{"id":"https://openalex.org/W2184302803","doi":null,"title":"A comparative study on the protective effects of 17beta-estradiol, biochanin A and bisphenol A on mammary gland differentiation and tumorigenesis in rats.","display_name":"A comparative study on the protective effects of 17beta-estradiol, biochanin A and bisphenol A on mammary gland differentiation and tumorigenesis in rats.","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W2184302803","mag":"2184302803","pmid":"https://pubmed.ncbi.nlm.nih.gov/16872042"},"language":"en","primary_location":{"id":"pmid:16872042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16872042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hong Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405287266","display_name":"Research Institute for Radiation Biology and Medicine, Hiroshima University","ror":"https://ror.org/04mfv5z87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hong Yin","raw_affiliation_strings":["Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University. Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University. Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020597801","display_name":"Akihiro Ito","orcid":"https://orcid.org/0000-0001-7224-1100","observed_orcids":["https://orcid.org/0000-0001-7224-1100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiro Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103556167","display_name":"Dilip Bhattacharjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dilip Bhattacharjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045771912","display_name":"Masaharu Hoshi","orcid":"https://orcid.org/0000-0001-6978-0883","observed_orcids":["https://orcid.org/0000-0001-6978-0883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaharu Hoshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1317,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.42134063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"44","issue":"7","first_page":"540","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.1679999977350235,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/biochanin-a","display_name":"biochanin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":1.0},{"id":"https://openalex.org/keywords/mammary-gland-differentiation","display_name":"mammary gland differentiation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/n-nitroso-n-methylurea","display_name":"N-nitroso-N-methylurea","score":0.8579999804496765},{"id":"https://openalex.org/keywords/terminal-end-buds","display_name":"terminal end buds","score":0.8370000123977661},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7269999980926514},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.8790000081062317},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.7332112789154053},{"id":"https://openalex.org/C2778821405","wikidata":"https://www.wikidata.org/wiki/Q864222","display_name":"Biochanin A","level":4,"score":0.7275105714797974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.648527204990387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6396865844726562},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.5044840574264526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4105628728866577},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3596946597099304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32476699352264404},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.2545318007469177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16842642426490784},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.10015147924423218},{"id":"https://openalex.org/C2780955279","wikidata":"https://www.wikidata.org/wiki/Q408732","display_name":"Daidzein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000098826","descriptor_name":"Bisphenol A Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008770","descriptor_name":"Methylnitrosourea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16872042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16872042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1898676131","https://openalex.org/W1966251618","https://openalex.org/W1995632155","https://openalex.org/W2009434975","https://openalex.org/W2022373675","https://openalex.org/W2025807806","https://openalex.org/W2026159928","https://openalex.org/W2028857488","https://openalex.org/W2036142628","https://openalex.org/W2042956812","https://openalex.org/W2061975024","https://openalex.org/W2067706117","https://openalex.org/W2073417234","https://openalex.org/W2083788758","https://openalex.org/W2084913075","https://openalex.org/W2087919607","https://openalex.org/W2088236232","https://openalex.org/W2130404690","https://openalex.org/W2148531812","https://openalex.org/W2285863901","https://openalex.org/W2340585393","https://openalex.org/W2387985708","https://openalex.org/W3211640977"],"related_works":["https://openalex.org/W2073971013","https://openalex.org/W2343522962","https://openalex.org/W2017843735","https://openalex.org/W2171196665","https://openalex.org/W1991456147","https://openalex.org/W2260501589","https://openalex.org/W2272473912","https://openalex.org/W2080215858","https://openalex.org/W2053994248","https://openalex.org/W2024936011"],"abstract_inverted_index":{"Mammary":[0],"tissue":[1],"differentiation":[2,122],"and":[3,16,67,95,102,139,144],"tumorigenesis":[4],"were":[5,52,78,146],"studied":[6],"in":[7,135,149],"female":[8],"rats":[9,51,77],"following":[10],"subcutaneous":[11],"injection":[12],"at":[13,90],"2,":[14],"4":[15],"6":[17],"days":[18],"after":[19,129],"birth":[20],"with":[21,81],"low":[22],"or":[23,29,36,40,44],"high":[24,151],"doses":[25],"of":[26,49,71,84,87,93,104,119,142],"17beta-estradiol":[27],"(0.1":[28,35,43],"10":[30,37],"microg;":[31],"E2),":[32],"biochanin":[33],"A":[34,42],"mg;":[38,46],"BCA)":[39],"bisphenol":[41],"10.0":[45],"BPA).":[47],"Half":[48],"the":[50,59,72,117,140],"killed":[53],"on":[54],"day":[55],"35":[56],"to":[57],"analyze":[58],"terminal":[60,64],"end":[61],"bud":[62,69],"(TEB),":[63],"duct":[65],"(TD)":[66],"alveolar":[68],"(AB)":[70],"mammary":[73,105,120],"tissue.":[74],"The":[75,100],"remaining":[76],"injected,":[79],"ip,":[80],"a":[82],"dose":[83,152],"50":[85],"mg/kg":[86],"N-nitroso-N-methylurea":[88],"(MNU)":[89],"7":[91],"weeks":[92,98],"age":[94],"sacrificed":[96],"26":[97],"later.":[99],"incidence":[101],"multiplicity":[103],"tumors":[106],"(MT)":[107],"decreased":[108,133],"among":[109],"all":[110],"three":[111],"different":[112],"treated":[113,137],"groups,":[114],"dose-dependently.":[115],"However,":[116],"pattern":[118],"gland":[121],"varied.":[123],"No":[124],"significant":[125],"difference":[126],"was":[127],"observed":[128],"E2":[130],"administration.":[131],"TEB":[132],"dose-dependently":[134],"BCA":[136],"groups":[138],"number":[141],"TD":[143],"AB":[145],"suppressed":[147],"significantly":[148],"BPA":[150],"group.":[153]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
