{"id":"https://openalex.org/W2184499140","doi":null,"title":"Effects of obesity and aging","display_name":"Effects of obesity and aging","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2184499140","mag":"2184499140"},"language":"en","primary_location":{"id":"mag:2184499140","doi":null,"is_oa":false,"landing_page_url":"http://care.diabetesjournals.org/content/36/1/111.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013836607","display_name":"Yoshifumi Saisho","orcid":"https://orcid.org/0000-0002-6071-4393","observed_orcids":["https://orcid.org/0000-0002-6071-4393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshifumi Saisho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6071-4393","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023255400","display_name":"Alexandra E. Butler","orcid":"https://orcid.org/0000-0002-5762-3917","observed_orcids":["https://orcid.org/0000-0002-5762-3917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra E. Butler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5762-3917","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071106967","display_name":"Erica Manesso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica Manesso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070990818","display_name":"David A. Elashoff","orcid":"https://orcid.org/0000-0002-5865-8580","observed_orcids":["https://orcid.org/0000-0002-5865-8580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Elashoff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5865-8580","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109130685","display_name":"Robert A. Rizza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Rizza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086942877","display_name":"Peter C. Butler","orcid":"https://orcid.org/0000-0002-2981-8979","observed_orcids":["https://orcid.org/0000-0002-2981-8979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C. Butler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2981-8979","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cell-mass","display_name":"beta-cell mass","score":0.8659999966621399},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9980000257492065},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/non-diabetic-individuals","display_name":"non-diabetic individuals","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.707756757736206},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5902665853500366},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.5225638747215271},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47286558151245117},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.43225693702697754},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4304657578468323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41536378860473633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39703169465065},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.38613030314445496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36713534593582153},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32848864793777466},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.2560054063796997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17027989029884338}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184499140","doi":null,"is_oa":false,"landing_page_url":"http://care.diabetesjournals.org/content/36/1/111.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1975799489","https://openalex.org/W2013389100","https://openalex.org/W2036800308","https://openalex.org/W2039486174","https://openalex.org/W2042362312","https://openalex.org/W2044949683","https://openalex.org/W2061293427","https://openalex.org/W2078849404","https://openalex.org/W2091422900","https://openalex.org/W2096773810","https://openalex.org/W2110392605","https://openalex.org/W2127825630","https://openalex.org/W2139834641","https://openalex.org/W2141202032","https://openalex.org/W2145317285","https://openalex.org/W2148147368","https://openalex.org/W2149895222"],"related_works":["https://openalex.org/W7095629522","https://openalex.org/W7074174770","https://openalex.org/W2108975920","https://openalex.org/W4242534857","https://openalex.org/W2128357880","https://openalex.org/W2154019862","https://openalex.org/W7099802280","https://openalex.org/W7098933835","https://openalex.org/W2054245920","https://openalex.org/W2995424952"],"abstract_inverted_index":{"OBJECTIVEdWe":[0],"sought":[1],"to":[2,14],"establish":[3],"b-cell":[4,6,9,57],"mass,":[5],"apoptosis,":[7],"and":[8,16,43,47],"replication":[10,58],"inhumans":[11],"in":[12,40,54,61,85],"response":[13],"obesity":[15,36,70],"advanced":[17,72],"age.RESEARCH":[18],"DESIGN":[19],"AND":[20],"METHODSdWe":[21],"examined":[22,53],"human":[23],"autopsy":[24],"pancreas":[25],"from167":[26],"nondiabetic":[27],"individuals":[28],"20\u2013102":[29],"years":[30],"of":[31,35,50,76],"age.":[32],"The":[33],"effect":[34,49],"onb-cell":[37],"mass":[38,81],"wasexamined":[39],"53":[41],"lean":[42,62],"61":[44],"obese":[45],"subjects,":[46],"the":[48,74],"aging":[51],"was":[52],"106":[55],"leansubjects.RESULTSdb-Cellmassisincreasedby;50%withobesity(from0.8to1.2g).Withadvancedaging,theexocrinepancreasundergoesatrophybutb-cellmassisremarkablypreserved.Thereisminimal":[56],"or":[59,71],"apoptosis":[60],"humans":[63,86],"throughout":[64],"life":[65],"with":[66,69,87],"no":[67],"detectablechanges":[68],"age.CONCLUSIONSdb-Cellmassinhumanobesityincreasesby;50%byanincreaseinb-cellnumber,":[73],"source":[75],"which":[77],"is":[78,82],"unknown.":[79],"b-Cell":[80],"well":[83],"preserved":[84],"ad-vanced":[88],"aging.":[89]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
