{"id":"https://openalex.org/W2184738849","doi":null,"title":"Niacin, an Old Drug, has New Effects on Central Nervous System Disease","display_name":"Niacin, an Old Drug, has New Effects on Central Nervous System Disease","publication_year":2010,"publication_date":"2010-12-24","ids":{"openalex":"https://openalex.org/W2184738849","mag":"2184738849"},"language":"en","primary_location":{"id":"mag:2184738849","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TODDISJ-2-181","pdf_url":null,"source":{"id":"https://openalex.org/S118055264","display_name":"The Open Drug Discovery Journal","issn_l":"1877-3818","issn":["1877-3818"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Drug Discovery Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005605929","display_name":"Jieli Chen","orcid":"https://orcid.org/0000-0001-5446-9101","observed_orcids":["https://orcid.org/0000-0001-5446-9101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jieli Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5446-9101","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005508444","display_name":"Michael Chopp","orcid":"https://orcid.org/0000-0002-1948-4493","observed_orcids":["https://orcid.org/0000-0002-1948-4493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chopp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1948-4493","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.23929781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neurorestoration","display_name":"neurorestoration","score":0.9179999828338623},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7120000123977661},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/arteriogenesis","display_name":"arteriogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neurobehavioral-recovery","display_name":"neurobehavioral recovery","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C2780092750","wikidata":"https://www.wikidata.org/wiki/Q134658","display_name":"Niacin","level":2,"score":0.8944185972213745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7535773515701294},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7492431402206421},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6333287358283997},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5643442273139954},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4897758960723877},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48605161905288696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3914850056171417},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38743749260902405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15946125984191895},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184738849","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TODDISJ-2-181","pdf_url":null,"source":{"id":"https://openalex.org/S118055264","display_name":"The Open Drug Discovery Journal","issn_l":"1877-3818","issn":["1877-3818"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Drug Discovery Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W45648871","https://openalex.org/W70616208","https://openalex.org/W111204299","https://openalex.org/W142256112","https://openalex.org/W184507775","https://openalex.org/W1514099358","https://openalex.org/W1950821376","https://openalex.org/W1963691526","https://openalex.org/W1963955553","https://openalex.org/W1964960841","https://openalex.org/W1965983458","https://openalex.org/W1966908204","https://openalex.org/W1967600226","https://openalex.org/W1969992151","https://openalex.org/W1974291607","https://openalex.org/W1974332277","https://openalex.org/W1975358173","https://openalex.org/W1975499948","https://openalex.org/W1975980495","https://openalex.org/W1982407680","https://openalex.org/W1988904536","https://openalex.org/W1993629125","https://openalex.org/W1995462251","https://openalex.org/W1996457468","https://openalex.org/W1997632745","https://openalex.org/W1998184104","https://openalex.org/W2001395360","https://openalex.org/W2004374443","https://openalex.org/W2008933430","https://openalex.org/W2012283308","https://openalex.org/W2012528824","https://openalex.org/W2017088706","https://openalex.org/W2017758662","https://openalex.org/W2019109313","https://openalex.org/W2023357