{"id":"https://openalex.org/W2184450187","doi":null,"title":"Daily 500 mg valacyclovir is effective for prevention of Varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib.","display_name":"Daily 500 mg valacyclovir is effective for prevention of Varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib.","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2184450187","mag":"2184450187","pmid":"https://pubmed.ncbi.nlm.nih.gov/23225448"},"language":"en","primary_location":{"id":"pmid:23225448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23225448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110198096","display_name":"Toshihiro Fukushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Fukushima","raw_affiliation_strings":["Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. tfukus@kanazawa-med.ac.jp","Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293 (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. tfukus@kanazawa-med.ac.jp","institution_ids":["https://openalex.org/I16568816"]},{"raw_affiliation_string":"Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293 (Japan)","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101551288","display_name":"Tomomi Sato","orcid":"https://orcid.org/0000-0003-2884-1488","observed_orcids":["https://orcid.org/0000-0003-2884-1488"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Sato","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717573","display_name":"Takuji Nakamura","orcid":"https://orcid.org/0000-0001-9921-6327","observed_orcids":["https://orcid.org/0000-0001-9921-6327"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuji Nakamura","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090521080","display_name":"Haruka Kawanami Iwao","orcid":"https://orcid.org/0000-0002-4986-5473","observed_orcids":["https://orcid.org/0000-0002-4986-5473"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Iwao","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003204127","display_name":"Akio Nakajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Nakajima","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019926116","display_name":"Miyuki Miki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyuki Miki","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069916638","display_name":"Tomoyuki Sakai","orcid":"https://orcid.org/0000-0002-5533-3465","observed_orcids":["https://orcid.org/0000-0002-5533-3465"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Sakai","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111992506","display_name":"Takafumi Kawanami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Kawanami","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073388784","display_name":"Toshioki Sawaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshioki Sawaki","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109831763","display_name":"Yoshimasa Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Fujita","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078409741","display_name":"Masao Tanaka","orcid":"https://orcid.org/0000-0002-8942-2933","observed_orcids":["https://orcid.org/0000-0002-8942-2933"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Tanaka","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061841627","display_name":"Yasufumi Masaki","orcid":"https://orcid.org/0000-0002-5658-3765","observed_orcids":["https://orcid.org/0000-0002-5658-3765"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasufumi Masaki","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091657418","display_name":"Toshiro Okazaki","orcid":"https://orcid.org/0000-0002-1667-841X","observed_orcids":["https://orcid.org/0000-0002-1667-841X"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiro Okazaki","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105655548","display_name":"Hideo Nakajima","orcid":"https://orcid.org/0000-0003-4314-8139","observed_orcids":["https://orcid.org/0000-0003-4314-8139"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Nakajima","raw_affiliation_strings":["2Department of Medical Oncology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medical Oncology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008116561","display_name":"Yoshiharu Motoo","orcid":"https://orcid.org/0000-0002-0776-6434","observed_orcids":["https://orcid.org/0000-0002-0776-6434"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiharu Motoo","raw_affiliation_strings":["2Department of Medical Oncology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medical Oncology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014411218","display_name":"Hisanori Umehara","orcid":"https://orcid.org/0000-0001-9833-4647","observed_orcids":["https://orcid.org/0000-0001-9833-4647"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisanori Umehara","raw_affiliation_strings":["1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16568816"],"apc_list":null,"apc_paid":null,"fwci":1.1935,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.8003875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"32","issue":"12","first_page":"5437","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valacyclovir","display_name":"valacyclovir","score":0.9729999899864197},{"id":"https://openalex.org/keywords/varicella-zoster-virus-reactivation","display_name":"varicella-zoster virus reactivation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":1.0},{"id":"https://openalex.org/keywords/antiviral-prophylaxis","display_name":"antiviral