{"id":"https://openalex.org/W2184708148","doi":null,"title":"Atypical toxicity associated with 5-Fluororacil in a DPD-deficient patient with pancreatic cancer. Is ethnicity a risk factor?","display_name":"Atypical toxicity associated with 5-Fluororacil in a DPD-deficient patient with pancreatic cancer. Is ethnicity a risk factor?","publication_year":2008,"publication_date":"2008-03-08","ids":{"openalex":"https://openalex.org/W2184708148","mag":"2184708148","pmid":"https://pubmed.ncbi.nlm.nih.gov/18326935"},"language":"en","primary_location":{"id":"pmid:18326935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18326935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110323346","display_name":"M. W. Saif","orcid":"https://orcid.org/0000-0001-8154-957X","observed_orcids":["https://orcid.org/0000-0001-8154-957X","https://orcid.org/0000-0003-0599-4991"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Wasif Saif","raw_affiliation_strings":["Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042559662","display_name":"Sandra Seller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Seller","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064038800","display_name":"Robert B. Diasio","orcid":"https://orcid.org/0000-0002-9648-9570","observed_orcids":["https://orcid.org/0000-0002-9648-9570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B Diasio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4169,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60167526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"9","issue":"2","first_page":"226","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dihydropyrimidine-dehydrogenase-deficiency","display_name":"dihydropyrimidine dehydrogenase deficiency","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.6769999861717224},{"id":"https://openalex.org/keywords/ethnicity","display_name":"ethnicity","score":0.492000013589859},{"id":"https://openalex.org/keywords/african-american-patients","display_name":"African American patients","score":0.9229999780654907},{"id":"https://openalex.org/keywords/fluoropyrimidine","display_name":"fluoropyrimidine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8684214353561401},{"id":"https://openalex.org/C2778050828","wikidata":"https://www.wikidata.org/wiki/Q1114455","display_name":"Dihydropyrimidine dehydrogenase","level":5,"score":0.6005432605743408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5662347078323364},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5531941652297974},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4760434627532959},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.46317559480667114},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4517951011657715},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4456935226917267},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4286549389362335},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.41903212666511536},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41822487115859985},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.2366037368774414},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.11325782537460327},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D054067","descriptor_name":"Dihydropyrimidine Dehydrogenase Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:18326935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18326935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W97873095","https://openalex.org/W1844681537","https://openalex.org/W1975080438","https://openalex.org/W1987628441","https://openalex.org/W2022932998","https://openalex.org/W2030601939","https://openalex.org/W2041956558","https://openalex.org/W2043327262","https://openalex.org/W2106633271","https://openalex.org/W2110984592","https://openalex.org/W2116815399","https://openalex.org/W2116957273","https://openalex.org/W2147329609","https://openalex.org/W2151824850","https://openalex.org/W2592249171","https://openalex.org/W2785266975"],"related_works":["https://openalex.org/W7100355581","https://openalex.org/W2116957273","https://openalex.org/W2056901624","https://openalex.org/W89882968","https://openalex.org/W2167341516","https://openalex.org/W2134094359","https://openalex.org/W2275059940","https://openalex.org/W1970055034","https://openalex.org/W4387751085","https://openalex.org/W202187616"],"abstract_inverted_index":{"CONTEXT:":[0],"Fluoropyrimidines":[1],"constitute":[2],"the":[3,81,87,111,117,128,177],"backbone":[4],"of":[5,47,70,97,130,134,148,179,199],"chemotherapy":[6],"regimens":[7],"for":[8],"GI":[9],"tumors,":[10],"including":[11],"pancreatic":[12,102],"cancer":[13,103],"where":[14],"it":[15],"is":[16,35,77],"used":[17],"either":[18],"as":[19,23,116,202],"a":[20,95,106],"radiosensitizer":[21],"or":[22],"second-line":[24],"after":[25],"failing":[26],"gemcitabine.":[27],"While":[28],"normal":[29],"dihydropyrimidine":[30],"dehydrogenase":[31],"(DPD)":[32],"enzyme":[33],"activity":[34,136],"rate":[36],"limiting":[37],"in":[38,80,86,187],"5-fluorouracil":[39],"(5-FU)":[40],"catabolism,":[41],"its":[42],"deficiency":[43,209],"could":[44],"increase":[45],"concentrations":[46],"bioavailable":[48],"5-FU":[49,54,123,168,183],"anabolic":[50],"products":[51],"leading":[52],"to":[53,127],"related":[55],"toxicity":[56,160],"syndrome.":[57],"The":[58,68],"most":[59],"common":[60,213],"toxicities":[61,180],"include":[62],"myelosuppression,":[63],"stomatitis,":[64],"neuropathy,":[65],"and":[66,84,114,164],"diarrhea.":[67],"prevalence":[69],"this":[71],"autosommal":[72],"codominently":[73],"inherited":[74],"pharmacogenetic":[75],"syndrome":[76],"approximately":[78],"3-5%":[79],"Caucasian":[82],"population":[83],"8%":[85],"African-American":[88,99],"population.":[89],"CASE":[90],"REPORT:":[91],"We":[92],"present":[93],"here":[94],"case":[96,174],"an":[98,144],"patient":[100],"with":[101,161,182,189],"who":[104],"developed":[105],"desquamative":[107],"skin":[108],"rash":[109,119],"on":[110],"face,":[112],"trunk,":[113],"forearms":[115],"worst":[118],"(grade":[120],"3)":[121],"following":[122],"bolus":[124],"that":[125,176,207],"led":[126],"investigation":[129],"DPD":[131,135,208],"enzyme.":[132],"Measurement":[133],"by":[137],"radioisotopic":[138],"assay":[139],"methods":[140],"described":[141],"previously":[142],"revealed":[143],"abnormally":[145],"low":[146],"level":[147],"0.087":[149],"nmol/min/mg":[150,155],"protein":[151],"(reference":[152],"range:":[153],"0.182-0.688":[154],"protein).":[156],"She":[157],"was":[158,170],"treated":[159],"intravenous":[162],"steroids":[163],"antihistamine":[165],"therapy.":[166],"Further":[167],"therapy":[169],"discontinued.":[171],"CONCLUSIONS:":[172],"This":[173],"suggest":[175],"pattern":[178],"associated":[181],"can":[184],"vary,":[185],"especially":[186],"patients":[188],"different":[190],"ethnic":[191],"backgrounds":[192],"(whites":[193],"versus":[194],"non-whites).":[195],"These":[196],"findings":[197],"become":[198],"further":[200],"importance":[201],"our":[203],"recent":[204],"study":[205],"suggests":[206],"may":[210],"be":[211],"more":[212],"among":[214],"African-Americans.":[215]},"counts_by_year":[{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}