{"id":"https://openalex.org/W2184637409","doi":"https://doi.org/10.1128/mcb.12.9.4123","title":"A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family.","display_name":"A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2184637409","doi":"https://doi.org/10.1128/mcb.12.9.4123","mag":"2184637409","pmid":"https://pubmed.ncbi.nlm.nih.gov/1508208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/360311"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.12.9.4123","doi":"https://doi.org/10.1128/mcb.12.9.4123","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.12.9.4123","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080940844","display_name":"Sarah M. Smolik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Smolik","raw_affiliation_strings":["Department of Molecular and Medical Genetics' and Vollum Institute for Advanced Biomedical Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics' and Vollum Institute for Advanced Biomedical Research,","institution_ids":["https://openalex.org/I2802707198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108477138","display_name":"R.E. Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Rose","raw_affiliation_strings":["Oregon Health Sciences University, Portland, Oregon 97201-3098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Portland, Oregon 97201-3098","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110639865","display_name":"Richard H. Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R H Goodman","raw_affiliation_strings":["Oregon Health Sciences University, Portland, Oregon 97201-3098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Portland, Oregon 97201-3098","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6612,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.67213055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"9","first_page":"4123","last_page":"4131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.2159000039100647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.13570000231266022,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucine-zipper-transcription-factors","display_name":"leucine zipper transcription factors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.6990000009536743},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.781000018119812},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.7559999823570251},{"id":"https://openalex.org/keywords/salivary-gland-development","display_name":"salivary gland development","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.7829999923706055},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8540836572647095},{"id":"https://openalex.org/C156860981","wikidata":"https://www.wikidata.org/wiki/Q2565229","display_name":"Leucine zipper","level":4,"score":0.831270694732666},{"id":"https://openalex.org/C157880135","wikidata":"https://www.wikidata.org/wiki/Q17832633","display_name":"ATF3","level":5,"score":0.7643375396728516},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6271607875823975},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.5508617162704468},{"id":"https://openalex.org/C19408993","wikidata":"https://www.wikidata.org/wiki/Q24784063","display_name":"bZIP domain","level":5,"score":0.5461276173591614},{"id":"https://openalex.org/C20291555","wikidata":"https://www.wikidata.org/wiki/Q4677462","display_name":"Activating transcription factor 2","level":5,"score":0.5456597805023193},{"id":"https://openalex.org/C199172495","wikidata":"https://www.wikidata.org/wiki/Q21116771","display_name":"CREB1","level":5,"score":0.5150672793388367},{"id":"https://openalex.org/C202908374","wikidata":"https://www.wikidata.org/wiki/Q4867030","display_name":"Basic helix-loop-helix leucine zipper transcription factors","level":5,"score":0.5022287368774414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4566156268119812},{"id":"https://openalex.org/C77179829","wikidata":"https://www.wikidata.org/wiki/Q4677459","display_name":"Activating transcription factor","level":4,"score":0.44710689783096313},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4227569103240967},{"id":"https://openalex.org/C196287685","wikidata":"https://www.wikidata.org/wiki/Q83138290","display_name":"POU domain","level":5,"score":0.4213995039463043},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4169582426548004},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.3795825242996216},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.31736183166503906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24337273836135864},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.22029229998588562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21282130479812622},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18753370642662048}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016350","descriptor_name":"Leucine Zippers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051699","descriptor_name":"Cyclic