{"id":"https://openalex.org/W2184407568","doi":null,"title":"Evaluation of Iyengariastellata for its hypolipidemic and hepatoprotective activity.","display_name":"Evaluation of Iyengariastellata for its hypolipidemic and hepatoprotective activity.","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2184407568","mag":"2184407568","pmid":"https://pubmed.ncbi.nlm.nih.gov/25362602"},"language":"en","primary_location":{"id":"pmid:25362602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25362602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002167280","display_name":"Bushra Riaz","orcid":"https://orcid.org/0009-0000-1925-4447","observed_orcids":["https://orcid.org/0009-0000-1925-4447","https://orcid.org/0000-0002-1045-348X"]},"institutions":[{"id":"https://openalex.org/I18718515","display_name":"Jinnah University for Women","ror":"https://ror.org/056zv5g90","country_code":"PK","type":"education","lineage":["https://openalex.org/I18718515"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Bushra Riaz","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Karachi, Pakistan","institution_ids":["https://openalex.org/I18718515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113633897","display_name":"Rahila Najam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rahila Najam","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Humera Anser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Humera Anser","raw_affiliation_strings":["Department of Pharmacology, Jinnah College of Pharmacy, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Jinnah College of Pharmacy, Karachi, Pakistan","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Muhammad Shaiq Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Shaiq Ali","raw_affiliation_strings":["Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7782,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.7005215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"27","issue":"6","first_page":"1775","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10643","display_name":"Marine and coastal plant biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1910","display_name":"Oceanography"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brown-algae","display_name":"brown algae","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8190000057220459},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.972000002861023},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.7540000081062317},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/seaweed-extract","display_name":"seaweed extract","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.39800000190734863},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.7176196575164795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5812218189239502},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5718130469322205},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.5592599511146545},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.551832914352417},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.5218806862831116},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5214312076568604},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.48965340852737427},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4841404855251312},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.47225111722946167},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.4625842273235321},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4164777100086212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35164692997932434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25442469120025635},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2356013059616089},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.20048782229423523},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.06211978197097778},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012624","descriptor_name":"Seaweed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25362602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25362602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"mag:2184407568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25362602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W626863681","https://openalex.org/W1462754900","https://openalex.org/W1603723025","https://openalex.org/W1956628960","https://openalex.org/W1967139864","https://openalex.org/W2025446985","https://openalex.org/W2031899956","https://openalex.org/W2031913917","https://openalex.org/W2047922146","https://openalex.org/W2063820151","https://openalex.org/W2077217530","https://openalex.org/W2083109340","https://openalex.org/W2094768566","https://openalex.org/W2118728926","https://openalex.org/W2127510700","https://openalex.org/W2140209240","https://openalex.org/W2140965288","https://openalex.org/W2160698761","https://openalex.org/W2169509583","https://openalex.org/W2337032743","https://openalex.org/W2409761207","https://openalex.org/W2740401558","https://openalex.org/W3021092633","https://openalex.org/W3147953463","https://openalex.org/W3156130246","https://openalex.org/W4318599934"],"related_works":["https://openalex.org/W2140209240","https://openalex.org/W2074420327","https://openalex.org/W4400386235","https://openalex.org/W2017119485","https://openalex.org/W2080829406","https://openalex.org/W799058397","https://openalex.org/W2042498830","https://openalex.org/W3013370795","https://openalex.org/W1966990918","https://openalex.org/W1630415683"],"abstract_inverted_index":{"Cholesterol":[0],"is":[1,40,112,127],"believed":[2],"to":[3,20,41,68,152],"be":[4,149],"the":[5,10,48,138,143,145],"major":[6],"regulator":[7],"involved":[8],"in":[9,58,95],"formation":[11],"and":[12,44,61,73,130],"progression":[13],"of":[14,28,37,47,54,116,121,140,142],"atheroma":[15],"plaque.":[16],"Seaweeds":[17],"are":[18],"known":[19],"possess":[21],"enormous":[22],"biological":[23],"activities.":[24],"They":[25],"contain":[26],"variety":[27],"active":[29],"constituents,":[30],"which":[31,105],"have":[32],"pharmacological":[33],"significance.":[34],"The":[35,90],"objective":[36],"this":[38],"study":[39],"explore":[42],"hypolipidemic":[43,134],"hepatoprotective":[45],"activities":[46],"brown":[49],"seaweed":[50,55,144],"Iyengariastellata.":[51],"Ethanolic":[52],"extract":[53],"was":[56,106],"suspended":[57],"distilled":[59],"water":[60],"administered":[62],"orally":[63],"at":[64],"10mg/200g":[65],"body":[66],"weight":[67],"rabbits":[69],"for":[70],"30":[71],"days":[72],"total":[74],"lipid":[75,96],"level,":[76],"cholesterol,":[77],"triglycerides,":[78],"HDL,":[79],"LDL,":[80],"VLDL,":[81],"alkaline":[82],"phosphatase,":[83],"SGPT,":[84],"SGOT,":[85],"Gamma":[86],"GT":[87],"were":[88],"assessed.":[89],"results":[91],"showed":[92],"overall":[93],"decrease":[94],"profile":[97],"whereas":[98],"Iyengariastellata":[99,125],"increased":[100],"liver":[101,117,146,154],"enzymes":[102,147],"except":[103],"SGPT":[104,111,122],"decreased":[107,119],"highly":[108],"significantly,":[109],"since":[110],"more":[113],"specific":[114],"indicator":[115],"injury,":[118],"value":[120],"indicates":[123],"that":[124],"toxicity":[126],"less":[128],"severe":[129],"reversible":[131],"with":[132],"marked":[133],"effect,":[135],"but":[136],"during":[137],"course":[139],"ingestion":[141],"must":[148],"carefully":[150],"monitored":[151],"ensure":[153],"safety.":[155]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}