{"id":"https://openalex.org/W2184476053","doi":null,"title":"How to Identify Systemic Sepsis-Induced Immunoparalysis","display_name":"How to Identify Systemic Sepsis-Induced Immunoparalysis","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2184476053","mag":"2184476053"},"language":"en","primary_location":{"id":"mag:2184476053","doi":null,"is_oa":false,"landing_page_url":"https://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/intmed/imrp/CURRICULUM/Documents/AB1.Sepsis_Pathophysiology%2814%29.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004262919","display_name":"Guillaume Monneret","orcid":"https://orcid.org/0000-0002-9961-5739","observed_orcids":["https://orcid.org/0000-0002-9961-5739"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guillaume Monneret","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9961-5739","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004262919"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.282,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.80320513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immunoparalysis","display_name":"immunoparalysis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/immunodepression","display_name":"immunodepression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hla-dr-expression","display_name":"HLA-DR expression","score":0.7789999842643738},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6060000061988831},{"id":"https://openalex.org/keywords/secondary-infection","display_name":"secondary infection","score":0.6790000200271606},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7126272320747375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.66142737865448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6496161222457886},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6475977897644043},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6280679702758789},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.6129876971244812},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5977628827095032}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184476053","doi":null,"is_oa":false,"landing_page_url":"https://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/intmed/imrp/CURRICULUM/Documents/AB1.Sepsis_Pathophysiology%2814%29.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W9981564","https://openalex.org/W70891143","https://openalex.org/W1499659307","https://openalex.org/W1505290244","https://openalex.org/W1569758706","https://openalex.org/W1570331116","https://openalex.org/W1599263328","https://openalex.org/W1786413083","https://openalex.org/W1917557897","https://openalex.org/W1926790978","https://openalex.org/W1937605809","https://openalex.org/W1968434197","https://openalex.org/W1972757665","https://openalex.org/W1976467135","https://openalex.org/W1976554265","https://openalex.org/W1977905350","https://openalex.org/W1980123081","https://openalex.org/W1986014873","https://openalex.org/W1992893247","https://openalex.org/W1993065921","https://openalex.org/W2004072697","https://openalex.org/W2005435076","https://openalex.org/W2006076737","https://openalex.org/W2007531589","https://openalex.org/W2009276059","https://openalex.org/W2009286881","https://openalex.org/W2013860796","https://openalex.org/W2015339876","https://openalex.org/W2016541749","https://openalex.org/W2016927297","https://openalex.org/W2019043807","https://openalex.org/W2021977392","https://openalex.org/W2041084237","https://openalex.org/W2041279219","https://openalex.org/W2044904185","https://openalex.org/W2049366031","https://openalex.org/W2049927822","https://openalex.org/W2053721185","https://openalex.org/W2056562851","https://openalex.org/W2061402985","https://openalex.org/W2062308880","https://openalex.org/W2062328478","https://openalex.org/W2070335635","https://openalex.org/W2070476093","https://openalex.org/W2070743921","https://openalex.org/W2078781072","https://openalex.org/W2080442596","https://openalex.org/W2081066275","https://openalex.org/W2086083704","https://openalex.org/W2087203965","https://openalex.org/W2088220499","https://openalex.org/W2089557438","https://openalex.org/W2092449249","https://openalex.org/W2093287784","https://openalex.org/W2093892740","https://openalex.org/W2101895495","https://openalex.org/W2106530602","https://openalex.org/W2130610340","https://openalex.org/W2131630407","https://openalex.org/W2141778986","https://openalex.org/W2143682143","https://openalex.org/W2160691650","https://openalex.org/W2163814324","https://openalex.org/W2550507245"],"related_works":["https://openalex.org/W7222717979","https://openalex.org/W112474814","https://openalex.org/W4319346776","https://openalex.org/W2465883395","https://openalex.org/W4367606872","https://openalex.org/W4406296736","https://openalex.org/W2972622012","https://openalex.org/W2058200727","https://openalex.org/W2062216586","https://openalex.org/W1984666117"],"abstract_inverted_index":{"The":[0,45,76],"body":[1,54],"develops":[2],"compensatory":[3],"mechanisms":[4,22],"to":[5,11,55,68,83],"prevent":[6],"systemic":[7],"inflammation":[8,17],"in":[9,107],"response":[10],"stress":[12],"and":[13,74,119],"injury.":[14,33],"As":[15],"overwhelming":[16],"is":[18,66,93],"rapidly":[19],"lethal,":[20],"these":[21],"have":[23],"a":[24],"protective":[25],"effect":[26],"during":[27],"the":[28,49,53,62,89],"first":[29],"few":[30],"hours":[31],"after":[32],"However,":[34],"they":[35],"become":[36],"deleterious":[37],"as":[38],"nearly":[39],"all":[40],"immune":[41,60,85],"functions":[42],"are":[43],"compromised.":[44],"term":[46],"\u201cimmunoparalysis\u201d":[47],"describes":[48],"global":[50],"incapacity":[51],"of":[52,59,64,91,110],"mount":[56],"any":[57],"kind":[58],"response;":[61],"extent":[63],"immunoparalysis":[65],"thought":[67],"correlate":[69],"with":[70],"life-threatening":[71],"secondary":[72],"infections":[73],"mortality.":[75],"hypoimmune":[77],"state":[78],"might":[79],"require":[80],"proinflammatory":[81],"therapies":[82],"enhance":[84],"function,":[86],"but":[87],"establishing":[88],"presence":[90],"immunodepression":[92],"crucial":[94],"when":[95],"considering":[96],"such":[97],"an":[98],"approach.":[99],"This":[100],"article":[101],"discusses":[102],"methods":[103],"for":[104],"diagnosing":[105],"immunoparalysis,":[106],"particular":[108],"measurements":[109],"circulating":[111],"monocyte":[112],"human":[113],"leukocyte":[114],"antigen":[115],"type":[116],"DR":[117],"expression":[118]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":63}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}