{"id":"https://openalex.org/W2184477860","doi":null,"title":"DEVELOPMENT OF PROPRANOLOL HYDROCHLORIDE MATRIX TABLETS: AN INVESTIGATION ON EFFECTS OF COMBINATION OF HYDROPHILIC AND HYDROPHOBIC MATRIX FORMERS USING MULTIPLE COMPARISON ANALYSIS","display_name":"DEVELOPMENT OF PROPRANOLOL HYDROCHLORIDE MATRIX TABLETS: AN INVESTIGATION ON EFFECTS OF COMBINATION OF HYDROPHILIC AND HYDROPHOBIC MATRIX FORMERS USING MULTIPLE COMPARISON ANALYSIS","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2184477860","mag":"2184477860"},"language":"en","primary_location":{"id":"mag:2184477860","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/volume1issue2/article 001.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048383008","display_name":"Madhusmruti Khandai","orcid":"https://orcid.org/0000-0003-4024-9735","observed_orcids":["https://orcid.org/0000-0003-4024-9735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhusmruti Khandai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4024-9735","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013895971","display_name":"Santanu Chakraborty","orcid":"https://orcid.org/0000-0003-4358-2031","observed_orcids":["https://orcid.org/0000-0003-4358-2031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santanu Chakraborty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4358-2031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031280653","display_name":"Anuradha Sharma","orcid":"https://orcid.org/0000-0003-2693-4760","observed_orcids":["https://orcid.org/0000-0003-2693-4760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anuradha Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2693-4760","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037089307","display_name":"Dibya Sundar Panda","orcid":"https://orcid.org/0000-0002-8986-1100","observed_orcids":["https://orcid.org/0000-0002-8986-1100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dibya Sundar Panda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8986-1100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029027068","display_name":"Nazia Khanam","orcid":"https://orcid.org/0000-0001-6399-6296","observed_orcids":["https://orcid.org/0000-0001-6399-6296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nazia Khanam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Santosh Kumar Panda","orcid":"https://orcid.org/0000-0003-0606-6548","observed_orcids":["https://orcid.org/0000-0003-0606-6548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santosh Kumar Panda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0606-6548","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2213,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.46633103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propranolol-hydrochloride","display_name":"propranolol hydrochloride","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7170000076293945},{"id":"https://openalex.org/keywords/matrix-tablets","display_name":"matrix tablets","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ethylcellulose","display_name":"ethyl cellulose","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hydrophilic-and-hydrophobic-polymers","display_name":"hydrophilic and hydrophobic polymers","score":0.8889999985694885},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.9309999942779541},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tablet-swelling","display_name":"tablet swelling","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tablet-erosion","display_name":"tablet erosion","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-polymer-compatibility","display_name":"drug-polymer compatibility","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2909915070","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol Hydrochloride","level":3,"score":0.7747939825057983},{"id":"https://openalex.org/C191168616","wikidata":"https://www.wikidata.org/wiki/Q5503337","display_name":"Friability","level":4,"score":0.7682146430015564},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.6716390252113342},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.6176639795303345},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.6153892278671265},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.5599305033683777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5155196189880371},{"id":"https://openalex.org/C2776035855","wikidata":"https://www.wikidata.org/wiki/Q420113","display_name":"Ethyl