{"id":"https://openalex.org/W2184430653","doi":null,"title":"Serum adiponectin multimer complexes and liver cancer risk in a large cohort study in Japan.","display_name":"Serum adiponectin multimer complexes and liver cancer risk in a large cohort study in Japan.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2184430653","mag":"2184430653","pmid":"https://pubmed.ncbi.nlm.nih.gov/19469631"},"language":"en","primary_location":{"id":"pmid:19469631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19469631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kazuhiko Kotani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]},{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP","MY"],"is_corresponding":false,"raw_author_name":"Kazuhiko Kotani","raw_affiliation_strings":["Department of Public Health, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp","Universiti Sains Malaysia, Kelantan, Malaysia#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Universiti Sains Malaysia, Kelantan, Malaysia#TAB#","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenji Wakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Kenji Wakai","raw_affiliation_strings":["Universiti sains malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiti sains malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akira Shibata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Akira Shibata","raw_affiliation_strings":["Universiti sains malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiti sains malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuki Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuki Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Itsuro Ogimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Itsuro Ogimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mariko Naito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariko Naito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yoichi Kurozawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoichi Kurozawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Suzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Takesumi Yoshimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takesumi Yoshimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Akiko Tamakoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Tamakoshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1863,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.80733584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"87","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/adiponectin-multimers","display_name":"adiponectin multimers","score":0.9660000205039978},{"id":"https://openalex.org/keywords/liver-cancer-risk","display_name":"liver cancer risk","score":0.7110000252723694},{"id":"https://openalex.org/keywords/low-molecular-weight-adiponectin","display_name":"low molecular weight adiponectin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/high-molecular-weight-adiponectin","display_name":"high molecular weight adiponectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/serum-adiponectin-levels","display_name":"serum adiponectin levels","score":0.7409999966621399},{"id":"https://openalex.org/keywords/japan-collaborative-cohort-study","display_name":"Japan Collaborative Cohort Study","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8808886408805847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7779654264450073},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5815560817718506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5810291767120361},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5785239934921265},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5781960487365723},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5388633012771606},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5270657539367676},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.45868730545043945},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.45691993832588196},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4179130494594574},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.37665069103240967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3439154028892517},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3386226296424866},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33357828855514526},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1992771327495575},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008296","descriptor_name":"Malaysia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19469631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19469631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"pmid:20553088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20553088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Comparative