{"id":"https://openalex.org/W2184415129","doi":"https://doi.org/10.2478/abm-2010-0045","title":"The role of metabolic acidosis in chronic kidney diseases","display_name":"The role of metabolic acidosis in chronic kidney diseases","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2184415129","doi":"https://doi.org/10.2478/abm-2010-0045","mag":"2184415129"},"language":"en","primary_location":{"id":"doi:10.2478/abm-2010-0045","doi":"https://doi.org/10.2478/abm-2010-0045","is_oa":true,"landing_page_url":"https://doi.org/10.2478/abm-2010-0045","pdf_url":"https://www.sciendo.com/pdf/10.2478/abm-2010-0045","source":{"id":"https://openalex.org/S37617766","display_name":"Asian Biomedicine","issn_l":"1875-855X","issn":["1875-855X","1905-7415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319385","host_organization_name":"Chulalongkorn University","host_organization_lineage":["https://openalex.org/P4310319385"],"host_organization_lineage_names":["Chulalongkorn University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciendo.com/pdf/10.2478/abm-2010-0045","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105529280","display_name":"James C.M. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1334536514","display_name":"Maine Medical Center","ror":"https://ror.org/03g5f5777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334536514"]},{"id":"https://openalex.org/I4210123774","display_name":"Maine Medical Center","ror":"https://ror.org/034c1gc25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774"]},{"id":"https://openalex.org/I4210157102","display_name":"Barbara Bush Children\u2019s Hospital","ror":"https://ror.org/04pd4jr17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210157102"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James C. M. Chan","raw_affiliation_strings":["Department of Pediatrics, University of Vermont, The Barbara Bush Children\u2019s Hospital, Maine Medical Center, Portland, Maine 04102-3175, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Vermont, The Barbara Bush Children\u2019s Hospital, Maine Medical Center, Portland, Maine 04102-3175, USA","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I1334536514","https://openalex.org/I4210123774","https://openalex.org/I4210157102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5105529280"],"corresponding_institution_ids":["https://openalex.org/I111236770","https://openalex.org/I1334536514","https://openalex.org/I4210123774","https://openalex.org/I4210157102"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23094395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"3","first_page":"367","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12806","display_name":"Ocean Acidification Effects and Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1910","display_name":"Oceanography"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/acid-base-physiology","display_name":"acid-base physiology","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endogenous-acid-production","display_name":"endogenous acid production","score":0.9549999833106995},{"id":"https://openalex.org/keywords/net-acid-excretion","display_name":"net acid excretion","score":0.9599999785423279},{"id":"https://openalex.org/keywords/growth","display_name":"growth","score":0.3919999897480011},{"id":"https://openalex.org/keywords/patient-noncompliance","display_name":"patient noncompliance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/acidosis-correction","display_name":"acidosis correction","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.8352934122085571},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.7739437818527222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7285995483398438},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6626033186912537},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6242389678955078},{"id":"https://openalex.org/C3018683220","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal disease","level":3,"score":0.4279305636882782},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4057736396789551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34898608922958374}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2478/abm-2010-0045","doi":"https://doi.org/10.2478/abm-2010-0045","is_oa":true,"landing_page_url":"https://doi.org/10.2478/abm-2010-0045","pdf_url":"https://www.sciendo.com/pdf/10.2478/abm-2010-0045","source":{"id":"https://openalex.org/S37617766","display_name":"Asian