{"id":"https://openalex.org/W2184360024","doi":null,"title":"Role of the p62 Protein in the Formation of Neuropathological Cytoplasmic Inclusions","display_name":"Role of the p62 Protein in the Formation of Neuropathological Cytoplasmic Inclusions","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2184360024","mag":"2184360024"},"language":"en","primary_location":{"id":"mag:2184360024","doi":null,"is_oa":false,"landing_page_url":"https://epublications.uef.fi/pub/urn_isbn_951-27-0200-2/urn_isbn_951-27-0200-2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022598643","display_name":"Erkki Kuusisto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Erkki Kuusisto","raw_affiliation_strings":["University of Eastern Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022598643"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":null,"apc_paid":null,"fwci":1.4124,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7822768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cytoplasmic-inclusions","display_name":"cytoplasmic inclusions","score":0.925000011920929},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5740000009536743},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8100000023841858},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8970000147819519},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.3370000123977661},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.6579999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/prosurvival-signaling","display_name":"survival signaling","score":0.5509999990463257},{"id":"https://openalex.org/keywords/inclusion-formation","display_name":"inclusion formation","score":0.3100000023841858},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5130000114440918},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.6029999852180481},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pick-s-disease","display_name":"Pick's disease","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.9033149480819702},{"id":"https://openalex.org/C36124564","wikidata":"https://www.wikidata.org/wiki/Q1286842","display_name":"Cytoplasmic inclusion","level":3,"score":0.7049757838249207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6490439176559448},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6272116303443909},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5543034076690674},{"id":"https://openalex.org/C203750385","wikidata":"https://www.wikidata.org/wiki/Q1308970","display_name":"Inclusion bodies","level":4,"score":0.5174027681350708},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4917154610157013},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46615561842918396},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.4302195906639099},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.41415128111839294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40994125604629517},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3526362180709839},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33068370819091797},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.33062630891799927},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.2676941156387329},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18553540110588074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15749803185462952},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1330762803554535},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184360024","doi":null,"is_oa":false,"landing_page_url":"https://epublications.uef.fi/pub/urn_isbn_951-27-0200-2/urn_isbn_951-27-0200-2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":454,"referenced_works":["https://openalex.org/W1718725","https://openalex.org/W1734661","https://openalex.org/W8017007","https://openalex.org/W36139474","https://openalex.org/W37351408","https://openalex.org/W69591616","https://openalex.org/W79270160","https://openalex.org/W113231398","https://openalex.org/W135141196","https://openalex.org/W139984142","https://openalex.org/W173382140","https://openalex.org/W179780591","https://openalex.org/W196397464","https://openalex.org/W248039357","https://openalex.org/W283353572","https://openalex.org/W345305052","https://openalex.org/W1237068170","https://openalex.org/W1249061998","