{"id":"https://openalex.org/W2184669161","doi":null,"title":"Molecular Biotechnology Programme","display_name":"Molecular Biotechnology Programme","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2184669161","mag":"2184669161"},"language":"en","primary_location":{"id":"mag:2184669161","doi":null,"is_oa":false,"landing_page_url":"http://www.ibg.uu.se/digitalAssets/165/165169_3kongsholm-niclas-arbete.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056682122","display_name":"Niclas Kongsholm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Niclas Kongsholm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056682122"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cd127","display_name":"CD127","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":1.0},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.9559999704360962},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hardy-weinberg-disequilibrium","display_name":"Hardy-Weinberg disequilibrium","score":0.8619999885559082},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.9710000157356262},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6828216314315796},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6464680433273315},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6241751909255981},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5479370355606079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5230860710144043},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5082420706748962},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4364740252494812},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.42198047041893005},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4115343987941742},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3355103135108948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1976170837879181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11381879448890686}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184669161","doi":null,"is_oa":false,"landing_page_url":"http://www.ibg.uu.se/digitalAssets/165/165169_3kongsholm-niclas-arbete.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1545450626","https://openalex.org/W1987878615","https://openalex.org/W2019568999","https://openalex.org/W2029361834","https://openalex.org/W2039088602","https://openalex.org/W2050730569","https://openalex.org/W2056713533","https://openalex.org/W2085551183"],"related_works":["https://openalex.org/W1991697561","https://openalex.org/W2157718822","https://openalex.org/W2162800670","https://openalex.org/W3043726894","https://openalex.org/W6977263187","https://openalex.org/W2114619010","https://openalex.org/W2059208857","https://openalex.org/W2014686916","https://openalex.org/W3007078409","https://openalex.org/W1792998017"],"abstract_inverted_index":{"Three":[0],"candidate":[1],"genes":[2,31],"of":[3,51],"Multiple":[4],"Sclerosis;":[5],"IL7R,":[6],"LAG3":[7,62],"and":[8,32,49,59],"TIM3":[9],"have":[10],"been":[11],"analyzed":[12],"for":[13],"gene-gene":[14],"interactions":[15],"using":[16],"a":[17,64],"genotype-based":[18],"logistic":[19],"regression":[20],"model.":[21],"Our":[22],"results":[23],"suggest":[24],"two":[25],"interaction":[26,34],"effects":[27],"between":[28],"the":[29],"three":[30],"one":[33],"effect":[35],"within":[36,57],"TIM3.":[37],"Hardy-Weinberg":[38],"Disequilibrium":[39],"(HWD)":[40],"could":[41],"not":[42],"be":[43],"ruled":[44],"out":[45],"in":[46],"all":[47],"markers,":[48],"blocks":[50],"Linkage":[52],"Disequlibrium":[53],"(LD)":[54],"where":[55],"observed":[56],"IL7R":[58],"TIM3,":[60],"whereas":[61],"lacked":[63],"block":[65],"structured":[66],"LD":[67],"pattern.":[68]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}