{"id":"https://openalex.org/W2184489869","doi":"https://doi.org/10.1098/rsob.150042","title":"Defining the robust behaviour of the plant clock gene circuit with absolute RNA timeseries and open infrastructure","display_name":"Defining the robust behaviour of the plant clock gene circuit with absolute RNA timeseries and open infrastructure","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2184489869","doi":"https://doi.org/10.1098/rsob.150042","mag":"2184489869","pmid":"https://pubmed.ncbi.nlm.nih.gov/26468131","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4632509"},"language":"en","primary_location":{"id":"doi:10.1098/rsob.150042","doi":"https://doi.org/10.1098/rsob.150042","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.150042","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1098/rsob.150042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067679478","display_name":"Anna Flis","orcid":"https://orcid.org/0000-0002-9142-1606","observed_orcids":["https://orcid.org/0000-0002-9142-1606"]},"institutions":[{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Flis","raw_affiliation_strings":["Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079227452","display_name":"Aurora Pi\u00f1as Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aurora Pi\u00f1as Fern\u00e1ndez","raw_affiliation_strings":["SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038044244","display_name":"T. Zieli\u0144ski","orcid":"https://orcid.org/0000-0002-0194-5706","observed_orcids":["https://orcid.org/0000-0002-0194-5706"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tomasz Zielinski","raw_affiliation_strings":["SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063047492","display_name":"Virginie Mengin","orcid":"https://orcid.org/0000-0002-4958-4209","observed_orcids":["https://orcid.org/0000-0002-4958-4209"]},"institutions":[{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Virginie Mengin","raw_affiliation_strings":["Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021262425","display_name":"Ronan Sulpice","orcid":"https://orcid.org/0000-0002-6113-9570","observed_orcids":["https://orcid.org/0000-0002-6113-9570"]},"institutions":[{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronan Sulpice","raw_affiliation_strings":["Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025579578","display_name":"Kevin Stratford","orcid":"https://orcid.org/0000-0003-3491-2190","observed_orcids":["https://orcid.org/0000-0003-3491-2190"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Stratford","raw_affiliation_strings":["EPCC, University of Edinburgh, James Clerk Maxwell Building, Edinburgh EH9 3JZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPCC, University of Edinburgh, James Clerk Maxwell Building, Edinburgh EH9 3JZ, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058031728","display_name":"Alastair C. Hume","orcid":"https://orcid.org/0000-0001-8322-9182","observed_orcids":["https://orcid.org/0000-0001-8322-9182"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alastair Hume","raw_affiliation_strings":["EPCC, University of Edinburgh, James Clerk Maxwell Building, Edinburgh EH9 3JZ, UK","SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPCC, University of Edinburgh, James Clerk Maxwell Building, Edinburgh EH9 3JZ, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052905184","display_name":"Alexandra V. Pokhilko","orcid":"https://orcid.org/0000-0001-6565-6551","observed_orcids":["https://orcid.org/0000-0001-6565-6551"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexandra Pokhilko","raw_affiliation_strings":["Institute of Molecular Cell and Systems Biology, University of Glasgow, Bower Building, Glasgow G12 8QQ, UK","SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Cell and Systems Biology, University of Glasgow, Bower Building, Glasgow G12 8QQ, UK","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078403227","display_name":"Megan M. Southern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Megan M. Southern","raw_affiliation_strings":["Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050394882","display_name":"Daniel D. Seaton","orcid":"https://orcid.org/0000-0002-5222-3893","observed_orcids":["https://orcid.org/0000-0002-5222-3893"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel D. Seaton","raw_affiliation_strings":["SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033937652","display_name":"Harriet G. McWatters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harriet G. McWatters","raw_affiliation_strings":["SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066445561","display_name":"Mark