{"id":"https://openalex.org/W2184362196","doi":null,"title":"Improving Alzheimer's disease outcomes in Down's syndrome","display_name":"Improving Alzheimer's disease outcomes in Down's syndrome","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2184362196","mag":"2184362196"},"language":"en","primary_location":{"id":"mag:2184362196","doi":null,"is_oa":false,"landing_page_url":"https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(11)61929-6.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029939975","display_name":"Liv Bente Romundstad","orcid":"https://orcid.org/0000-0003-3259-3915","observed_orcids":["https://orcid.org/0000-0003-3259-3915"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Liv Bente Romundstad","raw_affiliation_strings":["Norwegian University of Science and Technology"],"raw_orcid":"https://orcid.org/0000-0003-3259-3915","affiliations":[{"raw_affiliation_string":"Norwegian University of Science and Technology","institution_ids":["https://openalex.org/I204778367"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029939975"],"corresponding_institution_ids":["https://openalex.org/I204778367"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.890999972820282},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.5989999771118164},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"embryo transfer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/multiple-births","display_name":"multiple births","score":0.6959999799728394},{"id":"https://openalex.org/keywords/twin-pregnancy","display_name":"twin pregnancy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/predictive-model","display_name":"prediction model","score":0.5130000114440918},{"id":"https://openalex.org/keywords/patient-information","display_name":"patient information","score":0.4620000123977661},{"id":"https://openalex.org/keywords/public-funding","display_name":"government funding","score":0.7319999933242798},{"id":"https://openalex.org/keywords/embryo-cryopreservation","display_name":"embryo cryopreservation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/pregnancy-outcomes","display_name":"pregnancy outcomes","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6543768048286438},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.5547223091125488},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5130147337913513},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48680970072746277},{"id":"https://openalex.org/C2776210078","wikidata":"https://www.wikidata.org/wiki/Q351870","display_name":"Reproductive medicine","level":3,"score":0.4180740416049957},{"id":"https://openalex.org/C2778279030","wikidata":"https://www.wikidata.org/wiki/Q1543380","display_name":"Live birth","level":3,"score":0.4114048182964325},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3613341748714447},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3504769802093506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09886717796325684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184362196","doi":null,"is_oa":false,"landing_page_url":"https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(11)61929-6.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1997271339","https://openalex.org/W1997600737","https://openalex.org/W2019980747","https://openalex.org/W2027752708","https://openalex.org/W2101710078","https://openalex.org/W2138675442","https://openalex.org/W2145846347","https://openalex.org/W2161348707","https://openalex.org/W2166995862","https://openalex.org/W2586506530"],"related_works":["https://openalex.org/W2087998520","https://openalex.org/W2098077080","https://openalex.org/W1964975105","https://openalex.org/W2166249698","https://openalex.org/W2557306326","https://openalex.org/W4385330112","https://openalex.org/W1985662063","https://openalex.org/W2312623107","https://openalex.org/W4231721369","https://openalex.org/W3092549136"],"abstract_inverted_index":{"8can":[0],"be":[1,11,28,69,106,177],"adopted":[2],"elsewhere":[3],"is":[4,127],"worthy":[5],"of":[6,33,59,97,112,120,142,159,164,174],"consideration.":[7],"Medical":[8],"care":[9],"should":[10,27,89],"guided":[12],"by":[13],"the":[14,19,110,140,153,169,172],"best":[15],"available":[16],"evidence,":[17],"and":[18,77,124,145],"decision":[20,58],"to":[21,61,86,108,122,131],"transfer":[22,62],"more":[23,92],"than":[24,93],"one":[25,63,94,179],"embryo":[26,148],"based":[29,70],"on":[30,71],"an":[31],"assessment":[32],"each":[34],"patient\u2019s":[35],"prognostic":[36,101],"factors,":[37],"including":[38],"age.":[39],"A":[40,162],"prediction":[41],"model":[42],"for":[43],"outcomes":[44],"after":[45,115],"assisted":[46,116],"conception":[47],"12,13":[48],"has":[49],"not":[50],"yet":[51],"been":[52],"universally":[53],"adopted.":[54],"The":[55,118],"fi":[56],"nal":[57],"whether":[60],"or":[64,83,99],"two":[65],"embryos":[66],"should,":[67],"therefore,":[68],"a":[72,137,183],"cooperative":[73],"approach":[74],"between":[75],"embryologists":[76],"clinicians,":[78],"although":[79],"patients":[80,123],"with":[81],"medical":[82],"obstetric":[84],"contraindications":[85],"twin":[87],"pregnancies":[88],"receive":[90],"no":[91],"embryo,":[95],"irrespective":[96],"age":[98],"other":[100],"factors.":[102],"Several":[103],"strategies":[104],"can":[105,135],"used":[107],"lower":[109],"risk":[111],"multiple":[113],"births":[114],"conception.":[117],"provision":[119],"information":[121],"health-care":[125],"providers":[126],"essential.":[128],"Public":[129],"funding":[130],"cover":[132],"treatment":[133],"costs":[134],"facilitate":[136],"reduction":[138],"in":[139,147],"number":[141],"transferred":[143],"embryos,":[144],"improvements":[146],"freezing":[149],"techniques":[150],"will":[151,167,176],"increase":[152,168],"cumulative":[154],"pregnancy":[155],"rate":[156],"per":[157],"cycle":[158],"oocyte":[160],"retrieval.":[161],"combination":[163],"these":[165],"factors":[166],"likelihood":[170],"that":[171],"outcome":[173],"interest":[175],"achieved:":[178],"healthy":[180],"baby":[181],"at":[182],"time.":[184]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}