https://openalex.org/W1480786153","https://openalex.org/W1482452656","https://openalex.org/W1483007279","https://openalex.org/W1487645896","https://openalex.org/W1494109356","https://openalex.org/W1496790952","https://openalex.org/W1504584187","https://openalex.org/W1511517753","https://openalex.org/W1514640482","https://openalex.org/W1520171546","https://openalex.org/W1521854746","https://openalex.org/W1525659758","https://openalex.org/W1527671059","https://openalex.org/W1528219518","https://openalex.org/W1532188427","https://openalex.org/W1534346139","https://openalex.org/W1534557128","https://openalex.org/W1538925586","https://openalex.org/W1544371346","https://openalex.org/W1544396026","https://openalex.org/W1552943795","https://openalex.org/W1556008598","https://openalex.org/W1556490889","https://openalex.org/W1558608994","https://openalex.org/W1564414547","https://openalex.org/W1572679174","https://openalex.org/W1582229352","https://openalex.org/W1590029920","https://openalex.org/W1591724033","https://openalex.org/W1600934558","https://openalex.org/W1601052838","https://openalex.org/W1602917883","https://openalex.org/W1605328378","https://openalex.org/W1618846043","https://openalex.org/W1620862744","https://openalex.org/W1630502818","https://openalex.org/W1822020178","https://openalex.org/W1825827930","https://openalex.org/W1829394502","https://openalex.org/W1837586904","https://openalex.org/W1848907877","https://openalex.org/W1851562605","https://openalex.org/W1877873625","https://openalex.org/W1896219833","https://openalex.org/W1930159471","https://openalex.org/W1935894920","https://openalex.org/W1964927978","https://openalex.org/W1965111978","https://openalex.org/W1965217223","https://openalex.org/W1965497520","https://openalex.org/W1965708122","https://openalex.org/W1966130903","https://openalex.org/W1966730374","https://openalex.org/W1966903404","https://openalex.org/W1967285029","https://openalex.org/W1967380123","https://openalex.org/W1967776802","https://openalex.org/W1967931222","https://openalex.org/W1968905573","https://openalex.org/W1968942251","https://openalex.org/W1968957266","https://openalex.org/W1969034370","https://openalex.org/W1969979382","https://openalex.org/W1970122257","https://openalex.org/W1970596302","https://openalex.org/W1972172786","https://openalex.org/W1972522869","https://openalex.org/W1973295647","https://openalex.org/W1973652068","https://openalex.org/W1973774127","https://openalex.org/W1975111736","https://openalex.org/W1975375906","https://openalex.org/W1975481676","https://openalex.org/W1975596414","https://openalex.org/W1976067097","https://openalex.org/W1976148085","https://openalex.org/W1976578056","https://openalex.org/W1977067529","https://openalex.org/W1977237836","https://openalex.org/W1977383752","https://openalex.org/W1977846417","https://openalex.org/W1979268652","https://openalex.org/W1979286020","https://openalex.org/W1979780091","https://openalex.org/W1979915207","https://openalex.org/W1979945225","https://openalex.org/W1979976015","https://openalex.org/W1980493562","https://openalex.org/W1980768099","https://openalex.org/W1982487434","https://openalex.org/W1982928559","https://openalex.org/W1983374628","https://openalex.org/W1983632956","https://openalex.org/W1983768810","https://openalex.org/W1983904065","https://openalex.org/W1984296170","https://openalex.org/W1985002125","https://openalex.org/W1986042913","https://openalex.org/W1986413832","https://openalex.org/W1986625112","https://openalex.org/W1987012898","https://openalex.org/W1988146888","https://openalex.org/W1988367902","https://openalex.org/W1989498124","https://openalex.org/W1989999317","https://openalex.org/W1990573749","https://openalex.org/W1991130856","https://openalex.org/W1991241547","https://openalex.org/W1991631628","https://openalex.org/W1991738330","https://openalex.org/W1992671570","https://openalex.org/W1993282326","https://openalex.org/W1994282166","https://openalex.org/W1994926763","https://openalex.org/W1995694098","https://openalex.org/W1995771017","https://openalex.org/W1996715055","https://openalex.org/W1997064986","https://openalex.org/W1997369314","https://openalex.org/W1997818885","https://openalex.org/W1997858645","https://openalex.org/W1998128283","https://openalex.org/W1998948011","https://openalex.org/W1999680191","https://openalex.org/W1999895781","https://openalex.org/W2001264483","https://openalex.org/W2001407922","https://openalex.org/W2002417285","https://openalex.org/W2002506451","https://openalex.org/W2003094694","https://openalex.org/W2003247108","https://openalex.org/W2003377881","https://openalex.org/W2003589106","https://openalex.org/W2003647788","https://openalex.org/W2003985105","https://openalex.org/W2004027050","https://openalex.org/W2004166388","https://openalex.org/W2004676396","https://openalex.org/W2004844986","https://openalex.org/W2005622137","https://openalex.org/W2006051211","https://openalex.org/W2006376420","https://openalex.org/W2006615448","https://openalex.org/W2007472518","https://openalex.org/W2008899984","https://openalex.org/W2009125409","https://openalex.org/W2009556855","https://openalex.org/W2009890105","https://openalex.org/W2009945323","https://openalex.org/W2010783015","https://openalex.org/W2011308707","https://openalex.org/W2011381918","https://openalex.org/W2011881593","https://openalex.org/W2012781495","https://openalex.org/W2013339424","https://openalex.org/W2014300038","https://openalex.org/W2014485936","https://openalex.org/W2014670147","https://openalex.org/W2015522247","https://openalex.org/W2015860144","https://openalex.org/W2016816471","https://openalex.org/W2016863672","https://openalex.org/W2016974059","https://openalex.org/W2017256678","https://openalex.org/W2018505720","https://openalex.org/W2018633688","https://openalex.org/W2018661127","https://openalex.org/W2018983416","https://openalex.org/W2019364582","https://openalex.org/W2019761433","https://openalex.org/W2020057468","https://openalex.org/W2020233019","https://openalex.org/W2020600076","https://openalex.org/W2020697171","https://openalex.org/W2021017365","https://openalex.org/W2021134013","https://openalex.org/W2021155980","https://openalex.org/W2021883084","https://openalex.org/W2021977313","https://openalex.org/W2021999649","https://openalex.org/W2022325384","https://openalex.org/W2024041381","https://openalex.org/W2024449044","https://openalex.org/W2024546162","https://openalex.org/W2025810246","https://openalex.org/W2026544197","https://openalex.org/W2026851735","https://openalex.org/W2027649342","https://openalex.org/W2028395847","https://openalex.org/W2029000167","https://openalex.org/W2029543048","https://openalex.org/W2030929103","https://openalex.org/W2031209928","https://openalex.org/W2031612618","https://openalex.org/W2031765503","https://openalex.org/W2031864556","https://openalex.org/W2032356780","https://openalex.org/W2032797457","https://openalex.org/W2032817175","https://openalex.org/W2032888222","https://openalex.org/W2033262835","https://openalex.org/W2033991658","https://openalex.org/W2034447651","https://openalex.org/W2035232504","https://openalex.org/W2036029971","https://openalex.org/W2036123807","https://openalex.org/W2037158293","https://openalex.org/W2037454778","https://openalex.org/W2037792829","https://openalex.org/W2037948191","https://openalex.org/W2038729585","https://openalex.org/W2039137539","https://openalex.org/W2039191388","https://openalex.org/W2039425118","https://openalex.org/W2039468514","https://openalex.org/W2039629489","https://openalex.org/W2039885900","https://openalex.org/W2040253875","https://openalex.org/W2040351396","https://openalex.org/W2041058051","https://openalex.org/W2041655987","https://openalex.org/W2042290382","https://openalex.org/W2044968967","https://openalex.org/W2044974101","https://openalex.org/W2046014998","https://openalex.org/W2046431926","https://openalex.org/W2047584213","https://openalex.org/W2048897966","https://openalex.org/W2049032266","https://openalex.org/W2050512725","https://openalex.org/W2050748701","https://openalex.org/W2050786534","https://openalex.org/W2051756930","https://openalex.org/W2052100703","https://openalex.org/W2052590422","https://openalex.org/W2052742260","https://openalex.org/W2053097655","https://openalex.org/W2053116497","https://openalex.org/W2053383702","https://openalex.org/W2053764851","https://openalex.org/W2054223500","https://openalex.org/W2054848243","https://openalex.org/W2056001326","https://openalex.org/W2056022228","https://openalex.org/W2056811