{"id":"https://openalex.org/W2184724045","doi":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","title":"Effects of altered tonicity by sodium chloride on l -tryptophan binding to hepatic nuclei","display_name":"Effects of altered tonicity by sodium chloride on l -tryptophan binding to hepatic nuclei","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2184724045","doi":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","mag":"2184724045","pmid":"https://pubmed.ncbi.nlm.nih.gov/10837352"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.2000.278.6.c1237","doi":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.2000.278.6.C1237","source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.2000.278.6.C1237","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069266016","display_name":"Herschel Sidransky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herschel Sidransky","raw_affiliation_strings":["Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","1 Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"1 Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110175032","display_name":"Ethel Verney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethel Verney","raw_affiliation_strings":["Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","1 Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"1 Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110915402","display_name":"Jan Marc Orenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Orenstein","raw_affiliation_strings":["Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","1 Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"1 Department of Pathology, George Washington University Medical Center, Washington, District of Columbia 20037","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":null,"apc_paid":null,"fwci":0.1203,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47012958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"278","issue":"6","first_page":"C1237","last_page":"C1245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.3441999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.3441999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.18150000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.12710000574588776,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.6980000138282776},{"id":"https://openalex.org/keywords/hypertonicity","display_name":"hypertonicity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hepatic-nuclei","display_name":"hepatic nuclei","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nuclear-envelope","display_name":"nuclear envelope","score":0.5709999799728394},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.8176208734512329},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7166889905929565},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7148706912994385},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.6538037061691284},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.6141694188117981},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.6011098027229309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5524885654449463},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.46153175830841064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45725932717323303},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39109569787979126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26496177911758423},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09764707088470459},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007038","descriptor_name":"Hypotonic Solutions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012462","descriptor_name":"Saline Solution, Hypertonic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.2000.278.6.c1237","doi":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.2000.278.6.C1237","source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:10837352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10837352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1152/ajpcell.2000.278.6.c1237","doi":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpcell.2000.278.6.c1237","pdf_url":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.2000.278.6.C1237","source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309515","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2184724045.pdf","grobid_xml":"https://content.openalex.org/works/W2184724045.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W75176711","https://openalex.org/W130600450","https://openalex.org/W183853873","https://openalex.org/W1498330369","https://openalex.org/W1502608526","https://openalex.org/W1503842068","https://openalex.org/W1523927419","https://openalex.org/W1565800162","https://openalex.org/W1590896008","https://openalex.org/W1775749144","https://openalex.org/W1816748024","https://openalex.org/W1906846423","https://openalex.org/W1975494014","https://openalex.org/W1984519956","https://openalex.org/W1984864591","https://openalex.org/W1987799155","https://openalex.org/W1988418570","https://openalex.org/W1991394663","https://openalex.org/W1996506930","https://openalex.org/W1999346625","https://openalex.org/W2005063559","https://openalex.org/W2005955865","https://openalex.org/W2010846706","https://openalex.org/W2012072821","https://openalex.org/W2013357778","https://openalex.org/W2031876856","https://openalex.org/W2035042033","https://openalex.org/W2040457846","https://openalex.org/W2047680935","https://openalex.org/W2059020692","https://openalex.org/W2063787926","https://openalex.org/W2085686895","https://openalex.org/W2085999431","https://openalex.org/W2103330925","https://openalex.org/W2115294533","https://openalex.org/W2210034751","https://openalex.org/W2286886009","https://openalex.org/W2323490739","https://openalex.org/W2336737725","https://openalex.org/W2398416118","https://openalex.org/W2406420848","https://openalex.org/W2412732574","https://openalex.org/W2412741412","https://openalex.org/W2417165835","https://openalex.org/W2798643531","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2110473992","https://openalex.org/W2060621321","https://openalex.org/W2163574134","https://openalex.org/W2054479717","https://openalex.org/W1979791357","https://openalex.org/W2082057249","https://openalex.org/W2050228427","https://openalex.org/W1969952101","https://openalex.org/W2060059667","https://openalex.org/W1973848278"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,246],"concerned":[3],"with":[4,69,102,115,178,182,199],"the":[5,157,214,220,225,234,250,257],"effects":[6,206,216],"of":[7,51,59,65,86,99,108,131,150,159,242],"NaCl":[8,31,71,104,132,164,185,235,243],"administered":[9,32],"in":[10,14,27,33,44,45,96,151,156,190,192,197,232,237,244,254],"vivo":[11,34,191,245],"or":[12,124],"added":[13,70,103,137,253],"vitro":[15,46,57,97,152,198,255],"to":[16,22,35,53,129,138,174,210,256],"isolated":[17,60,66,90,100,139,200,258],"nuclei":[18,25,101,140,202],"on":[19,207],"[(3)H]tryptophan":[20,52,87,109,154,180,208],"binding":[21,47,110,155,167,181,209],"rat":[23],"hepatic":[24,54,61,91,201,211,238,259],"assayed":[26],"vitro.":[28],"Hypertonic":[29],"(10.7%)":[30],"rats":[36,193],"caused":[37],"at":[38,73,126,169],"10":[39],"min":[40],"a":[41],"marked":[42],"decrease":[43],"(total":[48,111],"and":[49,78,112,172,194],"specific)":[50,113],"nuclei.":[55,212,260],"In":[56],"incubation":[58,98],"nuclei,":[62],"but":[63],"not":[64,142],"nuclear":[67,92,145,153,179],"envelopes,":[68],"(particularly":[72],"0.125":[74,160],"x":[75,80,161],"10(-4)":[76,81,162],"M":[77,163],"0.25":[79],"M)":[82],"revealed":[83,165,203],"significant":[84],"inhibition":[85,107],"binding.":[88,147],"However,":[89],"envelopes":[93],"prepared":[94],"after":[95,240],"did":[105,141],"show":[106],"compared":[114,177],"controls.":[116],"Other":[117],"salts":[118],"(KCl,":[119],"MgCl(2),":[120,135],"NaHCO(3),":[121],"NaC(2)H(3)O(2),":[122],"NaF,":[123],"Na(2)SO(4)),":[125],"similar":[127,218],"concentrations":[128],"that":[130,166,233],"except":[133],"for":[134,227],"when":[136],"appreciably":[143,247],"inhibit":[144],"tryptophan":[146],"Kinetic":[148],"studies":[149],"presence":[158],"decreased":[168],"0.5":[170],"h":[171,176],"continued":[173],"2":[175],"controls":[183],"(without":[184],"addition).":[186],"The":[187],"results":[188],"obtained":[189,196],"those":[195],"NaCl-induced":[204],"inhibitory":[205,215],"Although":[213],"were":[217],"under":[219],"two":[221],"different":[222,231],"experimental":[223],"conditions,":[224],"mechanism":[226],"each":[228],"may":[229],"be":[230],"concentration":[236],"cells":[239],"administration":[241],"higher":[248],"than":[249],"low":[251],"levels":[252]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
