{"id":"https://openalex.org/W2184547360","doi":null,"title":"Lack of effect of a moderate hypocaloric diet on visfatin levels in morbid obese patients: relationship with insulin resistance.","display_name":"Lack of effect of a moderate hypocaloric diet on visfatin levels in morbid obese patients: relationship with insulin resistance.","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2184547360","mag":"2184547360","pmid":"https://pubmed.ncbi.nlm.nih.gov/21375135"},"language":"en","primary_location":{"id":"pmid:21375135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21375135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076005842","display_name":"Daniel Antonio de Luis","orcid":"https://orcid.org/0000-0002-1745-9315","observed_orcids":["https://orcid.org/0000-0002-1745-9315"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]},{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"D A De Luis","raw_affiliation_strings":["Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es","Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es","institution_ids":["https://openalex.org/I108103353","https://openalex.org/I4210158107"]},{"raw_affiliation_string":"Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid Spain","institution_ids":["https://openalex.org/I108103353","https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067155686","display_name":"Manuel Gonzalez Sagrado","orcid":"https://orcid.org/0000-0001-9878-3776","observed_orcids":["https://orcid.org/0000-0001-9878-3776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gonzalez Sagrado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037511818","display_name":"Rosa Conde","orcid":"https://orcid.org/0000-0002-6636-5729","observed_orcids":["https://orcid.org/0000-0002-6636-5729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Conde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110131905","display_name":"R. Aller","orcid":"https://orcid.org/0000-0002-6795-4541","observed_orcids":["https://orcid.org/0000-0002-6795-4541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Aller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007905745","display_name":"Olatz Izaola","orcid":"https://orcid.org/0000-0003-1201-4875","observed_orcids":["https://orcid.org/0000-0003-1201-4875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Izaola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109309598","display_name":"Castro Mj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Castro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112027978","display_name":"E. Romero","orcid":"https://orcid.org/0000-0002-0431-9591","observed_orcids":["https://orcid.org/0000-0002-0431-9591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Romero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7763,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73052061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"12","first_page":"1031","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visfatin","display_name":"visfatin","score":1.0},{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"morbid obesity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/low-calorie-diet","display_name":"hypocaloric diet","score":0.9959999918937683},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/homa","display_name":"HOMA","score":0.7400000095367432},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9430000185966492},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8614448308944702},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7936201095581055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7821910381317139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7644421458244324},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6011987328529358},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5344720482826233},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5257619023323059},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5114235281944275},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.4740859270095825},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4737815856933594},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4407200813293457},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4337582290172577},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054409","descriptor_name":"Nicotinamide Phosphoribosyltransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21375135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21375135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Clinical Trial"},{"id":"mag:2184547360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21375135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W12436271","https://openalex.org/W1822550140","https://openalex.org/W1964863934","https://openalex.org/W1966508121","https://openalex.org/W1967351112","https://openalex.org/W1985941542","https://openalex.org/W1998534694","https://openalex.org/W2009573205","https://openalex.org/W2020352897","https://openalex.org/W2022531055","https://openalex.org/W2044420976","https://openalex.org/W2066000504","https://openalex.org/W2069492997","https://openalex.org/W2116110821","https://openalex.org/W2123706364","https://openalex.org/W2135110328","https://openalex.org/W2158079900","https://openalex.org/W2160234571"],"related_works":["https://openalex.org/W1998534694","https://openalex.org/W2020352897","https://openalex.org/W2069492997","https://openalex.org/W2034058803","https://openalex.org/W4234924330","https://openalex.org/W1968744223","https://openalex.org/W2342552293","https://openalex.org/W2422538517","https://openalex.org/W2368484971","https://openalex.org/W2076712193"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,10,91],"insulin-mimetic":[2],"adipocytokine":[3],"visfatin":[4,23,95,111,143,177,206],"has":[5],"been":[6],"related":[7],"to":[8,16],"obesity.":[9],"aim":[11],"of":[12,46,94,134,148,151,168,182],"this":[13],"study":[14,42],"was":[15,39,54],"examine":[17],"whether":[18],"weight":[19,67],"loss":[20,68],"could":[21],"change":[22,203],"concentrations":[24,93,112,144,178],"in":[25,126,160,204,207],"morbidly":[26,48,208],"obese":[27,49,209],"patients":[28],"and":[29,57,88],"its":[30],"relationship":[31],"with":[32,131,145,165,179,200],"insulin":[33,87],"resistance.":[34],"MATERIAL":[35],"AND":[36],"METHODS:":[37],"This":[38],"an":[40,123,132,157,166],"interventional":[41],"analyzing":[43],"a":[44,62,114,190,194,201],"population":[45],"41":[47],"patients.":[50,210],"A":[51],"biochemical":[52],"analysis":[53,110],"realized":[55],"before":[56,129],"after":[58,163,189],"2":[59,191],"months":[60,192],"on":[61,193],"hypocaloric":[63,195],"diet.":[64],"RESULTS:":[65],"After":[66],"(average":[69],"4.41%),":[70],"BMI,":[71],"weight,":[72],"fat":[73,75],"mass,":[74,77],"free":[76],"waist":[78],"circumference,":[79],"systolic":[80],"blood":[81],"pressure,":[82],"serum":[83,92],"glucose,":[84],"total":[85],"cholesterol,":[86],"HOMA":[89,154],"decreased.":[90],"did":[96],"not":[97,198],"decrease":[98],"(43.5":[99],"+":[100,104],"30.8":[101],"vs.":[102],"47.1":[103],"38.1":[105],"ng/ml).":[106],"In":[107],"the":[108,127,161],"multivariate":[109],"as":[113,122,156],"dependent":[115],"variable,":[116],"only":[117],"C":[118],"reactive":[119],"protein":[120],"remained":[121,155],"independent":[124,158],"predictor":[125,159],"model":[128,162],"diet,":[130,164],"increase":[133,147,167,181],"1.82":[135],"ng/ml":[136,170],"(CI":[137,171],"95%:":[138,172],"0.02":[139],"-":[140,174],"3.61)":[141],"basal":[142],"each":[146,180],"1":[149,183],"mg/dl":[150],"CRP.":[152],"Only":[153],"11.4":[169],"1.76":[173],"21.11)":[175],"posttreatment":[176],"unit":[184],"HOMA.":[185],"CONCLUSION:":[186],"Weight":[187],"reduction":[188],"diet":[196],"is":[197],"associated":[199],"significant":[202],"circulating":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}