680","https://openalex.org/W2056990175","https://openalex.org/W2057385777","https://openalex.org/W2057654544","https://openalex.org/W2057801189","https://openalex.org/W2058295483","https://openalex.org/W2058570072","https://openalex.org/W2059190157","https://openalex.org/W2059382925","https://openalex.org/W2059737503","https://openalex.org/W2060391279","https://openalex.org/W2060526494","https://openalex.org/W2061478357","https://openalex.org/W2061601211","https://openalex.org/W2061799837","https://openalex.org/W2061995199","https://openalex.org/W2063015800","https://openalex.org/W2063358955","https://openalex.org/W2063407739","https://openalex.org/W2063960864","https://openalex.org/W2064080881","https://openalex.org/W2064859643","https://openalex.org/W2065619274","https://openalex.org/W2067137072","https://openalex.org/W2069719894","https://openalex.org/W2071243806","https://openalex.org/W2072084253","https://openalex.org/W2072254915","https://openalex.org/W2072282880","https://openalex.org/W2073076870","https://openalex.org/W2073135755","https://openalex.org/W2073449985","https://openalex.org/W2073974661","https://openalex.org/W2074180389","https://openalex.org/W2074649216","https://openalex.org/W2075997185","https://openalex.org/W2076163606","https://openalex.org/W2076508298","https://openalex.org/W2076935230","https://openalex.org/W2077044335","https://openalex.org/W2077422298","https://openalex.org/W2077481531","https://openalex.org/W2078427707","https://openalex.org/W2079003999","https://openalex.org/W2080435498","https://openalex.org/W2080765656","https://openalex.org/W2081106067","https://openalex.org/W2081355012","https://openalex.org/W2082515665","https://openalex.org/W2082740119","https://openalex.org/W2083002238","https://openalex.org/W2083301989","https://openalex.org/W2083369773","https://openalex.org/W2083592950","https://openalex.org/W2083604100","https://openalex.org/W2083842919","https://openalex.org/W2084118479","https://openalex.org/W2084121216","https://openalex.org/W2086539466","https://openalex.org/W2086751197","https://openalex.org/W2086857730","https://openalex.org/W2087389265","https://openalex.org/W2087538939","https://openalex.org/W2088075448","https://openalex.org/W2088481573","https://openalex.org/W2088913270","https://openalex.org/W2089386161","https://openalex.org/W2089491263","https://openalex.org/W2089519022","https://openalex.org/W2089560975","https://openalex.org/W2090926709","https://openalex.org/W2091204354","https://openalex.org/W2091465419","https://openalex.org/W2091820232","https://openalex.org/W2093221129","https://openalex.org/W2093861673","https://openalex.org/W2094398065","https://openalex.org/W2094675227","https://openalex.org/W2094939924","https://openalex.org/W2095268950","https://openalex.org/W2095359135","https://openalex.org/W2095436835","https://openalex.org/W2096410114","https://openalex.org/W2097965815","https://openalex.org/W2098004479","https://openalex.org/W2098257571","https://openalex.org/W2099685145","https://openalex.org/W2100246616","https://openalex.org/W2103829129","https://openalex.org/W2105729193","https://openalex.org/W2107451956","https://openalex.org/W2109373229","https://openalex.org/W2109628664","https://openalex.org/W2109956926","https://openalex.org/W2110580010","https://openalex.org/W2110888808","https://openalex.org/W2113034786","https://openalex.org/W2114358785","https://openalex.org/W2114873132","https://openalex.org/W2116449089","https://openalex.org/W2116552323","https://openalex.org/W2116598203","https://openalex.org/W2116807721","https://openalex.org/W2117626437","https://openalex.org/W2118518385","https://openalex.org/W2120470436","https://openalex.org/W2120867735","https://openalex.org/W2121506107","https://openalex.org/W2121963977","https://openalex.org/W2122128537","https://openalex.org/W2123056519","https://openalex.org/W2123431154","https://openalex.org/W2125172225","https://openalex.org/W2128049336","https://openalex.org/W2128674001","https://openalex.org/W2128932095","https://openalex.org/W2130466887","https://openalex.org/W2130877162","https://openalex.org/W2131207606","https://openalex.org/W2131256783","https://openalex.org/W2132104987","https://openalex.org/W2133068803","https://openalex.org/W2133272695","https://