Biomedicine","issn_l":"1875-855X","issn":["1875-855X","1905-7415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319385","host_organization_name":"Chulalongkorn University","host_organization_lineage":["https://openalex.org/P4310319385"],"host_organization_lineage_names":["Chulalongkorn University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Biomedicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2478/abm-2010-0045","doi":"https://doi.org/10.2478/abm-2010-0045","is_oa":true,"landing_page_url":"https://doi.org/10.2478/abm-2010-0045","pdf_url":"https://www.sciendo.com/pdf/10.2478/abm-2010-0045","source":{"id":"https://openalex.org/S37617766","display_name":"Asian Biomedicine","issn_l":"1875-855X","issn":["1875-855X","1905-7415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319385","host_organization_name":"Chulalongkorn University","host_organization_lineage":["https://openalex.org/P4310319385"],"host_organization_lineage_names":["Chulalongkorn University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2184415129.pdf","grobid_xml":"https://content.openalex.org/works/W2184415129.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W92965314","https://openalex.org/W177454604","https://openalex.org/W1871937327","https://openalex.org/W1969501963","https://openalex.org/W1970319738","https://openalex.org/W1977645780","https://openalex.org/W1981624500","https://openalex.org/W1984327286","https://openalex.org/W1988178572","https://openalex.org/W1988492227","https://openalex.org/W1991489045","https://openalex.org/W1992735938","https://openalex.org/W1994601225","https://openalex.org/W1997894105","https://openalex.org/W2008821028","https://openalex.org/W2011638954","https://openalex.org/W2015138229","https://openalex.org/W2035391294","https://openalex.org/W2037982936","https://openalex.org/W2055190515","https://openalex.org/W2057808857","https://openalex.org/W2069445515","https://openalex.org/W2088198129","https://openalex.org/W2106867463","https://openalex.org/W2139989191","https://openalex.org/W2154732343","https://openalex.org/W2169648156","https://openalex.org/W2170831281","https://openalex.org/W2177682625","https://openalex.org/W2341277428","https://openalex.org/W2399028133","https://openalex.org/W2409311472","https://openalex.org/W3161474904"],"related_works":["https://openalex.org/W2467477279","https://openalex.org/W2941940781","https://openalex.org/W1967851000","https://openalex.org/W2970777131","https://openalex.org/W2186894187","https://openalex.org/W4205300000","https://openalex.org/W4249863496","https://openalex.org/W2127160530","https://openalex.org/W2100306933","https://openalex.org/W2950937924"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,26,41,46,64,87,113,127],"objectives:":[3],"This":[4],"review":[5],"focuses":[6],"on":[7,50,71,104,111],"three":[8,78],"areas,":[9],"basic":[10],"acid-base":[11],"physiology":[12,74],"especially":[13],"concerning":[14],"hydrogen":[15],"ion":[16],"balance,":[17],"development":[18,96],"of":[19,29,97,107,123,138,155],"acidosis":[20,51,99,110,139],"in":[21,52,83,100,140],"chronic":[22,108,141],"kidney":[23,142],"disease":[24,143],"(CKD),":[25],"the":[27,68,76,95,105,120,156],"consequences":[28,106],"acidosis.":[30],"We":[31],"highlight":[32],"what":[33,37,42],"is":[34,38,43,149,167],"well":[35],"established,":[36],"less":[39],"certain,":[40],"unknown.":[44],"Method":[45],"results:":[47],"The":[48,80,136,147],"literature":[49],"CKD":[53],"were":[54,91],"searched":[55],"from":[56],"2004":[57],"to":[58,66,131,160],"2010":[59],"utilizing":[60],"PubMed,":[61],"Google":[62],"Scholar,":[63],"Ovid":[65],"augment":[67],"classic":[69],"work":[70],"acid":[72,85,89],"base":[73],"over":[75],"past":[77],"decades.":[79],"original":[81],"research":[82],"endogenous":[84],"production":[86],"net":[88],"excretion":[90],"reviewed.":[92],"Touching":[93],"upon":[94],"metabolic":[98,109],"CKD,":[101],"we":[102,118],"focused":[103],"growth":[112],"other":[114],"important":[115],"variables.":[116],"Finally,":[117],"recognize":[119],"significant":[121],"issue":[122],"patients\u2019":[124],"medical":[125],"non-compliance":[126,153],"presented":[128],"treatment":[129],"strategy":[130],"counter":[132],"this":[133],"problem.":[134],"Conclusion:":[135],"correction":[137],"needs":[144,159],"no":[145],"advocacy.":[146],"case":[148],"made":[150],"conclusively.":[151],"Patient":[152],"because":[154],"medication":[157],"that":[158],"be":[161],"taken":[162],"several":[163],"times":[164],"a":[165,168],"day":[166],"problem,":[169],"requiring":[170],"due":[171],"diligence.":[172]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}