prophylaxis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/herpes-zoster-prevention","display_name":"herpes zoster prevention","score":0.9179999828338623},{"id":"https://openalex.org/keywords/drug-induced-immunosuppression","display_name":"drug-induced immunosuppression","score":0.6000000238418579},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.6389999985694885},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8829753994941711},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.7493369579315186},{"id":"https://openalex.org/C2780452071","wikidata":"https://www.wikidata.org/wiki/Q418594","display_name":"Valaciclovir","level":5,"score":0.6862053871154785},{"id":"https://openalex.org/C2776159415","wikidata":"https://www.wikidata.org/wiki/Q6868","display_name":"Varicella zoster virus","level":3,"score":0.5847218632698059},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5566730499267578},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.556473970413208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47347772121429443},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39940208196640015},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37508460879325867},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2530830502510071},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23622703552246094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21690163016319275},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.14676639437675476}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077483","descriptor_name":"Valacyclovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006562","descriptor_name":"Herpes Zoster","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006562","descriptor_name":"Herpes Zoster","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014645","descriptor_name":"Herpesvirus 3, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23225448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23225448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2184450187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23225448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1516702206","https://openalex.org/W1764666559","https://openalex.org/W1946382681","https://openalex.org/W1978643311","https://openalex.org/W2007730238","https://openalex.org/W2010552629","https://openalex.org/W2019827424","https://openalex.org/W2025975417","https://openalex.org/W2085861918","https://openalex.org/W2096207943","https://openalex.org/W2108235071","https://openalex.org/W2110466835","https://openalex.org/W2114832110","https://openalex.org/W2117172636","https://openalex.org/W2117543423","https://openalex.org/W2120474651","https://openalex.org/W2124560610","https://openalex.org/W2126077674","https://openalex.org/W2133590829","https://openalex.org/W2141169323","https://openalex.org/W2146502962","https://openalex.org/W2151595053","https://openalex.org/W2159195400","https://openalex.org/W2164807675"],"related_works":["https://openalex.org/W2980997149","https://openalex.org/W2007730238","https://openalex.org/W2117543423","https://openalex.org/W1516702206","https://openalex.org/W2114832110","https://openalex.org/W2595700630","https://openalex.org/W2412230240","https://openalex.org/W2523981896","https://openalex.org/W4220807150","https://openalex.org/W2561342313"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"patients":[2,58,100,117,159,203],"with":[3,10,59,177,204],"multiple":[4],"myeloma":[5],"(MM),":[6],"bortezomib":[7,63,88,109],"is":[8],"associated":[9,176],"a":[11,45,79,162,185],"significant":[12],"risk":[13,28],"of":[14,29,47,81,124,165,187],"Varicella":[15],"zoster":[16],"virus":[17],"(VZV)":[18],"reactivation.":[19,31],"There":[20],"are":[21],"some":[22],"reports":[23],"that":[24],"acyclovir":[25],"reduces":[26],"the":[27,68,133],"VZV":[30,35,142,152,166,197],"We":[32,54],"assessed":[33],"whether":[34],"reactivation":[36,143,153,167,198],"could":[37],"be":[38,193],"reduced":[39],"by":[40,202],"using":[41],"prophylactic":[42],"valacyclovir":[43,65,75,125,135,150,169,178],"at":[44,67,78,184,195],"dose":[46,80,110,136,186],"500":[48,82,188],"mg":[49,83,189],"daily.":[50],"PATIENTS":[51],"AND":[52],"METHODS:":[53],"retrospectively":[55],"evaluated":[56],"32":[57],"MM":[60,205],"who":[61,160,206],"received":[62,74,119,207],"and":[64,103,132,199],"prophylaxis":[66,76,126],"Kanazawa":[69],"Medical":[70],"University":[71],"Hospital.":[72],"Patients":[73],"orally":[77],"daily,":[84],"without":[85,168],"cessation":[86],"during":[87,149],"treatment.":[89],"RESULTS:":[90],"The":[91,107,121],"median":[92,108,122,134],"age":[93],"was":[94,111,127,137,200],"69":[95],"years":[96],"(range=45-90":[97],"years).":[98],"Fifteen":[99],"were":[101,105,179],"male":[102],"seventeen":[104],"female.":[106],"37.0":[112],"mg/m(2)":[113],"(range=5.2-167.6":[114],"mg/m(2)).":[115],"All":[116],"also":[118],"corticosteroids.":[120],"duration":[123],"301":[128],"days":[129],"(range=24-1206":[130],"days)":[131],"150.5":[138],"g":[139],"(range=12-603":[140],"g).":[141],"developed":[144],"in":[145,157],"only":[146],"one":[147],"patient":[148],"prophylaxis.":[151,170],"did":[154],"not":[155,180],"develop":[156],"three":[158],"had":[161],"past":[163],"history":[164],"Adverse":[171],"events":[172],"over":[173],"grade":[174],"3":[175],"observed.":[181],"CONCLUSION:":[182],"Valacyclovir":[183],"daily":[190],"appears":[191],"to":[192],"effective":[194],"preventing":[196],"well-tolerated":[201],"bortezomib.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}