openalex.org/W2134766199","https://openalex.org/W2134786936","https://openalex.org/W2135387829","https://openalex.org/W2136709809","https://openalex.org/W2136750984","https://openalex.org/W2136800594","https://openalex.org/W2138878035","https://openalex.org/W2141066687","https://openalex.org/W2141583055","https://openalex.org/W2141755885","https://openalex.org/W2144634347","https://openalex.org/W2144734165","https://openalex.org/W2145149844","https://openalex.org/W2145669564","https://openalex.org/W2146729934","https://openalex.org/W2146883699","https://openalex.org/W2148569529","https://openalex.org/W2149472608","https://openalex.org/W2149761960","https://openalex.org/W2150656456","https://openalex.org/W2153439292","https://openalex.org/W2154761807","https://openalex.org/W2156182885","https://openalex.org/W2157262140","https://openalex.org/W2157535220","https://openalex.org/W2157618233","https://openalex.org/W2158118162","https://openalex.org/W2160398747","https://openalex.org/W2160991051","https://openalex.org/W2161807104","https://openalex.org/W2161953596","https://openalex.org/W2163287785","https://openalex.org/W2164065816","https://openalex.org/W2164128098","https://openalex.org/W2165417923","https://openalex.org/W2166789153","https://openalex.org/W2168224573","https://openalex.org/W2168413008","https://openalex.org/W2168619147","https://openalex.org/W2168637323","https://openalex.org/W2189220766","https://openalex.org/W2287631994","https://openalex.org/W2311781118","https://openalex.org/W2314185656","https://openalex.org/W2323918049","https://openalex.org/W2327171315","https://openalex.org/W2327347776","https://openalex.org/W2338476325","https://openalex.org/W2363633697","https://openalex.org/W2372555315","https://openalex.org/W2376181681","https://openalex.org/W2403732318","https://openalex.org/W2404904272","https://openalex.org/W2409606948","https://openalex.org/W2431662375","https://openalex.org/W2432361590","https://openalex.org/W2464397158","https://openalex.org/W2470223656","https://openalex.org/W2488473195","https://openalex.org/W2555395385","https://openalex.org/W2725718031","https://openalex.org/W3006806011","https://openalex.org/W3095728130","https://openalex.org/W3160444400","https://openalex.org/W4249652994","https://openalex.org/W4285719527","https://openalex.org/W4296930794","https://openalex.org/W4296930909","https://openalex.org/W4319308505"],"related_works":["https://openalex.org/W3094900654","https://openalex.org/W2055432326","https://openalex.org/W2081106067","https://openalex.org/W2022812411","https://openalex.org/W1486793962","https://openalex.org/W3022185599","https://openalex.org/W2022512272","https://openalex.org/W2062483430","https://openalex.org/W7096894721","https://openalex.org/W2018346867"],"abstract_inverted_index":{"The":[0,92,298,303,383,417],"pathology":[1,280,362,388],"of":[2,10,33,43,46,61,98,112,115,128,164,170,195,203,207,221,268,281,289,293,305,329,363,385,412,419,425,432,447,454,488],"aging-associated":[3],"neurodegenerative":[4,188,506],"disorders":[5],"typically":[6],"involves":[7],"the":[8,15,58,80,89,96,110,126,132,160,167,193,205,219,230,266,278,287,327,338,345,360,390,423,445,451],"occurrence":[9],"proteinaceous":[11],"cytoplasmic":[12,44,99,347],"inclusions":[13,18,34,100,116,291,348,455,470],"in":[14,21,52,148,187,212,215,225,229,272,315,344,349,379,389,398,450,466],"brain.":[16],"These":[17,436],"are":[19,41,66,86,101,163,438],"seen":[20],"both":[22,312,334],"neurons":[23],"and":[24,63,83,131,144,176,246,249,257,308,320,336,373,405],"glial":[25],"cells,":[26],"affecting":[27],"disease-specific":[28],"cell":[29,70,484],"populations.":[30],"Most":[31],"types":[32,114,453],"associated":[35],"with":[36,200,254,275,422,440],"cognitive":[37],"or":[38,48,158],"movement":[39],"dysfunction":[40,84],"composed":[42],"aggregates":[45],"tau":[47,279,361],"\u03b1-synuclein":[49],"(\u03b1S)":[50],"proteins":[51,142,153,184],"aberrant":[53],"fibrillar":[54],"forms,":[55],"thus":[56],"defining":[57],"disease":[59,295],"groups":[60],"\u201ctauopathies\u201d":[62],"\u201csynucleinopathies\u201d.":[64],"Inclusions":[65],"usually":[67],"accompanied":[68],"by":[69],"loss,":[71],"suggesting":[72],"that":[73,85,109,154,460],"their":[74,146,467],"origin":[75],"is":[76,106,137,