{"id":"https://openalex.org/W2184616672","doi":null,"title":"Measurement of receptor concentration and forward-binding rate constant via radiopharmacokinetic modeling of technetium-99m-galactosyl-neoglycoalbumin.","display_name":"Measurement of receptor concentration and forward-binding rate constant via radiopharmacokinetic modeling of technetium-99m-galactosyl-neoglycoalbumin.","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2184616672","mag":"2184616672","pmid":"https://pubmed.ncbi.nlm.nih.gov/2045930"},"language":"en","primary_location":{"id":"pmid:2045930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2045930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043166346","display_name":"David R. Vera","orcid":"https://orcid.org/0000-0001-8253-1099","observed_orcids":["https://orcid.org/0000-0001-8253-1099"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Vera","raw_affiliation_strings":["Department of Radiology, University of California, Davis, Sacramento 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of California, Davis, Sacramento 95817","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109899834","display_name":"Robert C. Stadalnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R C Stadalnik","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076553701","display_name":"Walter L. Trudeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W L Trudeau","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063317387","display_name":"Paul O. Scheibe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P O Scheibe","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109093605","display_name":"Kenneth A. Krohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K A Krohn","raw_affiliation_strings":["University Of California at Davis#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of California at Davis#TAB#","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":8.4659,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.97862567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"6","first_page":"1169","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-concentration","display_name":"receptor concentration","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hepatic-plasma-flow","display_name":"hepatic plasma flow","score":0.9010000228881836},{"id":"https://openalex.org/keywords/liver-scintigraphy","display_name":"liver scintigraphy","score":0.6299999952316284},{"id":"https://openalex.org/keywords/receptor-ligand-binding-kinetics","display_name":"receptor-ligand binding kinetics","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7555272579193115},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.6839297413825989},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6713728904724121},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.505561113357544},{"id":"https://openalex.org/C2908944559","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Distribution Volume","level":4,"score":0.4671696126461029},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4648524522781372},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.445607990026474},{"id":"https://openalex.org/C93391505","wikidata":"https://www.wikidata.org/wiki/Q658700","display_name":"Reaction rate constant","level":3,"score":0.4360368251800537},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4219841957092285},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.3506365418434143},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.28313350677490234},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2448495328426361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20396646857261658},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19499188661575317},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.11416620016098022},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037263","descriptor_name":"Asialoglycoprotein Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2045930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2045930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:2184616672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2045930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1364894146","display_name":"Molecular Imaging of Cancer and Its Response to Therapy","funder_award_id":"P01CA042045","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3646098654","display_name":"TC99M-NEOGALACTOALBUMIN EVALUATION OF LIVER DISEASE","funder_award_id":"1r01am034706-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W50135966","https://openalex.org/W1893058155","https://openalex.org/W1954463628","https://openalex.org/W1966837555","https://openalex.org/W1995343285","https://openalex.org/W1997485587","https://openalex.org/W2031903860","https://openalex.org/W2038663356","https://openalex.org/W2096998012","https://openalex.org/W2121887890","https://openalex.org/W2163481415","https://openalex.org/W2171074980","https://openalex.org/W2181443686","https://openalex.org/W2437755074"],"related_works":["https://openalex.org/W2077946552","https://openalex.org/W2181443686","https://openalex.org/W322337358","https://openalex.org/W48522681","https://openalex.org/W2163481415","https://openalex.org/W1995343285","https://openalex.org/W2159420827","https://openalex.org/W1893058155","https://openalex.org/W1833836425","https://openalex.org/W7098449782"],"abstract_inverted_index":{"Technetium-99m-galactosyl-neoglycoalbumin":[0],"(99mTc-NGA)":[1],"is":[2,186,206],"a":[3,19,85,100,104,191,198,207],"synthetic":[4],"ligand":[5,178,194],"to":[6,106,120,189],"the":[7,29,72,79,91,97,107,124,128,172,187,204],"hepatocyte":[8],"receptor,":[9],"hepatic":[10,39,181],"binding":[11],"protein":[12],"(HBP).":[13],"A":[14],"five-state":[15],"mathematical":[16],"model":[17,209],"containing":[18],"bimolecular":[20],"chemical":[21],"reaction":[22,52],"was":[23],"utilized":[24],"for":[25],"quantitative":[26],"estimation":[27],"of":[28,81,96,133,167,175,193,196,201],"following":[30],"physiologic":[31],"and":[32,43,51,55,67,76,89,93,130,158,180,203],"biochemical":[33],"parameters:":[34],"extrahepatic":[35],"plasma":[36,40,182],"volume":[37,44,53],"Ve;":[38],"flow":[41],"F":[42],"Vh;":[45],"receptor-ligand":[46],"forward-binding":[47],"rate":[48],"constant":[49],"kb":[50],"Vr;":[54],"receptor":[56,176],"concentration":[57],"[R]o.":[58],"Nine":[59],"normal":[60],"subjects":[61],"were":[62],"studied.":[63],"Given":[64],"(a)":[65],"liver":[66],"heart":[68],"time-activity":[69],"data,":[70],"(b)":[71],"patient's":[73],"weight,":[74],"height,":[75],"hematocrit,":[77],"(c)":[78],"fraction":[80,200],"injected":[82],"dose":[83],"in":[84],"3-min":[86],"blood":[87],"sample,":[88],"(d)":[90],"amount":[92],"galactose":[94],"density":[95],"NGA":[98],"dose,":[99],"computer":[101],"program":[102],"executed":[103],"curve-fit":[105],"kinetic":[108],"model.":[109],"Systematic":[110],"error,":[111],"as":[112],"measured":[113],"by":[114],"reduced":[115],"chi-square,":[116],"ranged":[117],"from":[118],"1.43":[119],"2.56.":[121],"Based":[122],"on":[123],"nine":[125],"imaging":[126],"studies,":[127],"mean":[129],"relative":[131],"error":[132],"each":[134],"parameter":[135],"were:":[136],"[R]o,":[137],"0.813":[138],"+/-":[139,144,150,155,161],"(0.11)":[140],"microM;":[141],"kb,":[142],"2.25":[143],"(0.15)":[145],"microM-1":[146],"min-1;":[147],"F,":[148],"0.896":[149],"(0.20)":[151],"liter/min;":[152],"Ve,":[153],"1.67":[154],"(0.27)":[156],"liter;":[157],"Vh,":[159],"0.228":[160],"(0.22)":[162],"liter.":[163],"Two":[164],"unique":[165],"features":[166],"99mTc-NGA":[168],"radiopharmacokinetic":[169],"systems":[170],"permit":[171],"simultaneous":[173],"estimates":[174],"quantity,":[177],"affinity,":[179],"flow.":[183],"The":[184],"first":[185],"ability":[188],"administer":[190],"quantity":[192],"capable":[195],"occupying":[197],"significant":[199],"receptor;":[202],"second":[205],"simple":[208],"structure":[210],"that":[211],"conserves":[212],"mass.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}