335","https://openalex.org/W2028195118","https://openalex.org/W2029732548","https://openalex.org/W2034745336","https://openalex.org/W2036324226","https://openalex.org/W2036968137","https://openalex.org/W2039137711","https://openalex.org/W2040349094","https://openalex.org/W2043830871","https://openalex.org/W2048356493","https://openalex.org/W2054162051","https://openalex.org/W2057095219","https://openalex.org/W2064773695","https://openalex.org/W2067043657","https://openalex.org/W2070993413","https://openalex.org/W2073786918","https://openalex.org/W2075034523","https://openalex.org/W2075367810","https://openalex.org/W2077599940","https://openalex.org/W2078489774","https://openalex.org/W2079616833","https://openalex.org/W2082255083","https://openalex.org/W2083281877","https://openalex.org/W2083485745","https://openalex.org/W2083937132","https://openalex.org/W2084682411","https://openalex.org/W2087203034","https://openalex.org/W2087221897","https://openalex.org/W2089740883","https://openalex.org/W2091750609","https://openalex.org/W2094936415","https://openalex.org/W2099559324","https://openalex.org/W2101186431","https://openalex.org/W2104226967","https://openalex.org/W2104480184","https://openalex.org/W2115572248","https://openalex.org/W2120808705","https://openalex.org/W2121346841","https://openalex.org/W2121739004","https://openalex.org/W2123915935","https://openalex.org/W2125624222","https://openalex.org/W2129282529","https://openalex.org/W2129945276","https://openalex.org/W2133353133","https://openalex.org/W2135960771","https://openalex.org/W2136974107","https://openalex.org/W2138137064","https://openalex.org/W2139567444","https://openalex.org/W2145597104","https://openalex.org/W2147062889","https://openalex.org/W2147674804","https://openalex.org/W2150253311","https://openalex.org/W2153897714","https://openalex.org/W2155407519","https://openalex.org/W2156000283","https://openalex.org/W2160193200","https://openalex.org/W2160689800","https://openalex.org/W2162070885","https://openalex.org/W2166005447","https://openalex.org/W2167429331","https://openalex.org/W2326849545","https://openalex.org/W2335263401","https://openalex.org/W2411629462"],"related_works":["https://openalex.org/W1983603144","https://openalex.org/W4366603148","https://openalex.org/W3113086614","https://openalex.org/W2081232925","https://openalex.org/W2084330790","https://openalex.org/W2081203120","https://openalex.org/W2915556067","https://openalex.org/W2014711037","https://openalex.org/W2073034700","https://openalex.org/W2160479657"],"abstract_inverted_index":{"Increased":[0],"serum":[1,11],"cholesterol":[2,8,56,77],"and":[3,12,25,32,57,62,83,89,93,107,117,139],"decreased":[4],"high-density":[5],"lipoprotein":[6],"(HDL)":[7],"level":[9],"in":[10,34,49],"cerebro-spinal":[13],"fluid":[14],"is":[15,44,130],"a":[16,27,81],"risk":[17],"factor":[18],"for":[19,53],"the":[20,45,71,74,113],"development":[21],"of":[22,29,73,127],"Alzheimer":[23,137],"disease,":[24],"also":[26],"predictor":[28],"cardiovascular":[30],"events":[31],"stroke":[33,92,121],"epidemiologic":[35],"studies.":[36],"Niacin":[37],"(vitamin":[38],"B":[39],"3":[40],"or":[41],"nicotinic":[42],"acid)":[43],"most":[46],"effective":[47],"medication":[48],"current":[50],"clinical":[51],"use":[52],"increasing":[54,75],"HDL":[55,76],"it":[58],"substantially":[59],"lowers":[60],"triglycerides":[61],"LDL":[63],"cholesterol.":[64],"This":[65],"review":[66,129],"provides":[67],"an":[68],"update":[69],"on":[70,131,136],"role":[72],"agent,":[78],"niacin,":[79],"as":[80,103],"neuroprotective":[82,116],"neurorestorative":[84,118],"agent":[85],"which":[86],"promotes":[87],"angiogenesis":[88],"arteriogenesis":[90],"after":[91,120],"improves":[94],"neurobehavioral":[95],"recovery":[96],"following":[97],"central":[98],"nervous":[99],"system":[100],"diseases":[101],"such":[102],"stroke,":[104,132],"Alzheimer's":[105],"disease":[106,138],"multiple":[108,140],"sclerosis.":[109,141],"The":[110,124],"mechanisms":[111],"underlying":[112],"niacin":[114],"induced":[115],"effects":[119],"are":[122],"discussed.":[123],"primary":[125],"focus":[126],"this":[128],"with":[133],"shorter":[134],"discussion":[135]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}