Stitt","orcid":"https://orcid.org/0000-0002-4900-1763","observed_orcids":["https://orcid.org/0000-0002-4900-1763","https://orcid.org/0000-0002-8501-7164"]},"institutions":[{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mark Stitt","raw_affiliation_strings":["Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025865254","display_name":"Karen Halliday","orcid":"https://orcid.org/0000-0003-0467-104X","observed_orcids":["https://orcid.org/0000-0003-0467-104X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Karen J. Halliday","raw_affiliation_strings":["SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079005978","display_name":"Andrew John Millar","orcid":"https://orcid.org/0000-0003-1756-3654","observed_orcids":["https://orcid.org/0000-0003-1756-3654"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew J. Millar","raw_affiliation_strings":["SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK"],"raw_orcid":"https://orcid.org/0000-0003-1756-3654","affiliations":[{"raw_affiliation_string":"SynthSys and School of Biological Sciences, University of Edinburgh, C.H. Waddington Building, Edinburgh EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025865254","https://openalex.org/A5066445561","https://openalex.org/A5079005978"],"corresponding_institution_ids":["https://openalex.org/I4210105972","https://openalex.org/I98677209"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1680,"currency":"EUR","value_usd":1811},"fwci":2.55,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.8861267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"5","issue":"10","first_page":"150042","last_page":"150042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.1891999989748001,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.8859999775886536},{"id":"https://openalex.org/keywords/clock-gene-expression","display_name":"clock gene expression","score":0.7409999966621399},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9440000057220459},{"id":"https://openalex.org/keywords/transcriptional-feedback-loop","display_name":"transcriptional feedback loop","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prr9","display_name":"PRR9","score":0.9020000100135803},{"id":"https://openalex.org/keywords/elf4","display_name":"ELF4","score":0.9399999976158142},{"id":"https://openalex.org/keywords/prr5","display_name":"PRR5","score":0.9580000042915344},{"id":"https://openalex.org/keywords/late-elongated-hypocotyl","display_name":"LHY","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cca1","display_name":"CCA1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.6019999980926514},{"id":"https://openalex.org/keywords/open-data-infrastructure","display_name":"open data infrastructure","score":0.5419999957084656},{"id":"https://openalex.org/keywords/data-aggregation","display_name":"data aggregation","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7927255630493164},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6951115131378174},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.5916448831558228},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.561850905418396},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4682914614677429},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4652382433414459},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.4552459120750427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4536657929420471},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.336133748292923},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3190252482891083}],"mesh":[{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056926","descriptor_name":"CLOCK Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1098/rsob.150042","doi":"https://doi.org/10.1098/rsob.150042","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.150042","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3625797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4632509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26468131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26468131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4632509","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4632509/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biol","raw_type":"Text"},{"id":"pmh:oai:eprints.gla.ac.uk:113274","doi":null,"is_oa":false,"landing_page_url":"https://eprints.gla.ac.uk/view/journal_volume/Open_Biology.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/b04f905c-911b-41eb-a7e9-88e74ecc6439","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/b04f905c-911b-41eb-a7e9-88e74ecc6439","pdf_url":"https://www.research.ed.ac.uk/files/24976681/rsob_150042_all.