{"id":"https://openalex.org/W2184695181","doi":"https://doi.org/10.23937/2377-3634/1410023","title":"An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study","display_name":"An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo-controlled Double-masked Pilot Study","publication_year":2015,"publication_date":"2015-02-28","ids":{"openalex":"https://openalex.org/W2184695181","doi":"https://doi.org/10.23937/2377-3634/1410023","mag":"2184695181"},"language":"en","primary_location":{"id":"doi:10.23937/2377-3634/1410023","doi":"https://doi.org/10.23937/2377-3634/1410023","is_oa":true,"landing_page_url":"https://doi.org/10.23937/2377-3634/1410023","pdf_url":null,"source":{"id":"https://openalex.org/S4210192899","display_name":"International Journal of Diabetes and Clinical Research","issn_l":"2377-3634","issn":["2377-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Clinical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.23937/2377-3634/1410023","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5327,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.66400086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase-inhibitors","display_name":"aldose reductase inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.6570000052452087},{"id":"https://openalex.org/keywords/antioxidant-formulation","display_name":"antioxidant formulation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lens-opacification","display_name":"lens opacification","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cataract-prevention","display_name":"cataract prevention","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sorbitol","display_name":"sorbitol","score":0.593999981880188},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.7789999842643738},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C2781085045","wikidata":"https://www.wikidata.org/wiki/Q7318308","display_name":"Reversing","level":2,"score":0.889150857925415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6428961157798767},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5911895036697388},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4785614311695099},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4324558973312378},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32426717877388},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20001402497291565},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11662155389785767},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10851240158081055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08460476994514465},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23937/2377-3634/1410023","doi":"https://doi.org/10.23937/2377-3634/1410023","is_oa":true,"landing_page_url":"https://doi.org/10.23937/2377-3634/1410023","pdf_url":null,"source":{"id":"https://openalex.org/S4210192899","display_name":"International Journal of Diabetes and Clinical Research","issn_l":"2377-3634","issn":["2377-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Clinical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.23937/2377-3634/1410023","doi":"https://doi.org/10.23937/2377-3634/1410023","is_oa":true,"landing_page_url":"https://doi.org/10.23937/2377-3634/1410023","pdf_url":null,"source":{"id":"https://openalex.org/S4210192899","display_name":"International Journal of Diabetes and Clinical Research","issn_l":"2377-3634","issn":["2377-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Clinical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W96015874","https://openalex.org/W126370443","https://openalex.org/W1500747637","https://openalex.org/W1553699181","https://openalex.org/W1965925231","https://openalex.org/W1971338384","https://openalex.org/W1975705439","https://openalex.org/W1995580618","https://openalex.org/W1998899890","https://openalex.org/W2011099368","https://openalex.org/W2015471544","https://openalex.org/W2026617399","https://openalex.org/W2035475671","https://openalex.org/W2037136678","https://openalex.org/W2037472087","https://openalex.org/W2060342381","https://openalex.org/W2061798884","https://openalex.org/W2064181963","https://openalex.org/W2073134613","https://openalex.org/W2078345953