456],"closely":[77],"linked":[78],"to":[79,124,139,157,182,277,317,394,482],"neuronal":[81,216],"death":[82],"responsible":[87],"for":[88,475],"clinical":[90],"symptoms.":[91],"molecular":[93],"events":[94],"underlying":[95],"formation":[97,130,424],"poorly":[102],"understood,":[103],"but":[104,351,444],"it":[105,136],"increasingly":[107],"believed":[108],"biogenesis":[111],"different":[113,243],"may":[117,155,471,480],"share":[118],"some":[119],"common":[120],"mechanisms.":[121],"In":[122,151,166,237,263,284,333,359],"order":[123],"elucidate":[125],"mechanisms":[127],"inclusion":[129,502],"elicited":[133],"cellular":[134,177],"reactions,":[135],"necessary":[138],"identify":[140,183],"key":[141],"involved":[143,186],"investigate":[145],"roles":[147],"these":[149,380],"events.":[150],"particular,":[152],"contribute":[156],"regulate":[159],"aggregation":[161,228,415],"process":[162],"interest.":[165],"present":[168,343],"series":[169],"studies,":[171],"a":[172,197,375,395,413,430,433,463],"gene":[173],"array":[174],"approach":[175],"models":[178],"were":[179,261,311],"first":[180],"utilized":[181],"potentially":[185,476],"phenomena":[189],"(study":[190],"I).":[191],"Following":[192],"identification":[194],"p62,":[196],"signaling":[198],"protein":[199,209,227,310,340],"several":[201,441],"features":[202],"interest,":[204],"expression":[206,304],"this":[208],"was":[210,223,270,296,341,352,367],"examined":[211],"neuropathology-mimicking":[213],"conditions":[214,319],"culture.":[217],"Subsequently,":[218],"involvement":[220,449],"p62":[222,269,306,309,339,366,420,448,461,479],"investigated":[224],"disease-associated":[226],"human":[231],"brain":[232,240],"using":[233],"immunohistochemistry":[234],"(studies":[235],"II\u2212IV).":[236],"study":[238,264,285],"II,":[239],"specimens":[241],"from":[242,355],"tauopathies":[244,335],"(Alzheimer":[245],"Pick":[247],"diseases)":[248],"synucleinopathies":[250],"(Parkinson":[251],"disease,":[252,365],"dementia":[253],"Lewy":[255,406,504],"bodies,":[256,404],"multiple":[258],"system":[259],"atrophy)":[260],"examined.":[262],"III,":[265],"incorporation":[267],"studied":[271],"more":[273],"detail":[274],"respect":[276],"Alzheimer":[282,364,496],"disease.":[283],"IV,":[286],"morphogenesis":[288],"\u03b1S-containing":[290],"characteristic":[292],"Parkinson":[294,510],"elucidated.":[297],"main":[299],"findings":[300,437],"were:":[301],"I:":[302],"transcript":[307],"prominently":[313],"upregulated":[314],"response":[316],"pro-apoptotic":[318],"proteasomal":[321],"inhibition.":[322],"This":[323],"upregulation":[324],"might":[325],"indicate":[326],"activation":[328],"survival":[330],"signaling.":[331],"II:":[332],"synucleinopathies,":[337],"copiously":[342],"hallmark":[346],"perikarya":[350],"mostly":[353],"absent":[354],"intraneuritic":[356],"deposits.":[357],"III:":[358],"selectively":[368],"incorporated":[369],"into":[370],"neurofibrillary":[371,508],"tangles":[372],"represented":[374],"relatively":[376],"early":[377],"constituent":[378],"structures.":[381],"IV:":[382],"spectrum":[384],"perikaryal":[386],"\u03b1S":[387,401],"substantia":[391],"nigra":[392],"pointed":[393],"morphogenetic":[396],"sequence":[397],"which":[399],"punctate":[400],"deposits,":[402],"pale":[403],"bodies":[407],"arise":[408],"as":[409,429,458,473],"successive":[410],"stages":[411],"complex":[414],"process.":[416],"engagement":[418],"coincided":[421],"compact":[426],"inclusions,":[427],"possibly":[428],"part":[431],"cytoprotective":[434],"response.":[435],"compatible":[439],"alternative":[442],"interpretations,":[443],"pattern":[446],"various":[452],"viewed":[457],"evidence":[459],"plays":[462],"contributory":[464],"role":[465],"formation.":[468],"Since":[469],"serve":[472],"sinks":[474],"noxious":[477],"proteins,":[478],"act":[481],"promote":[483],"viability.":[485],"National":[486],"Library":[487],"Medicine":[489],"Classification:":[490],"WL":[491],"359":[492],"Medical":[493],"Subject":[494],"Headings:":[495],"disease;":[497,511],"apoptosis;":[498],"brain/pathology;":[499],"human;":[500],"immunohistochemistry;":[501],"bodies;":[503,505],"diseases/pathology;":[507],"tangles;":[509],"proteins/abnormalities;":[512],"tauopathies;":[513],"ubiquitin":[514]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
