{"id":"https://openalex.org/W2184637005","doi":null,"title":"Hip\u00f3tese oxidativa da hipertens\u00e3o arterial: uma minirrevis\u00e3o Oxidative hypothesis of hypertension: a mini-review","display_name":"Hip\u00f3tese oxidativa da hipertens\u00e3o arterial: uma minirrevis\u00e3o Oxidative hypothesis of hypertension: a mini-review","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2184637005","mag":"2184637005"},"language":"pt","primary_location":{"id":"mag:2184637005","doi":null,"is_oa":false,"landing_page_url":"http://departamentos.cardiol.br/dha/revista/14-4/12-oxidativa.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104689674","display_name":"Sandra Mary Lima Vasconcelos","orcid":"https://orcid.org/0000-0002-9438-3537","observed_orcids":["https://orcid.org/0000-0002-9438-3537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Mary Lima Vasconcelos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017573214","display_name":"Mar\u00edlia Oliveira Fonseca Goulart","orcid":"https://orcid.org/0000-0001-9860-3667","observed_orcids":["https://orcid.org/0000-0001-9860-3667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00edlia Oliveira Fonseca Goulart","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9860-3667","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082689831","display_name":"Maria Alayde Mendon\u00e7a da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Alayde Mendon\u00e7a da Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061676994","display_name":"Annelise Costa Machado Gomes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annelise Costa Machado Gomes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02419355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8059999942779541},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9340000152587891},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7900000214576721},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.9639999866485596},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"lipoxygenase","score":0.972000002861023},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.8761535882949829},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7603795528411865},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.6993378400802612},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6942682266235352},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6657983660697937},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6377050280570984},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5508850812911987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4746421277523041},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.45434755086898804},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.44744592905044556},{"id":"https://openalex.org/C2781252958","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NAD(P)H oxidase","level":4,"score":0.44215163588523865},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4178566634654999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3564116656780243},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34548234939575195},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.3397694230079651},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3238331079483032},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.24823683500289917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16452878713607788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.156241774559021},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184637005","doi":null,"is_oa":false,"landing_page_url":"http://departamentos.cardiol.br/dha/revista/14-4/12-oxidativa.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1967729440","https://openalex.org/W1974739160","https://openalex.org/W1975781920","https://openalex.org/W1976555160","https://openalex.org/W1979491078","https://openalex.org/W1980010223","https://openalex.org/W1991956478","https://openalex.org/W1993952575","https://openalex.org/W2004804839","https://openalex.org/W2031733630","https://openalex.org/W2038709676","https://openalex.org/W2062786004","https://openalex.org/W2066050507","https://openalex.org/W2070796816","https://openalex.org/W2085137779","https://openalex.org/W2099273954","https://openalex.org/W2107946375","https://openalex.org/W2131410124","https://openalex.org/W2132243058","https://openalex.org/W2135519224","https://openalex.org/W2144471895","https://openalex.org/W2146248018","https://openalex.org/W2148637873","https://openalex.org/W2156121263","https://openalex.org/W2159227424","https://openalex.org/W2162668251","https://openalex.org/W2169466315","https://openalex.org/W2332686462","https://openalex.org/W2397681785","https://openalex.org/W2414167269","https://openalex.org/W2564319720","https://openalex.org/W2916079865","https://openalex.org/W3015986900","https://openalex.org/W3153213718","https://openalex.org/W3164891998","https://openalex.org/W3169156149"],"related_works":["https://openalex.org/W2032832927","https://openalex.org/W2004804839","https://openalex.org/W2411159902","https://openalex.org/W1827761626","https://openalex.org/W171028678","https://openalex.org/W2077281334","https://openalex.org/W2947293374","https://openalex.org/W2564750015","https://openalex.org/W7098948659","https://openalex.org/W2022065323"],"abstract_inverted_index":{"Systemic":[0],"Arterial":[1],"Hypertension":[2],"(HAS)":[3],"is":[4,127,135],"a":[5,128],"condition":[6],"charac-":[7],"terized":[8],"by":[9,21,212],"endothelial":[10,154,185],"dysfunction,":[11],"which":[12,42,91,106],"main":[13],"role":[14],"consists":[15],"on":[16,77],"stopping":[17],"the":[18,22,26,33,39,44,50,58,64,68,78,95,98,108,111,115,139,147,150,192,203],"vase-relaxation":[19],"caused":[20],"decreased":[23],"bioactivity":[24],"of":[25,47,67,71,97,110,149,156,194,202],"nitric":[27,183],"oxide":[28,184],"(NO":[29],"\u2022":[30,104,143],")":[31],"in":[32,54,94],"vascular":[34,209],"wall,":[35],"due,":[36],"equally,":[37],"to":[38,114,121,137],"oxidative":[40,45,51,89],"stress,":[41],"represents":[43],"hypothesis":[46],"hypertension.":[48],"Conceptually,":[49],"stress":[52,90,201],"results":[53,93],"an":[55],"unbalance":[56],"between":[57,118],"antioxidant":[59],"and":[60,74,81,158,182,189,208],"pro-oxidant":[61],"systems,":[62],"making":[63],"harmful":[65,130],"action":[66],"reactive":[69,131],"species":[70],"oxygen":[72],"(ROS)":[73],"nitrogen":[75],"prevail":[76],"cells,":[79],"tissues":[80],"vital":[82],"organs.":[83],"This":[84],"article":[85],"presents,":[86],"concisely,":[87],"HASendothelial":[88],"mainly":[92],"overproduction":[96,155],"superoxide":[99],"radical":[100,141],"anion":[101],"(O":[102],"2":[103],"\u00af),":[105],"inhibits":[107],"activity":[109],"NOdue,":[112],"mainly,":[113],"direct":[116],"reaction":[117],"these":[119],"two":[120],"create":[122],"peroxynitrite":[123],"(ONOO\u00af).":[124],"Peroxynitrite":[125],"(ONOO\u00af)":[126],"particularly":[129],"intermediate,":[132],"as":[133],"it":[134],"able":[136],"generate":[138],"hydroxyl":[140],"(":[142],"OH)":[144],"even":[145],"without":[146,191],"presence":[148],"transition":[151],"metal.":[152],"The":[153],"ROS":[157],"RNS":[159],"occurs":[160],"(1)":[161],"through":[162,197],"enzymatic":[163],"reactions":[164],"(NAD(P)H":[165],"oxidase":[166,172],"-":[167,173,176,180,187],"NAD(P)":[168],"Hox":[169],",":[170],"xanthine":[171],"XO,":[174],"lipo-oxygenase":[175],"LOx,":[177],"ciclo-":[178],"oxygenase":[179],"COx,":[181],"synthase":[186],"(eNOS))":[188],"(2)":[190],"participation":[193],"enzymes":[195],"but":[196],"mechanical":[198],"forces":[199],"(shear":[200],"tur-":[204],"bulent":[205],"blood":[206],"flux":[207],"stretch":[210],"determined":[211],"luminal":[213],"pressure).":[214]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}