","https://openalex.org/W2080274260","https://openalex.org/W2083165373","https://openalex.org/W2084926467","https://openalex.org/W2090943274","https://openalex.org/W2113265909","https://openalex.org/W2134322200","https://openalex.org/W2140871020","https://openalex.org/W2150700975","https://openalex.org/W2160173879","https://openalex.org/W2163174380","https://openalex.org/W2170327657","https://openalex.org/W2410251140"],"related_works":["https://openalex.org/W2595442082","https://openalex.org/W2167947130","https://openalex.org/W2973454449","https://openalex.org/W2113265909","https://openalex.org/W4224529721","https://openalex.org/W2146270111","https://openalex.org/W2093648111","https://openalex.org/W2169913355","https://openalex.org/W2039115551","https://openalex.org/W209365777"],"abstract_inverted_index":{"Background:":[0],"The":[1,219],"majority":[2],"of":[3,15,38,61,84,105,121,175,188,197,293],"dogs":[4,177,190,200,258],"with":[5,22,75,155,234,259,268,285],"diabetes":[6,76,260],"mellitus":[7,77],"develop":[8],"blinding":[9,85],"mature":[10],"cataracts":[11,87],"through":[12],"the":[13,16,28,36,43,59,82,129,133,164,179,275,291],"action":[14,24],"enzyme":[17],"aldose":[18,44],"reductase":[19,45],"producing":[20],"sorbitol":[21],"osmotic":[23],"drawing":[25],"water":[26],"into":[27],"lens":[29,106,122,148,184],"thus":[30],"causing":[31],"opacification.":[32],"Here":[33],"we":[34],"evaluate":[35],"use":[37],"OcuGLO\u2122":[39,91,130],"a":[40,66,93,111,286],"formulation":[41],"including":[42],"inhibitor":[46],"alpha":[47],"lipoic":[48],"acid,":[49],"grapeseed":[50],"extract,":[51],"carotenoids,":[52],"omega-3-fatty":[53],"acids,":[54],"and":[55,72,102,126,132,158,281],"coenzyme":[56],"Q10":[57],"in":[58,65,147,163,253,257],"prevention":[60],"canine":[62],"diabetic":[63,86,230],"cataract":[64,231,255],"prospective":[67],"placebo-controlled":[68],"double-masked":[69],"study.":[70],"Materials":[71],"methods:":[73],"Dogs":[74,98],"but":[78,272],"as":[79,209],"yet":[80],"without":[81,145],"development":[83],"were":[88,99],"given":[89],"either":[90],"or":[92,216],"placebo":[94,134,165,180,280],"containing":[95],"antioxidant":[96],"vitamins.":[97],"examined":[100],"monthly":[101],"their":[103],"degree":[104],"opacification":[107,123,149,185],"documented":[108,125],"photographically":[109],"using":[110,136],"Genesis":[112],"D":[113],"fundus":[114],"camera":[115],"at":[116,172],"+10D.":[117],"Time":[118],"to":[119,212,265],"progression":[120],"was":[124,150,232],"compared":[127],"between":[128,279],"group":[131,166],"group,":[135,283],"Kaplan":[137],"Meier":[138],"survival":[139],"curve":[140],"statistics.":[141],"Results:":[142],"Mean":[143],"time":[144],"change":[146],"278":[151],"\u00b1":[152,160],"184":[153],"days":[154,162],"OcuGLO":[156,192,207],"Rx\u2122":[157,193,208,225,249],"77":[159],"40":[161],"this":[167,294],"difference":[168],"being":[169],"statistically":[170],"significant":[171,195],"p=0.0005.":[173],"Twelve":[174],"15":[176,189],"taking":[178,191],"developed":[181,194],"significantly":[182],"increased":[183],"while":[186],"5":[187],"cataract.":[196],"these":[198],"five":[199],"four":[201],"animals":[202],"did":[203],"not":[204],"receive":[205],"daily":[206],"directed":[210],"due":[211],"unrelated":[213],"concurrent":[214],"illness":[215],"owner":[217],"non-compliance.":[218],"remaining":[220],"dog":[221],"progressed":[222],"despite":[223],"Ocu-GLO":[224,238,248],"administration.":[226],"In":[227],"two":[228],"dogs,":[229],"reversed":[233],"regained":[235],"vision":[236],"on":[237],"Rx\u2122.":[239],"Discussion:":[240],"This":[241],"small":[242,287],"preliminary":[243],"study":[244,288],"demonstrates":[245,290],"that":[246,274],"oral":[247],"has":[250],"beneficial":[251],"effects":[252],"delaying":[254],"formation":[256],"mellitus.":[261],"We":[262],"look":[263],"forward":[264],"further":[266],"studies":[267],"larger":[269],"case":[270],"populations":[271],"note":[273],"statistical":[276],"significance":[277],"reached":[278],"supplement-treated":[282],"even":[284],"population,":[289],"efficacy":[292],"commercially":[295],"available":[296],"dietary":[297],"supplement.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