cellulose","level":3,"score":0.4509172737598419},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.43497171998023987},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4331973195075989},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.42376238107681274},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3375672698020935},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.21015334129333496},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1999935805797577},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.19922322034835815},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184477860","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/volume1issue2/article 001.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W176397689","https://openalex.org/W289778840","https://openalex.org/W1534365114","https://openalex.org/W1543693818","https://openalex.org/W1977072597","https://openalex.org/W1991274230","https://openalex.org/W1997771296","https://openalex.org/W2023571229","https://openalex.org/W2039699933","https://openalex.org/W2078321779","https://openalex.org/W2079407952","https://openalex.org/W2083385689","https://openalex.org/W2087969058","https://openalex.org/W2094318176","https://openalex.org/W2108042514","https://openalex.org/W2115770965","https://openalex.org/W2133433956","https://openalex.org/W2426535055"],"related_works":["https://openalex.org/W2927130740","https://openalex.org/W3170967570","https://openalex.org/W2604707620","https://openalex.org/W2184083340","https://openalex.org/W4381429569","https://openalex.org/W2071140740","https://openalex.org/W2360023969","https://openalex.org/W2942991461","https://openalex.org/W2276070292","https://openalex.org/W2287192731"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,13,20,41,65,118,126,145,217,232],"the":[3,18,116,128,131,139,152,159,173,204,212,215,227],"present":[4],"work":[5],"was":[6,122,195],"to":[7,52,74,103,137],"develop":[8],"sustain":[9,138],"release":[10,77,99,133,141,229],"matrix":[11,153,174,230],"formulation":[12],"Propranolol":[14],"hydrochloride":[15],"and":[16,23,44,68,105,135,166,175,190,209,220],"investigate":[17],"effects":[19],"both":[21,127,218],"hydrophilic":[22,219],"hydrophobic":[24,221],"polymers":[25,129,222],"on":[26],"in-vitro":[27],"drug":[28,60,76,98,119,140,189],"release.":[29,120],"Matrix":[30],"tablets":[31,154,231],"were":[32,50,72,101],"prepared":[33],"by":[34,89],"direct":[35],"compression":[36],"method":[37],"using":[38],"different":[39],"concentration":[40],"Hydroxypropylmethylcellulose":[42],"(HPMC)":[43],"Ethyl":[45],"Cellulose":[46],"(EC).":[47],"Prepared":[48],"formulations":[49],"subjected":[51,73],"various":[53],"studies":[54],"like":[55],"hardness,":[56],"friability,":[57],"thickness,":[58],"%":[59],"content,":[61],"weight":[62],"variation,":[63],"dynamics":[64],"water":[66,165],"uptake":[67],"erosion":[69,113,177],"etc.":[70],"Tablets":[71],"In-Vitro":[75],"in":[78,156,203],"0.1":[79],"N":[80],"HCl":[81],"(pH":[82,92],"1.2)":[83],"for":[84,94,142,225],"first":[85],"2":[86],"hours":[87],"followed":[88],"phosphate":[90],"buffer":[91],"6.8)":[93],"remaining":[95],"hours.":[96],"In-vitro":[97],"data":[100],"fitting":[102],"Higuchi":[104,206],"Korsmeyer":[106],"equation":[107],"indicated":[108],"that":[109,124,150,184,197],"diffusion":[110],"along":[111],"with":[112,158],"could":[114],"be":[115],"mechanism":[117],"It":[121],"observed":[123],"combination":[125,216],"exhibited":[130],"best":[132],"profile":[134],"able":[136],"prolong":[143],"period":[144],"time.":[146],"Swelling":[147],"study":[148],"suggested":[149],"when":[151],"come":[155],"contact":[157],"dissolution":[160],"medium,":[161],"they":[162],"take":[163],"up":[164],"swells,":[167],"forming":[168],"a":[169,200],"gel":[170],"layer":[171],"around":[172],"simultaneously":[176],"also":[178],"takes":[179],"place.":[180],"FT-IR":[181],"spectra":[182],"revealed":[183],"there":[185,198],"no":[186],"interaction":[187],"between":[188],"polymers.":[191],"Multiple":[192],"comparison":[193],"analysis":[194],"confirmed":[196],"exists":[199],"significant":[201],"difference":[202],"measured":[205],"rate":[207],"constant":[208],"t50%":[210],"among":[211],"matrices.":[213],"So":[214],"successfully":[223],"employed":[224],"formulating":[226],"sustained":[228],"propranolol":[233],"hydrochloride.":[234]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}