Study"},{"id":"mag:2184430653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19469631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W3554482","https://openalex.org/W1491860558","https://openalex.org/W1839351732","https://openalex.org/W1965070442","https://openalex.org/W1967423421","https://openalex.org/W1971537516","https://openalex.org/W1971634982","https://openalex.org/W1976333736","https://openalex.org/W1976426679","https://openalex.org/W1980790193","https://openalex.org/W1986225008","https://openalex.org/W1991264736","https://openalex.org/W1993256170","https://openalex.org/W2007819868","https://openalex.org/W2010374889","https://openalex.org/W2010933675","https://openalex.org/W2025800033","https://openalex.org/W2027961129","https://openalex.org/W2032775068","https://openalex.org/W2038280977","https://openalex.org/W2038398273","https://openalex.org/W2056742420","https://openalex.org/W2064038438","https://openalex.org/W2065697164","https://openalex.org/W2079146692","https://openalex.org/W2079538512","https://openalex.org/W2080396016","https://openalex.org/W2082818921","https://openalex.org/W2084774262","https://openalex.org/W2088474404","https://openalex.org/W2088876995","https://openalex.org/W2096841845","https://openalex.org/W2105758237","https://openalex.org/W2111674295","https://openalex.org/W2112377527","https://openalex.org/W2113906171","https://openalex.org/W2116254981","https://openalex.org/W2120428357","https://openalex.org/W2120506750","https://openalex.org/W2125289320","https://openalex.org/W2134253678","https://openalex.org/W2141708801","https://openalex.org/W2145093909","https://openalex.org/W2156942076","https://openalex.org/W2158372214","https://openalex.org/W2159690516","https://openalex.org/W2169799551","https://openalex.org/W2400241211","https://openalex.org/W2406999028","https://openalex.org/W2409864461","https://openalex.org/W2411969570","https://openalex.org/W2443358478","https://openalex.org/W2473381352"],"related_works":["https://openalex.org/W2116489995","https://openalex.org/W7096342610","https://openalex.org/W1988963232","https://openalex.org/W2107920900","https://openalex.org/W2980004969","https://openalex.org/W2030586422","https://openalex.org/W2107185209","https://openalex.org/W3109665042","https://openalex.org/W7014847401","https://openalex.org/W2103432497"],"abstract_inverted_index":{"Evidence":[0],"suggests":[1],"a":[2,69,194],"link":[3],"between":[4,43],"adiponectin,":[5,15],"an":[6,112],"adipocytokine,":[7],"and":[8,23,46,61,104,153,157,172,200],"liver":[9,47,55,96,197],"tumorigenesis.":[10],"Different":[11],"multimer":[12,203],"complexes":[13],"of":[14,40,71,101,123,135,187,196],"with":[16,37,131,202],"low-molecular":[17],"weight":[18,21,25],"(LMW),":[19],"middle-molecular":[20],"(MMW)":[22],"high-molecular":[24],"(HMW),":[26],"may":[27,191,205],"have":[28,139],"different":[29],"roles.":[30],"Therefore":[31],"the":[32,38,72,85,120,128,132,145],"present":[33],"study":[34,53],"was":[35,66,95],"performed":[36],"aim":[39],"assessing":[41],"associations":[42],"these":[44],"multimers":[45,125],"cancer":[48,56,97,198],"development.":[49],"A":[50],"nested":[51],"case-control":[52],"(59":[54],"cases":[57],"[mean":[58],"age=63.5":[59],"years]":[60],"334":[62],"controls":[63],"[62.7":[64],"years])":[65],"conducted":[67],"as":[68],"part":[70],"Japan":[73],"Collaborative":[74],"Cohort":[75],"(JACC)":[76],"Study":[77],"recruiting":[78],"healthy":[79],"participants,":[80],"aged":[81],"40-79":[82],"years,":[83],"for":[84,150,159],"follow-up":[86],"period":[87],"from":[88],"1988-1990":[89],"to":[90,138,193],"1999.":[91],"The":[92],"end":[93],"point":[94],"occurrence/death.":[98],"Serum":[99],"levels":[100,122],"HMW,":[102],"MMW":[103],"LMW":[105,136,189],"adiponectin":[106,124,190],"were":[107],"determined":[108],"at":[109,183],"baseline":[110],"using":[111],"ELISA":[113],"assay.":[114],"Multivariate-adjusted":[115],"logistic":[116],"regression":[117],"analyses":[118],"comparing":[119],"tertile":[121],"showed":[126],"that":[127],"groups":[129],"stratified":[130],"highest":[133],"percentage":[134],"tended":[137],"lower":[140],"odds":[141],"ratios":[142],"(ORs)":[143],"than":[144],"lowest":[146],"group":[147],"(OR":[148],"adjusted":[149,158],"sex,":[151,160],"age":[152],"area=0.54":[154],"[95%CI:":[155,176],"0.26-1.11]":[156],"age,":[161],"area,":[162],"body":[163],"mass":[164],"index,":[165],"smoking,":[166],"alcohol,":[167],"coffee":[168],"consumption,":[169],"diabetes":[170],"history":[171],"HCV-antibody":[173],"positivity":[174],"=0.50":[175],"0.22-1.15]),":[177],"albeit":[178],"without":[179],"statistical":[180],"significance":[181],"(set":[182],"p<0.05).":[184],"Higher":[185],"percentages":[186],"circulating":[188],"lead":[192],"reduction":[195],"risk":[199],"relationships":[201],"composition":[204],"merit":[206],"further":[207],"study.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