AMP Response Element-Binding Protein A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.12.9.4123","doi":"https://doi.org/10.1128/mcb.12.9.4123","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.12.9.4123","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:360311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:1508208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1508208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:360311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/360311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W20371925","https://openalex.org/W1495237614","https://openalex.org/W1533422392","https://openalex.org/W1756567331","https://openalex.org/W1973435759","https://openalex.org/W1975511017","https://openalex.org/W1976344568","https://openalex.org/W1986486427","https://openalex.org/W1988110468","https://openalex.org/W1990493528","https://openalex.org/W1994600118","https://openalex.org/W1996339709","https://openalex.org/W1998119535","https://openalex.org/W1999574349","https://openalex.org/W2000024512","https://openalex.org/W2000324336","https://openalex.org/W2002085601","https://openalex.org/W2008494281","https://openalex.org/W2014908429","https://openalex.org/W2017093132","https://openalex.org/W2017883686","https://openalex.org/W2023309134","https://openalex.org/W2028242823","https://openalex.org/W2033215389","https://openalex.org/W2037643106","https://openalex.org/W2042976701","https://openalex.org/W2044918611","https://openalex.org/W2047029758","https://openalex.org/W2051610691","https://openalex.org/W2051690744","https://openalex.org/W2059433193","https://openalex.org/W2064801441","https://openalex.org/W2071140879","https://openalex.org/W2073033206","https://openalex.org/W2076063939","https://openalex.org/W2077088537","https://openalex.org/W2081704409","https://openalex.org/W2084090566","https://openalex.org/W2090324348","https://openalex.org/W2091246553","https://openalex.org/W2093897768","https://openalex.org/W2097794242","https://openalex.org/W2100747076","https://openalex.org/W2109399660","https://openalex.org/W2121165949","https://openalex.org/W2129327954","https://openalex.org/W2135506398","https://openalex.org/W2143275370","https://openalex.org/W2144393631","https://openalex.org/W2144634347","https://openalex.org/W2167889770","https://openalex.org/W2314225431","https://openalex.org/W2728956820","https://openalex.org/W2764934547","https://openalex.org/W4236512674","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1996731338","https://openalex.org/W2148609464","https://openalex.org/W2122678951","https://openalex.org/W2213239053","https://openalex.org/W1495237614","https://openalex.org/W2153724035","https://openalex.org/W1981201346","https://openalex.org/W1979611100","https://openalex.org/W4236918960","https://openalex.org/W2076989376"],"abstract_inverted_index":{"In":[0,103,144],"this":[1,37,74],"report,":[2],"we":[3],"describe":[4],"the":[5,18,43,62,67,90,109,122,128,142,150,163,175],"isolation":[6],"and":[7,24,97,130,137,155,168,184],"initial":[8],"characterization":[9],"of":[10,27,42,47,76,99,117,141],"a":[11,40],"Drosophila":[12],"protein,":[13],"dCREB-A,":[14],"that":[15,36,54,174],"can":[16],"bind":[17],"somatostatin":[19],"cyclic":[20],"AMP":[21],"(cAMP)-responsive":[22],"element":[23,101],"is":[25,39,51,81,106,119,147,160],"capable":[26],"activating":[28],"transcription":[29,48,177],"in":[30,53,61,73,93,108,121,127,149,156,162,182],"cell":[31,133],"culture.":[32],"Sequence":[33],"analysis":[34],"demonstrates":[35],"protein":[38],"member":[41],"leucine":[44],"zipper":[45,63],"family":[46],"factors.":[49],"dCREB-A":[50,105,146,158,176],"unusual":[52],"it":[55],"contains":[56],"six":[57],"hydrophobic":[58],"residue":[59],"iterations":[60],"domain":[64,80],"rather":[65],"than":[66,88],"four":[68],"or":[69],"five":[70],"commonly":[71],"found":[72,126],"group":[75],"proteins.":[77],"The":[78],"DNA-binding":[79],"more":[82,114],"closely":[83],"related":[84],"to":[85,89],"mammalian":[86],"CREB":[87],"AP-1":[91],"factors":[92],"both":[94],"sequence":[95],"homology":[96],"specificity":[98],"cAMP-responsive":[100],"binding.":[102],"embryos,":[104],"expressed":[107,148],"developing":[110],"salivary":[111,135],"gland.":[112],"A":[113],"complex":[115],"pattern":[116],"expression":[118],"detected":[120],"adult;":[123],"transcripts":[124],"are":[125],"brain":[129],"optic":[131],"lobe":[132],"bodies,":[134],"gland,":[136],"midgut":[138],"epithelial":[139],"cells":[140],"cardia.":[143],"females,":[145],"ovarian":[151],"columnar":[152],"follicle":[153],"cells,":[154],"males,":[157],"RNA":[159],"seen":[161],"seminal":[164],"vesicle,":[165],"ejaculatory":[166,169],"duct,":[167],"bulb.":[170],"These":[171],"results":[172],"suggest":[173],"factor":[178],"may":[179],"be":[180],"involved":[181],"fertility":[183],"neurological":[185],"functions.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
