796142578125},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077268","descriptor_name":"Pamidronate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077557","descriptor_name":"Ibandronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059266","descriptor_name":"Bisphosphonate-Associated Osteonecrosis of the Jaw","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:21258276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21258276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prilozi","raw_type":"Case Reports"},{"id":"mag:3148404626","doi":null,"is_oa":false,"landing_page_url":"http://www.manu.edu.mk/prilozi/04pm.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2184845795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21258276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1965511198","https://openalex.org/W1990119475","https://openalex.org/W2030943688","https://openalex.org/W2088933781","https://openalex.org/W2105289281","https://openalex.org/W2107208293","https://openalex.org/W2116305785","https://openalex.org/W2122560580","https://openalex.org/W2132608007","https://openalex.org/W2134623104","https://openalex.org/W2137302084","https://openalex.org/W2141521877","https://openalex.org/W2143254775","https://openalex.org/W2144860907","https://openalex.org/W2146564095","https://openalex.org/W2160088903","https://openalex.org/W2164669124","https://openalex.org/W2166925007","https://openalex.org/W2168833892","https://openalex.org/W2400788153","https://openalex.org/W2415132941","https://openalex.org/W2415657570"],"related_works":["https://openalex.org/W2113821277","https://openalex.org/W2403451407","https://openalex.org/W7042127249","https://openalex.org/W2554545259","https://openalex.org/W2259028100","https://openalex.org/W3148404626","https://openalex.org/W2577947673","https://openalex.org/W2326319475","https://openalex.org/W2532408919","https://openalex.org/W2549230846"],"abstract_inverted_index":{"Bisphosphonates":[0],"are":[1],"pyrophosphate":[2],"analogues":[3],"which":[4,215],"inhibit":[5],"osteoclastic":[6],"activity.":[7],"Long":[8],"term":[9],"use":[10,212],"of":[11,19,58,66,74,122,127,153,161,170,182,187,192,201,213,230],"bisphosphonates":[12,54,82,131,193,231],"has":[13],"recently":[14],"been":[15],"associated":[16],"with":[17,48,78,81,118,130,148,167,235],"osteonecrosis":[18],"the":[20,31,56,72,84,94,109,210,217,238],"jaw":[21],"(ONJ)":[22],"defined":[23],"as":[24],"a":[25,38,180,226,243],"three":[26],"month":[27],"non-healing":[28],"defect":[29],"in":[30,45,76,88,105,108,124,203,233,246],"jaw.":[32],"ONJ":[33,75,123,202,241],"is":[34,216,242],"commonly":[35,137,219],"precipitated":[36],"by":[37,209,225],"tooth":[39],"extraction":[40],"or":[41,61,150,173],"other":[42],"stomatological":[43],"procedure":[44],"patients":[46,77,103,114,128,156,164,177,234],"treated":[47,80,117,129,147,166],"long-term,":[49],"potent,":[50],"high":[51],"dose":[52],"intravenous":[53],"for":[55],"management":[57],"myeloma,":[59],"breast":[60],"prostate":[62],"cancer.":[63],"The":[64,120,135,189,198],"aim":[65],"this":[67],"study":[68],"was":[69,132,140,195],"to":[70,92],"evaluate":[71],"incidence":[73,121,200],"MM":[79],"during":[83],"last":[85],"8":[86],"years":[87],"our":[89,106,125,204,247],"institution":[90,107,205],"and":[91,144,175,184,224],"pre-sent":[93],"first":[95],"two":[96,149],"cases.":[97],"We":[98],"have":[99],"analysed":[100],"247":[101],"myeloma":[102],"diagnosed":[104],"period":[110],"2002-09.":[111],"Only":[112],"190/247":[113],"(76.9%)":[115],"were":[116,146,165],"bisphosphonates.":[119,154,188],"group":[126],"2/190":[133],"(1%).":[134],"most":[136,218],"used":[138],"bisphosponate":[139],"i.v.":[141,168,185],"pamidronate":[142],"(17.8%)":[143],"46.6%":[145],"more":[151],"types":[152],"Sixty-five":[155],"(34.2%)":[157],"received":[158,179],"oral":[159,183],"forms":[160,169,186],"bisphosphonates;":[162],"42.1%":[163],"pamidronate,":[171],"ibondronate":[172],"clodronate,":[174],"45":[176],"(23.7%)":[178],"combination":[181],"mean":[190],"duration":[191,229],"therapy":[194],"24.7\u00b117.7":[196],"months.":[197],"low":[199],"could":[206],"be":[207,252],"explained":[208],"rare":[211,244],"zolendronate,":[214],"referred":[220],"bisphosphonate":[221],"causing":[222],"ONJ,":[223],"relatively":[227],"shorter":[228],"treatment":[232],"MM.":[236],"Despite":[237],"fact":[239],"that":[240],"complication":[245],"institution,":[248],"preventive":[249],"measures":[250],"must":[251],"considered.":[253]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}