{"id":"https://openalex.org/W2184746124","doi":null,"title":"Effect of tumor necrosis factor-\u03b1 on ventricular arrhythmias in rats with acute myocardial infarction in vivo.","display_name":"Effect of tumor necrosis factor-\u03b1 on ventricular arrhythmias in rats with acute myocardial infarction in vivo.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2184746124","mag":"2184746124","pmid":"https://pubmed.ncbi.nlm.nih.gov/25214942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129766"},"language":"en","primary_location":{"id":"pmid:25214942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25214942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of emergency medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4129766/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402004","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-1070-551X","observed_orcids":["https://orcid.org/0000-0002-1070-551X"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103244132","display_name":"Zhijian Chen","orcid":"https://orcid.org/0000-0002-2860-7950","observed_orcids":["https://orcid.org/0000-0002-2860-7950","https://orcid.org/0000-0002-9166-8246"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Jian Chen","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026170465","display_name":"Yuhua Liao","orcid":"https://orcid.org/0000-0001-6155-1576","observed_orcids":["https://orcid.org/0000-0001-6155-1576"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Hua Liao","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070412209","display_name":"Zhe Cao","orcid":"https://orcid.org/0000-0002-9379-2013","observed_orcids":["https://orcid.org/0000-0002-9379-2013","https://orcid.org/0000-0002-0196-1810"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Cao","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048305372","display_name":"Jia-ding Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Ding Xia","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101862292","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0001-7514-7937","observed_orcids":["https://orcid.org/0000-0001-7514-7937"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021111325","display_name":"Yimei Du","orcid":"https://orcid.org/0000-0003-1125-0294","observed_orcids":["https://orcid.org/0000-0003-1125-0294"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Mei Du","raw_affiliation_strings":["Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022 , China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.214,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59786225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"1","first_page":"53","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.20229999721050262,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.9589999914169312},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/programmed-electrical-stimulation","display_name":"programmed electrical stimulation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tnf-alpha-expression","display_name":"TNF-\u03b1 expression","score":0.7260000109672546},{"id":"https://openalex.org/keywords/left-anterior-descending-coronary-artery-ligation","display_name":"left anterior descending artery ligation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cardiomyocyte-inflammation","display_name":"cardiomyocyte inflammation","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9272774457931519},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.8259541988372803},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.8199468851089478},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7349842190742493},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6096421480178833},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5702523589134216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5404655933380127},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5172701478004456},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.5142516493797302},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.44598543643951416},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.42227452993392944},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.4128814935684204},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3307521343231201},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3233252167701721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:25214942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25214942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of emergency medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4129766","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4129766/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Emerg Med","raw_type":"Text"},{"id":"mag:2184746124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25214942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4129766","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4129766/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Emerg Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1963959424","https://openalex.org/W1980315300","https://openalex.org/W2059675239","https://openalex.org/W2069681479","https://openalex.org/W2072545342","https://openalex.org/W2073185052","https://openalex.org/W2127688157","https://openalex.org/W2142202377","https://openalex.org/W2148274682","https://openalex.org/W2150113001","https://openalex.org/W2159087408","https://openalex.org/W2159330910","https://openalex.org/W2168302554","https://openalex.org/W2369999586"],"related_works":["https://openalex.org/W3029698383","https://openalex.org/W2385447077","https://openalex.org/W2073185052","https://openalex.org/W2359429970","https://openalex.org/W2380531230","https://openalex.org/W2363112500","https://openalex.org/W2366797436","https://openalex.org/W3030930539","https://openalex.org/W7097379817","https://openalex.org/W1986559380"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1,61],"myocardial":[2,64],"infarction":[3,65],"(AMI)":[4],"is":[5],"an":[6,47],"acute":[7],"cardiovascular":[8],"emergency.":[9],"This":[10],"study":[11],"was":[12,66,83,95,224],"undertaken":[13],"to":[14,180,242],"assess":[15],"the":[16,69,74,89,140,143,184,202,205,229,243],"effect":[17],"of":[18,149,165,192,212,219,235,245],"tumor":[19,54],"necrosis":[20,55],"factor-\u03b1":[21],"(TNF-\u03b1)":[22],"on":[23],"ventricular":[24,115,196,220,246],"arrhythmias":[25,116,197,221],"induced":[26,111,195,237],"by":[27,72,156,238],"AMI":[28,48,70,185,203,239],"in":[29,31,68,88,183,228],"rats":[30,40],"vivo.":[32],"METHODS:":[33],"Two":[34],"hundred":[35],"and":[36,50,81,110,121,134,145,158,178,187,194,215],"forty":[37],"male":[38],"Wistar":[39],"were":[41,117,154,198],"randomized":[42],"into":[43],"a":[44,51,100,209,216],"sham-operation":[45,90,230],"group,":[46,49,204],"recombinant":[52],"human":[53],"factor":[56],"receptor:Fc":[57],"fusion":[58],"protein(rhTNFR:Fc)":[59],"group.":[60,91,189,231],"anterior":[62,76],"wall":[63],"produced":[67],"group":[71,94,186,207],"ligating":[73],"left":[75],"descending":[77],"coronary":[78],"artery":[79],"(LAD),":[80],"there":[82],"no":[84,225],"ligation":[85],"but":[86],"operation":[87],"The":[92,108,190,233],"rhTNFR:Fc":[93,188,206],"treated":[96],"with":[97,201],"rhTNFR:Fc(10":[98],"mg/kg),":[99],"TNF-\u03b1":[101,150,166,213,236],"antagonist,":[102],"24":[103],"hours":[104,133,136],"before":[105],"LAD":[106],"ligation.":[107,138],"spontaneous":[109,193],"programmed":[112],"electrical":[113],"stimulation":[114],"recorded":[118],"at":[119,175],"baseline":[120,181],"10":[122,170],"minutes,":[123,125,127,129,177],"20":[124],"30":[126],"60":[128],"3":[130],"hours,":[131],"6":[132],"12":[135],"after":[137,172],"At":[139],"same":[141],"time":[142],"protein":[144,214],"mRNA":[146],"expression":[147,211,234],"levels":[148],"among":[151],"different":[152],"groups":[153],"detected":[155],"histochemistry":[157],"real-time":[159],"fluorescent":[160],"quantitative":[161],"PCR.":[162],"RESULTS:":[163],"Expression":[164],"increased":[167],"markedly":[168],"from":[169],"minutes":[171],"infarction,":[173],"peaked":[174],"20-30":[176],"returned":[179],"gradually":[182],"time-windows":[191],"similar.":[199],"Compared":[200],"showed":[208],"lesser":[210],"lower":[217],"incidence":[218],"(P<0.05).":[222],"There":[223],"obvious":[226],"change":[227],"CONCLUSION:":[232],"could":[240],"contribute":[241],"onset":[244],"arrhythmias.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}