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Flis, A, Fern\u00e1ndez, A P, Zielinski, T, Mengin, V, Sulpice, R, Stratford, K, Hume, A, Pokhilko, A, Southern, M M, Seaton, D D, McWatters, H G, Stitt, M, Halliday, K J & Millar, A J 2015, 'Defining the robust behaviour of the plant clock gene circuit with absolute RNA timeseries and open infrastructure', Open Biology, vol. 5, no. 10, 150042. https://doi.org/10.1098/rsob.150042","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:4ee84592a7124c0c979fa3f37779edac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4ee84592a7124c0c979fa3f37779edac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Biology, Vol 5, Iss 10 (2015)","raw_type":"article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/153704","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/153704","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Biology","raw_type":"Journal article"},{"id":"pmh:oai:pure.mpg.de:item_2224210","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0028-E3BA-E","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:zenodo.org:32415","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/32415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Royal Society Open Biology, (2015-09-24)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1098/rsob.150042","doi":"https://doi.org/10.1098/rsob.150042","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.150042","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2128708434","display_name":"Regulation of biological signalling by temperature (ROBUST)","funder_award_id":"BB/F005237/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2160003213","display_name":null,"funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4057390412","display_name":null,"funder_award_id":"BB/N012348/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5187560155","display_name":"Regulation of biological signalling by temperature (ROBUST)","funder_award_id":"BB/F005296/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5281516419","display_name":"Experimental methods and modelling for multiscale biology","funder_award_id":"BB/N012348/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7808425888","display_name":null,"funder_award_id":"BB/F005296/2","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8204230365","display_name":null,"funder_award_id":"BB/F005296/2","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G922893353","display_name":"Centre for Systems Biology at Edinburgh","funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2184489869.pdf","grobid_xml":"https://content.openalex.org/works/W2184489869.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1484075860","https://openalex.org/W1526071261","https://openalex.org/W1530371171","https://openalex.org/W1548849615","https://openalex.org/W1558471429","https://openalex.org/W1638486002","https://openalex.org/W1699155395","https://openalex.org/W1757084193","https://openalex.org/W1966076168","https://openalex.org/W1969042907","https://openalex.org/W1972113569","https://openalex.org/W1976329436","https://openalex.org/W1980205405","https://openalex.org/W1983289412","https://openalex.org/W1988756474","https://openalex.org/W1991363773","https://openalex.org/W1995514362","https://openalex.org/W2003846898","https://openalex.org/W2005161380","https://openalex.org/W2006324678","https://openalex.org/W2007091097","https://openalex.org/W2007343477","https://openalex.org/W2007897769","https://openalex.org/W2011265440","https://openalex.org/W2014034577","https://openalex.org/W2015950073","https://openalex.org/W2017203435","https://openalex.org/W2017470450","https://openalex.org/W2020509277","https://openalex.org/W2022442940","https://openalex.org/W2028404018","https://openalex.org/W2029617077","https://openalex.org/W2034412540","https://openalex.org/W2042167665","https://openalex.org/W2046431625","https://openalex.org/W2046879305","https://openalex.org/W2048792111","https://openalex.org/W2055531437","https://openalex.org/W2056657640","https://openalex.org/W2057294415","https://openalex.org/W2058651702","https://openalex.org/W2059746610","https://openalex.org/W2059761249","https://openalex.org/W2060903072","https://openalex.org/W2063385984","https://openalex.org/W2069157810","https://openalex.org/W2081409037","https://openalex.org/W2086068316","https://openalex.org/W2089068724","https://openalex.org/W2090950329","https://openalex.org/W2093122082","https://openalex.org