{"id":"https://openalex.org/W2184734028","doi":null,"title":"A pilot study of conformal radiotherapy combined with erlotinib-based multimodality therapy in newly diagnosed metastatic non-small-cell lung cancer.","display_name":"A pilot study of conformal radiotherapy combined with erlotinib-based multimodality therapy in newly diagnosed metastatic non-small-cell lung cancer.","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2184734028","mag":"2184734028","pmid":"https://pubmed.ncbi.nlm.nih.gov/26044225"},"language":"en","primary_location":{"id":"pmid:26044225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26044225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091230191","display_name":"Longjiang Li","orcid":"https://orcid.org/0000-0003-1446-0692","observed_orcids":["https://orcid.org/0000-0003-1446-0692"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L Li","raw_affiliation_strings":["Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. chenlh5461@163.com","Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. chenlh5461@163.com","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110378566","display_name":"Liu Ly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L-Y Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049778932","display_name":"M Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048441575","display_name":"Xiao Nj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N-J Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057430380","display_name":"Zhang Yw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y-W Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079621137","display_name":"Y Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Q-Y Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q-Y Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102236426","display_name":"Li Qs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q-S Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052016146","display_name":"Dai Ym","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y-M Dai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056736359","display_name":"Min Yang","orcid":"https://orcid.org/0000-0001-6976-8526","observed_orcids":["https://orcid.org/0000-0001-6976-8526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008209723","display_name":"C Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000321255","display_name":"Chen Lh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L-H Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J Guan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Guan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.465,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68203599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"19","issue":"10","first_page":"1812","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.26460000872612,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-nsclc","display_name":"metastatic non-small cell lung cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/conformal-radiotherapy","display_name":"conformal radiotherapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8740000128746033},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7239999771118164},{"id":"https://openalex.org/keywords/number-of-metastases","display_name":"number of metastases","score":0.8700000047683716},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.9307361841201782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9124147295951843},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7049421072006226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6656177043914795},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.640349268913269},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5857691168785095},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46412184834480286},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.4427478015422821},{"id":"https://openalex.org/C2909325608","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib Hydrochloride","level":5,"score":0.4384019672870636},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4173528850078583},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3875782787799835},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3362359404563904},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.24585002660751343},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.1859135925769806}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:26044225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26044225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2184734028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26044225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1928659851","https://openalex.org/W1965754326","https://openalex.org/W1968280019","https://openalex.org/W2019667371","https://openalex.org/W2040604770","https://openalex.org/W2045291815","https://openalex.org/W2062664388","https://openalex.org/W2081483387","https://openalex.org/W2098341584","https://openalex.org/W2104357453","https://openalex.org/W2106585301","https://openalex.org/W2119248047","https://openalex.org/W2127685474","https://openalex.org/W2134122287","https://openalex.org/W2136043844","https://openalex.org/W2136066147","https://openalex.org/W2138297714","https://openalex.org/W2140617449","https://openalex.org/W2141454678","https://openalex.org/W2152755651","https://openalex.org/W2153891955","https://openalex.org/W2156354702","https://openalex.org/W2159911527","https://openalex.org/W2162994584","https://openalex.org/W2361702658"],"related_works":["https://openalex.org/W2353438750","https://openalex.org/W2383766202","https://openalex.org/W2351472378","https://openalex.org/W4410717758","https://openalex.org/W2292435599","https://openalex.org/W3030594100","https://openalex.org/W2591052740","https://openalex.org/W2109986616","https://openalex.org/W2177996735","https://openalex.org/W2414893629"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Lung":[1],"cancer":[2,44],"is":[3],"the":[4,11,23,256],"leading":[5],"cause":[6],"of":[7,25,29,73],"cancer-related":[8],"death":[9],"in":[10,14,17,38,131,159],"world,":[12],"particularly":[13],"major":[15],"cities":[16],"China.":[18],"We":[19],"aimed":[20],"to":[21,251],"determine":[22],"benefit":[24,254],"survival":[26,90,110,135,161,237],"and":[27,58,139],"toxicity":[28],"Conformal":[30],"Radiotherapy":[31],"(CRT)":[32],"combined":[33,243],"with":[34,56,60,70,104,113,128,140,191,201,221,231,244],"erlotinib-based":[35],"multimodality":[36],"therapy":[37,172],"newly":[39,232],"diagnosed":[40,50,233],"metastatic":[41,51,234],"non-small-cell":[42],"lung":[43],"(NSCLC).":[45],"PATIENTS":[46],"AND":[47],"METHODS:":[48],"Newly":[49],"NSCLC":[52,235],"patients":[53,67,94,112,137,200,230],"were":[54,95],"treated":[55],"CRT":[57,69],"erlotinib,":[59],"or":[61,170],"without":[62,138],"chemotherapy":[63],"matched":[64],"protocol.":[65],"The":[66,84,97],"received":[68],"a":[71,167],"dose":[72],"30-66":[74],"Gy.":[75],"Erlotinib":[76],"was":[77,88,100,155,164,241],"used":[78,165,242],"at":[79],"least":[80],"one":[81,106],"28-day":[82],"cycle.":[83],"primary":[85],"end":[86],"point":[87],"overall":[89],"(OS).":[91],"RESULTS:":[92],"Thirty-two":[93],"analyzed.":[96],"median":[98,160],"OS":[99,198],"517":[101],"days.":[102],"Patients":[103,127,190,218],"only":[105],"metastasis":[107,143],"showed":[108],"longer":[109,197],"than":[111,199],"multi-metastases":[114],"(986":[115],"vs.":[116,122,145,174,176,182,207,213],"380":[117],"days,":[118,147,178,209],"n":[119,179,210],"=":[120,125,152,180,188,211,216],"8":[121],"24,":[123],"p":[124,151,187,215],".009).":[126],"multiple":[129],"metastases":[130],"brain":[132,142],"conferred":[133],"worse":[134],"for":[136],"sole":[141],"(321":[144],"700":[146,175],"n=11":[148],"vs":[149,184],"21,":[150,214],".006).":[153],"There":[154],"no":[156],"significant":[157],"difference":[158],"whether":[162],"erlotinib":[163,240],"as":[166],"first-,":[168],"second-":[169],"third-line":[171],"(380":[173],"310":[177],"10":[181],"15":[183],"7,":[185],"respectively.":[186],".179).":[189],"TTCRT":[192,202],">":[193],"90":[194,204],"days":[195,205],"had":[196,236],"\u2264":[203],"(749":[206],"322":[208],"11":[212],".012).":[217],"tolerated":[219],"treatment":[220],"limited":[222],"Grade":[223],"1/2":[224],"toxicity.":[225],"CONCLUSIONS:":[226],"In":[227],"this":[228],"study,":[229],"benefits":[238],"when":[239],"CRT.":[245],"Further":[246],"prospective":[247],"trials":[248],"are":[249],"needed":[250],"derive":[252],"maximal":[253],"from":[255],"drug":[257],"treatment.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}