/W2095754390","https://openalex.org/W2098130298","https://openalex.org/W2101122984","https://openalex.org/W2104266531","https://openalex.org/W2105802340","https://openalex.org/W2107062718","https://openalex.org/W2109219892","https://openalex.org/W2112210924","https://openalex.org/W2112542744","https://openalex.org/W2113175276","https://openalex.org/W2116300687","https://openalex.org/W2118348421","https://openalex.org/W2118874817","https://openalex.org/W2119683067","https://openalex.org/W2120260648","https://openalex.org/W2120988531","https://openalex.org/W2123928201","https://openalex.org/W2126676706","https://openalex.org/W2128362727","https://openalex.org/W2128657634","https://openalex.org/W2135007181","https://openalex.org/W2136081741","https://openalex.org/W2136120517","https://openalex.org/W2137318779","https://openalex.org/W2137492151","https://openalex.org/W2137907499","https://openalex.org/W2138205632","https://openalex.org/W2139837544","https://openalex.org/W2140688829","https://openalex.org/W2143934568","https://openalex.org/W2149168415","https://openalex.org/W2149656802","https://openalex.org/W2150908245","https://openalex.org/W2150998297","https://openalex.org/W2151656896","https://openalex.org/W2152588225","https://openalex.org/W2154333461","https://openalex.org/W2156444576","https://openalex.org/W2157647092","https://openalex.org/W2159130719","https://openalex.org/W2161304688","https://openalex.org/W2163993275","https://openalex.org/W2164166968","https://openalex.org/W2164965140","https://openalex.org/W2166639411","https://openalex.org/W2168097370","https://openalex.org/W2177802280","https://openalex.org/W2486011972"],"related_works":["https://openalex.org/W7098903810","https://openalex.org/W3188339268","https://openalex.org/W4407761883","https://openalex.org/W1500740016","https://openalex.org/W2164600365","https://openalex.org/W2274818760","https://openalex.org/W2048792111","https://openalex.org/W4412985364","https://openalex.org/W2149656802","https://openalex.org/W2135007181"],"abstract_inverted_index":{"Our":[0],"understanding":[1,183],"of":[2,81,87,97,114,123],"the":[3,9,55,174,190,193,198],"complex,":[4],"transcriptional":[5],"feedback":[6],"loops":[7],"in":[8,28,39,43,68,156,182],"circadian":[10],"clock":[11,24,108,153],"mechanism":[12],"has":[13],"depended":[14],"upon":[15],"quantitative,":[16],"timeseries":[17,139],"data":[18,129,149,180],"from":[19,132],"disparate":[20],"sources.":[21],"We":[22,172],"measure":[23],"gene":[25,154],"RNA":[26,49,92,116],"profiles":[27,50],"Arabidopsis":[29],"thaliana":[30],"seedlings,":[31],"grown":[32],"with":[33,106],"or":[34,38,170],"without":[35,167],"exogenous":[36],"sucrose,":[37],"soil-grown":[40],"plants":[41],"and":[42,45,83,85,110,176,192],"wild-type":[44],"mutant":[46],"backgrounds.":[47],"The":[48,128],"were":[51],"strikingly":[52],"robust":[53],"across":[54],"experimental":[56],"conditions,":[57],"so":[58],"current":[59],"mathematical":[60,177],"models":[61],"are":[62,130],"likely":[63],"to":[64,73,144,201],"be":[65],"broadly":[66],"applicable":[67],"leaf":[69],"tissue.":[70],"In":[71],"addition":[72],"providing":[74],"reference":[75],"data,":[76,140],"unexpected":[77],"behaviours":[78],"included":[79],"co-expression":[80],"PRR9":[82,98],"ELF4,":[84],"regulation":[86],"PRR5":[88],"by":[89],"GI.":[90],"Absolute":[91],"quantification":[93],"revealed":[94],"low":[95],"levels":[96,113],"transcripts":[99],"(peak":[100],"approx.":[101],"50":[102],"copies":[103,120],"cell(-1))":[104,121],"compared":[105],"other":[107],"genes,":[109],"threefold":[111],"higher":[112],"LHY":[115],"(more":[117],"than":[118,122],"1500":[119],"its":[124],"close":[125],"relative":[126],"CCA1.":[127],"disseminated":[131],"BioDare,":[133],"an":[134],"online":[135],"repository":[136],"for":[137,179],"focused":[138],"which":[141],"is":[142],"expected":[143],"benefit":[145],"mechanistic":[146],"modelling.":[147],"One":[148],"subset":[150],"successfully":[151],"constrained":[152],"expression":[155],"a":[157],"complex":[158],"model,":[159],"using":[160],"publicly":[161],"available":[162],"software":[163],"on":[164,197],"parallel":[165],"computers,":[166],"expert":[168],"tuning":[169],"programming.":[171],"outline":[173],"empirical":[175],"justification":[178],"aggregation":[181],"highly":[184],"interconnected,":[185],"dynamic":[186],"networks":[187],"such":[188],"as":[189],"clock,":[191],"observed":[194],"design":[195],"constraints":[196],"resources":[199],"required":[200],"make":[202],"this":[203],"approach":[204],"widely":[205],"accessible.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}